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Articles

The Vesicular Monoamine Transporter, in Contrast to the Dopamine Transporter, Is Not Altered by Chronic Cocaine Self-Administration in the Rat

Julie M. Wilson and Stephen J. Kish
Journal of Neuroscience 15 May 1996, 16 (10) 3507-3510; https://doi.org/10.1523/JNEUROSCI.16-10-03507.1996
Julie M. Wilson
1Human Neurochemical Pathology Laboratory, Clarke Institute of Psychiatry, Toronto, Ontario, Canada M5T 1R8
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Stephen J. Kish
1Human Neurochemical Pathology Laboratory, Clarke Institute of Psychiatry, Toronto, Ontario, Canada M5T 1R8
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    Fig. 1.

    Bars represent [3H]WIN 35,428, [3H]GBR 12,935, and [3H]DTBZ binding (expressed as a percentage of control, n = 15) in striatum and nucleus accumbens (nacs) of rats exposed to unlimited-access cocaine self-administration and killed on the last day of cocaine access (n = 10) (hatched bars) or 3 weeks after drug withdrawal (n = 8) (black bars). One-way ANOVA, followed by Fisher’s least significant difference test (asterisk indicates p < 0.05; double asterisk indicates p < 0.001). Data for [3H]WIN 35,428 and [3H]GBR 12,935 bindings are taken from Wilson et al. (1994).

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    Table 1.

    [3H]DTBZ binding in rat brain: influence of chronic unlimited access to self-administration of cocaine

