Article Figures & Data
Figures
- Fig. 1.
Bars represent [3H]WIN 35,428, [3H]GBR 12,935, and [3H]DTBZ binding (expressed as a percentage of control, n = 15) in striatum and nucleus accumbens (nacs) of rats exposed to unlimited-access cocaine self-administration and killed on the last day of cocaine access (n = 10) (hatched bars) or 3 weeks after drug withdrawal (n = 8) (black bars). One-way ANOVA, followed by Fisher’s least significant difference test (asterisk indicates p < 0.05; double asterisk indicates p < 0.001). Data for [3H]WIN 35,428 and [3H]GBR 12,935 bindings are taken from Wilson et al. (1994).
Tables
- Table 1.
[3H]DTBZ binding in rat brain: influence of chronic unlimited access to self-administration of cocaine
Brain region Control On-cocaine Withdrawn Cortex Frontal 12.7 ± 0.2 9.0 ± 0.7 8.1 ± 1.1 Cingulate 12.2 ± 0.7 13.5 ± 1.1 12.5 ± 1.3 Limbic 20.4 ± 0.9 21.7 ± 1.6 18.7 ± 2.0 Occipital 5.2 ± 0.2 5.3 ± 0.8 3.9 ± 0.8 Basal ganglia Nucleus accumbens Whole 240 ± 5 231 ± 10 224 ± 10 Anterior 254 ± 6 234 ± 8 233 ± 12 Posterior 224 ± 3 226 ± 14 218 ± 9 Striatum Whole 202 ± 2 198 ± 9 191 ± 10 Rostral pole 257 ± 10 227 ± 16 229 ± 12 Dorsomedial 266 ± 15 228 ± 26 235 ± 19 Dorsolateral 248 ± 9 213 ± 14 235 ± 14 Ventromedial 273 ± 10 260 ± 11 241 ± 16 Ventrolateral 225 ± 11 206 ± 13 201 ± 12 Rostral body 238 ± 5 233 ± 14 231 ± 10 Dorsomedial 248 ± 9 250 ± 18 249 ± 10 Dorsointermed. 232 ± 6 241 ± 15 227 ± 11 Dorsolateral 229 ± 8 223 ± 11 220 ± 8 Intermed.-medial 265 ± 8 254 ± 16 262 ± 12 Intermed.-intermed. 215 ± 6 210 ± 12 203 ± 11 Intermed.-lateral 209 ± 7 203 ± 10 198 ± 12 Ventromedial 266 ± 7 251 ± 16 258 ± 12 Ventrointermed. 245 ± 6 239 ± 16 236 ± 11 Ventrolateral 238 ± 5 228 ± 15 226 ± 13 Intermediate body 199 ± 4 209 ± 12 194 ± 12 Dorsomedial 202 ± 8 230 ± 16 211 ± 14 Dorsointermed. 188 ± 6 199 ± 15 182 ± 13 Dorsolateral 212 ± 9 212 ± 9 194 ± 15 Intermed.-medial 174 ± 6 186 ± 16 175 ± 14 Intermed.-intermed. 169 ± 3 173 ± 11 158 ± 10 Intermed.-lateral 212 ± 7 212 ± 6 187 ± 10 Ventromedial 169 ± 7 164 ± 11 163 ± 10 Ventrointermed. 218 ± 6 221 ± 10 209 ± 11 Ventrolateral 256 ± 7 257 ± 9 233 ± 15 Caudal body 179 ± 3 174 ± 6 168 ± 10 Dorsal 129 ± 5 132 ± 7 130 ± 10 Intermed. 170 ± 4 162 ± 6 156 ± 11 Ventral 248 ± 7 235 ± 9 227 ± 13 Caudate tail 112 ± 5 109 ± 8 97 ± 7 Bed nucleus of stria terminalis Anterior 89 ± 5 80 ± 6 93 ± 7 Ventral 148 ± 9 145 ± 10 130 ± 11 Fundus striati 221 ± 6 187 ± 24 195 ± 19 Globus pallidus 11.7 ± 0.8 11.8 ± 1.0 9.8 ± 1.6 Basal forebrain Olfactory tubercle Whole 192 ± 5 182 ± 5 185 ± 5 Anterior 192 ± 6 183 ± 4 185 ± 6 Posterior 188 ± 7 181 ± 8 182 ± 4 Lateral septum Dorsal 208 ± 7 256 ± 19 239 ± 9 Intermed. 58 ± 3 78 ± 10 69 ± 6 Ventral 172 ± 6 196 ± 19 191 ± 13 Medial septum 47 ± 5 49 ± 6 45 ± 8 Pyramidal cell layer 22 ± 1 25 ± 2 22 ± 3 Hippocampus 12 ± 1 14 ± 1 12 ± 1 Basolateral amygdala 51 ± 2 54 ± 3 48 ± 3 Diencephalon Suprachiasmatic nucleus 89 ± 14 80 ± 9 57 ± 14 Supraoptic nucleus 145 ± 9 151 ± 10 167 ± 11 Paraventricular nucleus 150 ± 8 183 ± 14 160 ± 13 Hypothalamus Anterior 61 ± 3 76 ± 4 62 ± 4 Dorsomedial 79 ± 7 83 ± 5 79 ± 8 Ventromedial 57 ± 3 56 ± 4 58 ± 3 Lateral preoptic area 51 ± 3 54 ± 6 53 ± 5 Medial preoptic area 80 ± 3 88 ± 3 77 ± 6 Habenula Medial 28 ± 2 31 ± 4 30 ± 3 Lateral 16 ± 5 11 ± 2 15 ± 4 Thalamus Anteroventral thalamic nucleus 55 ± 3 51 ± 3 54 ± 5 Paratenial thalamic nucleus 74 ± 9 72 ± 11 75 ± 7 Paraventricular thalamic nucleus 88 ± 6 87 ± 7 100 ± 12 Midbrain Substantia nigra 92 ± 8 82 ± 5 81 ± 7 Ventral tegmental area 101 ± 5 94 ± 6 91 ± 8 Superior colliculus 27 ± 1 29 ± 2 25 ± 2 Periaqueductal grey 33 ± 2 37 ± 3 34 ± 4 Medial raphe 56 ± 14 43 ± 12 61 ± 13 Dorsal raphe 144 ± 12 148 ± 11 140 ± 21 Subincertal nucleus 55 ± 3 51 ± 4 44 ± 3 Brainstem Locus coeruleus 174 ± 39 267 ± 23 209 ± 47 Data are subregional distribution (mean ± SEM; pmol/μg tissue) of [3H]DTBZ binding in brain of control rats (n = 15) and of rats killed on the last day of (n = 10) or 3 weeks after withdrawal from (n = 8) chronic, unlimited access to self-administration of cocaine.
