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The Shaker-like potassium channels of the mouse rod bipolar cell and their contributions to the membrane current

DJ Klumpp, EJ Song, S Ito, MH Sheng, LY Jan and LH Pinto
Journal of Neuroscience 1 July 1995, 15 (7) 5004-5013; DOI: https://doi.org/10.1523/JNEUROSCI.15-07-05004.1995
DJ Klumpp
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA.
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EJ Song
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA.
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S Ito
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA.
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MH Sheng
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA.
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LY Jan
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA.
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LH Pinto
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA.
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Abstract

RT PCR on mRNA from enzymatically dissociated, isolated bipolar cells showed that these neurons express the Shaker-like K+ channels Kv1.1, Kv1.2, and Kv1.3. Immunohistochemical localization showed each channel to have a unique subcellular distribution: Kv1.1 immunoreactivity was detected in the dendrites and axons terminal, whereas Kv1.2 and Kv1.3 subunits were localized to the axon and the postsynaptic membrane of the rod ribbon synapse, respectively. Whole-cell patch-clamp recordings indicated that the activation voltage of the delayed rectifier current of the isolated bipolar cell and the inhibitory constants for current blockade by TEA, 4-AP, and Ba2+ were similar to these same properties measured for Kv1.1 expressed in oocytes. However, the TEA and 4-AP inhibitory constants for the bipolar cell current differed from the inhibitory constants for Kv1.2 or Kv1.3. These results suggest that the current of the isolated rod bipolar cell is most similar to Kv1.1 but that all three channels may function in the intact retina to allow complex modulation of retinal synaptic signals.

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The Journal of Neuroscience: 15 (7)
Journal of Neuroscience
Vol. 15, Issue 7
1 Jul 1995
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The Shaker-like potassium channels of the mouse rod bipolar cell and their contributions to the membrane current
DJ Klumpp, EJ Song, S Ito, MH Sheng, LY Jan, LH Pinto
Journal of Neuroscience 1 July 1995, 15 (7) 5004-5013; DOI: 10.1523/JNEUROSCI.15-07-05004.1995

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The Shaker-like potassium channels of the mouse rod bipolar cell and their contributions to the membrane current
DJ Klumpp, EJ Song, S Ito, MH Sheng, LY Jan, LH Pinto
Journal of Neuroscience 1 July 1995, 15 (7) 5004-5013; DOI: 10.1523/JNEUROSCI.15-07-05004.1995
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