    Brain regionControlOn-cocaineWithdrawn
    Cortex
    Frontal12.7  ± 0.29.0  ± 0.78.1  ± 1.1
    Cingulate12.2  ± 0.713.5  ± 1.112.5  ± 1.3
    Limbic20.4  ± 0.921.7  ± 1.618.7  ± 2.0
    Occipital5.2  ± 0.25.3  ± 0.83.9  ± 0.8
    Basal ganglia
    Nucleus accumbens
    Whole240  ± 5231  ± 10224  ± 10
    Anterior254  ± 6234  ± 8233  ± 12
    Posterior224  ± 3226  ± 14218  ± 9
    Striatum
    Whole202  ± 2198  ± 9191  ± 10
    Rostral pole257  ± 10227  ± 16229  ± 12
    Dorsomedial266  ± 15228  ± 26235  ± 19
    Dorsolateral248  ± 9213  ± 14235  ± 14
    Ventromedial273  ± 10260  ± 11241  ± 16
    Ventrolateral225  ± 11206  ± 13201  ± 12
    Rostral body238  ± 5233  ± 14231  ± 10
    Dorsomedial248  ± 9250  ± 18249  ± 10
    Dorsointermed.232  ± 6241  ± 15227  ± 11
    Dorsolateral229  ± 8223  ± 11220  ± 8
    Intermed.-medial265  ± 8254  ± 16262  ± 12
    Intermed.-intermed.215  ± 6210  ± 12203  ± 11
    Intermed.-lateral209  ± 7203  ± 10198  ± 12
    Ventromedial266  ± 7251  ± 16258  ± 12
    Ventrointermed.245  ± 6239  ± 16236  ± 11
    Ventrolateral238  ± 5228  ± 15226  ± 13
    Intermediate body199  ± 4209  ± 12194  ± 12
    Dorsomedial202  ± 8230  ± 16211  ± 14
    Dorsointermed.188  ± 6199  ± 15182  ± 13
    Dorsolateral212  ± 9212  ± 9194  ± 15
    Intermed.-medial174  ± 6186  ± 16175  ± 14
    Intermed.-intermed.169  ± 3173  ± 11158  ± 10
    Intermed.-lateral212  ± 7212  ± 6187  ± 10
    Ventromedial169  ± 7164  ± 11163  ± 10
    Ventrointermed.218  ± 6221  ± 10209  ± 11
    Ventrolateral256  ± 7257  ± 9233  ± 15
    Caudal body179  ± 3174  ± 6168  ± 10
    Dorsal129  ± 5132  ± 7130  ± 10
    Intermed.170  ± 4162  ± 6156  ± 11
    Ventral248  ± 7235  ± 9227  ± 13
    Caudate tail112  ± 5109  ± 897  ± 7
    Bed nucleus of stria terminalis
    Anterior89  ± 580  ± 693  ± 7
    Ventral148  ± 9145  ± 10130  ± 11
    Fundus striati221  ± 6187  ± 24195  ± 19
    Globus pallidus11.7  ± 0.811.8  ± 1.09.8  ± 1.6
    Basal forebrain
    Olfactory tubercle
    Whole192  ± 5182  ± 5185  ± 5
    Anterior192  ± 6183  ± 4185  ± 6
    Posterior188  ± 7181  ± 8182  ± 4
    Lateral septum
    Dorsal208  ± 7256  ± 19239  ± 9
    Intermed.58  ± 378  ± 1069  ± 6
    Ventral172  ± 6196  ± 19191  ± 13
    Medial septum47  ± 549  ± 645  ± 8
    Pyramidal cell layer22  ± 125  ± 222  ± 3
    Hippocampus12  ± 114  ± 112  ± 1
    Basolateral amygdala51  ± 254  ± 348  ± 3
    Diencephalon
    Suprachiasmatic nucleus89  ± 1480  ± 957  ± 14
    Supraoptic nucleus145  ± 9151  ± 10167  ± 11
    Paraventricular nucleus150  ± 8183  ± 14160  ± 13
    Hypothalamus
    Anterior61  ± 376  ± 462  ± 4
    Dorsomedial79  ± 783  ± 579  ± 8
    Ventromedial57  ± 356  ± 458  ± 3
    Lateral preoptic area51  ± 354  ± 653  ± 5
    Medial preoptic area80  ± 388  ± 377  ± 6
    Habenula
    Medial28  ± 231  ± 430  ± 3
    Lateral16  ± 511  ± 215  ± 4
    Thalamus
    Anteroventral thalamic nucleus55  ± 351  ± 354  ± 5
    Paratenial thalamic nucleus74  ± 972  ± 1175  ± 7
    Paraventricular thalamic nucleus88  ± 687  ± 7100  ± 12
    Midbrain
    Substantia nigra92  ± 882  ± 581  ± 7
    Ventral tegmental area101  ± 594  ± 691  ± 8
    Superior colliculus27  ± 129  ± 225  ± 2
    Periaqueductal grey33  ± 237  ± 334  ± 4
    Medial raphe56  ± 1443  ± 1261  ± 13
    Dorsal raphe144  ± 12148  ± 11140  ± 21
    Subincertal nucleus55  ± 351  ± 444  ± 3
    Brainstem
    Locus coeruleus174  ± 39267  ± 23209  ± 47
    • Data are subregional distribution (mean ± SEM; pmol/μg tissue) of [3H]DTBZ binding in brain of control rats (n = 15) and of rats killed on the last day of (n = 10) or 3 weeks after withdrawal from (n = 8) chronic, unlimited access to self-administration of cocaine.

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The Journal of Neuroscience: 16 (10)
Journal of Neuroscience
Vol. 16, Issue 10
15 May 1996
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The Vesicular Monoamine Transporter, in Contrast to the Dopamine Transporter, Is Not Altered by Chronic Cocaine Self-Administration in the Rat
Julie M. Wilson, Stephen J. Kish
Journal of Neuroscience 15 May 1996, 16 (10) 3507-3510; DOI: 10.1523/JNEUROSCI.16-10-03507.1996

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The Vesicular Monoamine Transporter, in Contrast to the Dopamine Transporter, Is Not Altered by Chronic Cocaine Self-Administration in the Rat
Julie M. Wilson, Stephen J. Kish
Journal of Neuroscience 15 May 1996, 16 (10) 3507-3510; DOI: 10.1523/JNEUROSCI.16-10-03507.1996
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Keywords

  • cocaine
  • vesicular monoamine transporter
  • dihydrotetrabenazine
  • quantitative autoradiography
  • self-administration
  • unlimited access

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