Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation

HG Kuhn; H Dickinson-Anson; FH Gage

doi:10.1523/JNEUROSCI.16-06-02027.1996

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.16-06-02027.1996

PubMed

8604047

Published By

Society for Neuroscience

History

First published March 15, 1996.

Version of record published March 15, 1996.

Author Information

HG Kuhn,
H Dickinson-Anson, and
FH Gage

Laboratory of Genetics, Salk Institute, La Jolla, California 92037, USA.

Author contributions

Disclosures

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	Abstract	Full	Pdf
Jan 1999	3	0	0
Feb 1999	11	0	0
Mar 1999	13	0	0
Dec 1999	9	0	0
Total 1999	36	0	0
Jan 2000	26	0	0
Feb 2000	26	0	0
Mar 2000	23	0	0
Apr 2000	27	0	0
May 2000	19	0	0
Jun 2000	9	0	0
Jul 2000	14	0	0
Aug 2000	10	0	0
Sep 2000	14	0	0
Oct 2000	15	0	0
Nov 2000	8	0	0
Dec 2000	24	0	0
Total 2000	215	0	0
Jan 2001	29	0	0
Feb 2001	15	0	0
Mar 2001	32	0	0
Apr 2001	30	0	0
May 2001	30	0	0
Jun 2001	19	0	0
Jul 2001	27	1	0
Aug 2001	19	0	0
Sep 2001	36	0	0
Oct 2001	36	0	0
Nov 2001	25	0	0
Dec 2001	26	0	0
Total 2001	324	1	0
Jan 2002	40	0	0
Feb 2002	27	0	0
Mar 2002	54	0	0
Apr 2002	58	0	0
May 2002	42	0	1
Jun 2002	42	0	0
Jul 2002	37	0	0
Aug 2002	30	0	0
Sep 2002	44	0	0
Oct 2002	29	0	0
Nov 2002	46	1	0
Dec 2002	34	0	0
Total 2002	483	1	1
Jan 2003	41	0	0
Feb 2003	30	0	0
Mar 2003	33	0	0
Apr 2003	41	6	3
May 2003	44	0	0
Jun 2003	40	0	0
Jul 2003	29	0	0
Aug 2003	26	0	0
Sep 2003	38	0	0
Oct 2003	47	0	0
Nov 2003	38	0	22
Dec 2003	22	0	49
Total 2003	429	6	74
Jan 2004	41	0	63
Feb 2004	24	2	67
Mar 2004	32	0	91
Apr 2004	37	0	53
May 2004	39	3	147
Jun 2004	16	0	139
Jul 2004	23	0	102
Aug 2004	23	0	91
Sep 2004	26	3	131
Oct 2004	24	2	117
Nov 2004	36	0	85
Dec 2004	41	0	60
Total 2004	362	10	1146
Jan 2005	42	0	139
Feb 2005	33	1	110
Mar 2005	39	0	178
Apr 2005	27	1	157
May 2005	29	0	117
Jun 2005	33	0	126
Jul 2005	26	0	121
Aug 2005	33	0	78
Sep 2005	31	0	160
Oct 2005	86	0	193
Nov 2005	65	2	160
Dec 2005	49	1	141
Total 2005	493	5	1680
Jan 2006	47	0	146
Feb 2006	68	0	121
Mar 2006	54	0	128
Apr 2006	42	0	107
May 2006	42	0	117
Jun 2006	37	0	116
Jul 2006	16	0	114
Aug 2006	31	0	87
Sep 2006	31	0	113
Oct 2006	36	0	124
Nov 2006	38	0	145
Dec 2006	28	0	81
Total 2006	470	0	1399
Jan 2007	35	0	124
Feb 2007	44	0	127
Mar 2007	57	0	138
Apr 2007	75	0	237
May 2007	68	0	140
Jun 2007	48	0	140
Jul 2007	41	0	105
Aug 2007	33	0	104
Sep 2007	33	0	118
Oct 2007	39	0	118
Nov 2007	42	0	132
Dec 2007	51	0	110
Total 2007	566	0	1593
Jan 2008	67	0	162
Feb 2008	38	0	136
Mar 2008	57	0	153
Apr 2008	87	0	143
May 2008	46	0	130
Jun 2008	57	0	141
Jul 2008	50	0	105
Aug 2008	42	0	100
Sep 2008	34	0	130
Oct 2008	52	0	142
Nov 2008	62	0	125
Dec 2008	51	0	103
Total 2008	643	0	1570
Jan 2009	37	0	101
Feb 2009	59	0	135
Mar 2009	90	0	158
Apr 2009	90	0	154
May 2009	61	0	113
Jun 2009	61	0	137
Jul 2009	80	0	129
Aug 2009	87	0	114
Sep 2009	69	0	115
Oct 2009	111	0	130
Nov 2009	90	0	198
Dec 2009	74	0	127
Total 2009	909	0	1611
