Fig. 6. NPY Y1- and Y2-like receptors mediate the inhibition of whole-cell barium currents in the same SCN neuron.A, Inhibition by Y2 agonist NPY 13-36 (80 nm). A1, Barium currents (IBa) evoked by test potential from −80 mV to 0 mV before, during, and after the application of NPY 13-36.A2, I–V curve of theIBa before and during NPY 13-36 application.B, Inhibition of IBa by Y1 agonist [Leu31, Pro34]-NPY (80 nm) in the same neuron. B1,IBa before, during, and after the application of [Leu31, Pro34]-NPY. B2, I–Vcurve IBa before and during [Leu31, Pro34]-NPY application. Notice that NPY 13-36 produced greater inhibition than [Leu31, Pro34]-NPY in this neuron. Neither NPY 13-36 nor [Leu31, Pro34]-NPY changed the I–V relationship of the barium currents.