Article Figures & Data
Figures
- Fig. 1.
Effects of ADX (hatched bars), GDX (open bars), and ADX+GDX (solid bars) on hybridization signals (μCi/gm tissue) for mRNAs encoding MR and GR in the hippocampus and CRH in the PVN of male (left panels) and female (right panels) rats. Shaded areas represent data (±SEM range) obtained in sham-operated controls. All values shown represent mean ± SEM (n = 5 per group). Asterisks denote significant differences from levels measured in sham-operated controls.
- Fig. 2.
Changes in hybridization signals for MR, GR, and CRH mRNAs in ADX+GDX male (left panels) and female (right panels) rats, as induced by administration of E2 (open bars), P (hatched bars), E2+P (cross-hatched bars), and DHT (solid bars). Hybridization signals (μCi/gm tissue) measured in vehicle-treated ADX+GDX rats are indicated byshaded areas. Asterisks denote significant effects as compared to vehicle-treated ADX+GDX animals. Data represent mean ± SEM of determinations in five individuals.
- Fig. 3.
Effects of E2 (open bars), P (hatched bars), E2+P (cross-hatched bars), and DHT (solid bars) on MR, GR, and CRH mRNA levels in ADX+GDX male (left panels) and female (right panels) rats that were simultaneously exposed to supraphysiological doses of B. Shaded areas depict hybridization signals (±SEM range) measured in B-implanted ADX+GDX animals receiving oil injections instead of gonadal steroids. Asterisks indicate significant differences between vehicle- and sex steroid-treated rats; data represent mean ± SEM of five individuals.
Tables
- Table 1.
Relative magnitude of ADX-, GDX-, and B-induced changes in mRNAs encoding hippocampal corticosteroid receptors and CRH in the PVN
Treatment Gender MR mRNA GR mRNA CRH mRNA ADX Males 130.8 ± 4.37 126.4 ± 6.31 133.8 ± 1.07 Females 126.5 ± 0.64 123.6 ± 3.63 156.8 ± 4.07* GDX Males 95.8 ± 3.47 93.4 ± 4.19 101.4 ± 1.83 Females 100.0 ± 2.12 78.0 ± 2.42* 115.0 ± 5.93 ADX+GDX Males 118.0 ± 2.05 119.6 ± 2.20 130.8 ± 1.56 Females 130.8 ± 2.52* 123.6 ± 3.97 151.0 ± 5.03* ADX+GDX+B Males 90.5 ± 3.62 68.8 ± 2.44 52.6 ± 2.36 Females 94.2 ± 2.42 74.2 ± 2.35 81.2 ± 4.41* Data are given in percent (mean ± SEM from 5 individuals) of the group average determined in sham-operated controls. Asterisks indicate significant gender differences (p ≤ 0.05).