Jan 2010	55	0	142
Feb 2010	73	0	156
Mar 2010	69	0	147
Apr 2010	69	0	169
May 2010	51	0	177
Jun 2010	59	0	181
Jul 2010	56	0	173
Aug 2010	41	0	160
Sep 2010	47	0	177
Oct 2010	33	0	168
Nov 2010	91	0	220
Dec 2010	57	0	169
Total 2010	701	0	2039
Jan 2011	59	0	2836
Feb 2011	356	0	252
Mar 2011	565	0	248
Apr 2011	162	0	275
May 2011	121	2	213
Jun 2011	88	4	163
Jul 2011	76	1	149
Aug 2011	78	9	179
Sep 2011	96	0	149
Oct 2011	110	4	209
Nov 2011	111	3	213
Dec 2011	91	0	169
Total 2011	1913	23	5055
Jan 2012	122	1	209
Feb 2012	116	0	248
Mar 2012	131	1	235
Apr 2012	134	2	219
May 2012	117	0	218
Jun 2012	98	0	183
Jul 2012	83	1	183
Aug 2012	94	0	187
Sep 2012	103	1	201
Oct 2012	119	0	248
Nov 2012	138	0	308
Dec 2012	145	0	309
Total 2012	1400	6	2748
Jan 2013	165	1	335
Feb 2013	109	0	218
Mar 2013	147	3	342
Apr 2013	157	1	308
May 2013	129	0	279
Jun 2013	136	0	219
Jul 2013	85	0	243
Aug 2013	95	0	250
Sep 2013	92	0	215
Oct 2013	146	1	257
Nov 2013	102	2	301
Dec 2013	94	1	216
Total 2013	1457	9	3183
Jan 2014	74	1	303
Feb 2014	82	4	394
Mar 2014	255	0	367
Apr 2014	213	0	421
May 2014	180	0	387
Jun 2014	949	0	271
Jul 2014	243	0	262
Aug 2014	217	0	255
Sep 2014	124	0	256
Oct 2014	194	3	184
Nov 2014	163	1	193
Dec 2014	152	1	134
Total 2014	2846	10	3427
Jan 2015	143	1	118
Feb 2015	141	4	147
Mar 2015	163	0	193
Apr 2015	116	0	169
May 2015	205	0	244
Jun 2015	114	0	173
Jul 2015	320	1	198
Aug 2015	100	0	178
Sep 2015	165	0	236
Oct 2015	316	8	334
Nov 2015	276	0	275
Dec 2015	160	0	224
Total 2015	2219	14	2489
Jan 2016	573	1	247
Feb 2016	341	0	275
Mar 2016	382	8	509
Apr 2016	247	0	139
May 2016	244	1	169
Jun 2016	260	1	135
Jul 2016	268	2	114
Aug 2016	261	1	165
Sep 2016	252	2	149
Oct 2016	320	2	207
Nov 2016	331	0	133
Dec 2016	365	0	106
Total 2016	3844	18	2348
Jan 2017	362	0	85
Feb 2017	460	0	108
Mar 2017	473	0	133
Apr 2017	399	0	163
May 2017	393	0	184
Jun 2017	275	0	123
Jul 2017	250	0	126
Aug 2017	244	0	81
Sep 2017	273	0	103
Oct 2017	339	0	142
Nov 2017	357	0	115
Dec 2017	295	0	138
Total 2017	4120	0	1501
Jan 2018	217	0	127
Feb 2018	247	0	158
Mar 2018	219	0	131
Apr 2018	263	0	176
May 2018	205	0	84
Jun 2018	167	0	93
Jul 2018	151	0	69
Aug 2018	174	0	80
Sep 2018	159	0	67
Oct 2018	213	0	132
Nov 2018	199	0	107
Dec 2018	196	0	126
Total 2018	2410	0	1350
Jan 2019	181	0	95
Feb 2019	142	0	87
Mar 2019	200	0	115
Apr 2019	223	0	110
May 2019	197	0	99
Jun 2019	118	0	78
Jul 2019	127	0	98
Aug 2019	181	0	108
Sep 2019	147	0	87
Oct 2019	229	0	86
Nov 2019	169	0	84
Dec 2019	90	0	42
Total 2019	2004	0	1089
Jan 2020	122	0	37
Feb 2020	103	0	50
Mar 2020	110	0	53
Apr 2020	127	0	73
May 2020	113	0	88
Jun 2020	127	0	65
Jul 2020	118	0	74
Aug 2020	86	0	69
Sep 2020	181	0	140
Oct 2020	210	0	142
Nov 2020	162	0	167
Dec 2020	190	0	130
Total 2020	1649	0	1088
Jan 2021	197	0	106
Feb 2021	159	0	123
Mar 2021	197	0	161
Apr 2021	175	0	151
May 2021	160	0	95
Jun 2021	171	0	109
Jul 2021	109	0	74
Aug 2021	152	0	66
Sep 2021	98	0	37
Total 2021	1418	0	922
Total	30911	103	36313