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Induction of interleukin-6 in axotomized sensory neurons

PG Murphy, J Grondin, M Altares and PM Richardson
Journal of Neuroscience 1 July 1995, 15 (7) 5130-5138; https://doi.org/10.1523/JNEUROSCI.15-07-05130.1995
PG Murphy
Division of Neurosurgery, McGill University, Montreal, Quebec, Canada.
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J Grondin
Division of Neurosurgery, McGill University, Montreal, Quebec, Canada.
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M Altares
Division of Neurosurgery, McGill University, Montreal, Quebec, Canada.
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PM Richardson
Division of Neurosurgery, McGill University, Montreal, Quebec, Canada.
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Abstract

RNA from rat dorsal root ganglia was analyzed in search of potentially beneficial cytokines that are induced in dorsal root ganglia by nerve injury. By reverse transcription, the PCR, and Southern blotting, interleukin-6 mRNA was detected during development but not in normal adult dorsal root ganglia, reappeared within 1 d of sciatic nerve transection, was maximally increased after 2 and 4 d, and decreased below the threshold of detection within 1 week. By RNase protection assay, interleukin-6 mRNA was consistently present in RNA from dorsal root ganglia removed from rats 4 d following transection but not in control dorsal root ganglia. Interleukin-6 bioactivity was also present in dorsal root ganglia following nerve injury. By in situ hybridization, interleukin-6 mRNA was localized within large and medium- sized axotomized neurons. In summary, some sensory neurons respond to axotomy with a brisk transient increase in synthesis of interleukin-6. Injury to the sciatic nerve also induced mRNAs for interleukin-1 beta and tumor necrosis factor-alpha in dorsal root ganglia. The inductions of interleukin-1 beta and tumor necrosis factor-alpha mRNAs were later and more sustained than that of interleukin-6 mRNA. The cellular sources of these two cytokines have not been defined.

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The Journal of Neuroscience: 15 (7)
Journal of Neuroscience
Vol. 15, Issue 7
1 Jul 1995
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Induction of interleukin-6 in axotomized sensory neurons
PG Murphy, J Grondin, M Altares, PM Richardson
Journal of Neuroscience 1 July 1995, 15 (7) 5130-5138; DOI: 10.1523/JNEUROSCI.15-07-05130.1995

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Induction of interleukin-6 in axotomized sensory neurons
PG Murphy, J Grondin, M Altares, PM Richardson
Journal of Neuroscience 1 July 1995, 15 (7) 5130-5138; DOI: 10.1523/JNEUROSCI.15-07-05130.1995
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