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Repeated confocal imaging of individual dendritic spines in the living hippocampal slice: evidence for changes in length and orientation associated with chemically induced LTP

T Hosokawa, DA Rusakov, TV Bliss and A Fine
Journal of Neuroscience 1 August 1995, 15 (8) 5560-5573; DOI: https://doi.org/10.1523/JNEUROSCI.15-08-05560.1995
T Hosokawa
Department of Physiology and Biophysics, Dalhousie University Faculty of Medicine, Halifax, Nova Scotia, Canada.
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DA Rusakov
Department of Physiology and Biophysics, Dalhousie University Faculty of Medicine, Halifax, Nova Scotia, Canada.
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TV Bliss
Department of Physiology and Biophysics, Dalhousie University Faculty of Medicine, Halifax, Nova Scotia, Canada.
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A Fine
Department of Physiology and Biophysics, Dalhousie University Faculty of Medicine, Halifax, Nova Scotia, Canada.
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Abstract

Using confocal microscopy in conjunction with microdrop application of Dil, we have imaged and measured individual dendritic spines of living hippocampal CA1 pyramidal neurons in acute brain slices, before and approximately 3 hr after induction of long-term potentiation by chemical means. Statistical analysis of changes in the length of individual spines, and comparison with results of Monte Carlo simulations, suggests that two forms of structural change occur in chemically induced long-term potentiation: growth of a subpopulation of small spines, and angular displacement of spines. These changes could provide a structural basis for the expression of long-term potentiation.

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The Journal of Neuroscience: 15 (8)
Journal of Neuroscience
Vol. 15, Issue 8
1 Aug 1995
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Repeated confocal imaging of individual dendritic spines in the living hippocampal slice: evidence for changes in length and orientation associated with chemically induced LTP
T Hosokawa, DA Rusakov, TV Bliss, A Fine
Journal of Neuroscience 1 August 1995, 15 (8) 5560-5573; DOI: 10.1523/JNEUROSCI.15-08-05560.1995

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Repeated confocal imaging of individual dendritic spines in the living hippocampal slice: evidence for changes in length and orientation associated with chemically induced LTP
T Hosokawa, DA Rusakov, TV Bliss, A Fine
Journal of Neuroscience 1 August 1995, 15 (8) 5560-5573; DOI: 10.1523/JNEUROSCI.15-08-05560.1995
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