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Articles

mu-Opioid receptor activation reduces multiple components of high- threshold calcium current in rat sensory neurons

KI Rusin and HC Moises
Journal of Neuroscience 1 June 1995, 15 (6) 4315-4327; DOI: https://doi.org/10.1523/JNEUROSCI.15-06-04315.1995
KI Rusin
Department of Physiology, University of Michigan, Ann Arbor 48109–0622, USA.
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HC Moises
Department of Physiology, University of Michigan, Ann Arbor 48109–0622, USA.
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Abstract

Whole-cell patch-clamp recordings were used to characterize calcium channel types that are modulated by mu-opioid receptor activation in rat dorsal root ganglion (DRG) neurons. Five distinct components of high-threshold calcium current were isolated on the basis of their sensitivity to the selective channel blockers omega-conotoxin GVIA, nifedipine, omega-conotoxin MVIIC, or omega-agatoxin IVA. The mu-opioid selective agonist Tyr-Pro-NMePhe-D-Pro-NH2 (PLO17) routinely suppressed high-threshold currents and this effect was always reduced by omega- conotoxin GVIA. A fraction of PLO17-sensitive current remained after omega-conotoxin GVIA that was eliminated by application of omega- agatoxin IVA alone or in combination with omega-conotoxin MVIIC. Nifedipine had no effect on mu-opioid responses nor did PLO17 affect the slow component of tail current induced by Bay K 8644. These data suggest that mu-opioid receptors are negatively coupled to three types of calcium channels in rat DRG neurons, including an omega-conotoxin GVIA-sensitive (N-type) channel, an omega-agatoxin IVA-sensitive (P- type) channel and an omega-conotoxin MVIIC-sensitive, nifedipine/GVIA/omega-Aga IVA-resistant (presumptive Q-type) channel.

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The Journal of Neuroscience: 15 (6)
Journal of Neuroscience
Vol. 15, Issue 6
1 Jun 1995
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mu-Opioid receptor activation reduces multiple components of high- threshold calcium current in rat sensory neurons
KI Rusin, HC Moises
Journal of Neuroscience 1 June 1995, 15 (6) 4315-4327; DOI: 10.1523/JNEUROSCI.15-06-04315.1995

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mu-Opioid receptor activation reduces multiple components of high- threshold calcium current in rat sensory neurons
KI Rusin, HC Moises
Journal of Neuroscience 1 June 1995, 15 (6) 4315-4327; DOI: 10.1523/JNEUROSCI.15-06-04315.1995
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