Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus

M Nibuya; EJ Nestler; RS Duman

doi:10.1523/JNEUROSCI.16-07-02365.1996

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.16-07-02365.1996

PubMed

8601816

Published By

Society for Neuroscience

History

First published April 1, 1996.

Version of record published April 1, 1996.

Author Information

M Nibuya,
EJ Nestler, and
RS Duman

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA.

Author contributions

Disclosures

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	Abstract	Full	Pdf
Jan 1999	4	0	0
Feb 1999	3	0	0
Mar 1999	4	0	0
Dec 1999	9	0	0
Total 1999	20	0	0
Jan 2000	9	0	0
Feb 2000	7	0	0
Mar 2000	14	0	0
Apr 2000	14	0	0
May 2000	13	0	0
Jun 2000	13	0	0
Jul 2000	10	0	0
Aug 2000	7	0	0
Sep 2000	14	0	0
Oct 2000	8	0	0
Nov 2000	11	0	0
Dec 2000	3	0	0
Total 2000	123	0	0
Jan 2001	11	0	0
Feb 2001	18	0	0
Mar 2001	15	0	1
Apr 2001	11	0	2
May 2001	15	0	1
Jun 2001	16	0	0
Jul 2001	16	0	0
Aug 2001	7	0	0
Sep 2001	7	0	0
Oct 2001	9	0	0
Nov 2001	19	0	0
Dec 2001	9	0	0
Total 2001	153	0	4
Jan 2002	6	0	0
Feb 2002	12	0	0
Mar 2002	21	0	0
Apr 2002	6	0	0
May 2002	14	0	1
Jun 2002	14	0	0
Jul 2002	13	3	0
Aug 2002	4	0	0
Sep 2002	17	0	0
Oct 2002	16	1	0
Nov 2002	16	0	0
Dec 2002	15	0	0
Total 2002	154	4	1
Jan 2003	19	5	0
Feb 2003	16	0	0
Mar 2003	29	0	0
Apr 2003	19	0	0
May 2003	19	0	0
Jun 2003	18	0	0
Jul 2003	28	0	0
Aug 2003	17	0	0
Sep 2003	23	0	0
Oct 2003	37	2	0
Nov 2003	27	1	29
Dec 2003	18	0	19
Total 2003	270	8	48
Jan 2004	12	0	28
Feb 2004	19	0	27
Mar 2004	36	0	84
Apr 2004	37	1	19
May 2004	26	0	45
Jun 2004	15	0	27
Jul 2004	11	0	40
Aug 2004	30	0	32
Sep 2004	32	0	50
Oct 2004	16	0	43
Nov 2004	13	2	46
Dec 2004	32	0	47
Total 2004	279	3	488
Jan 2005	30	2	47
Feb 2005	25	0	67
Mar 2005	23	0	73
Apr 2005	12	1	57
May 2005	15	0	61
Jun 2005	8	1	65
Jul 2005	14	0	48
Aug 2005	6	0	55
Sep 2005	5	0	55
Oct 2005	15	0	72
Nov 2005	20	0	60
Dec 2005	6	0	63
Total 2005	179	4	723
Jan 2006	3	0	47
Feb 2006	25	0	75
Mar 2006	16	0	59
Apr 2006	10	1	52
May 2006	14	0	52
Jun 2006	9	0	41
Jul 2006	11	0	53
Aug 2006	19	0	27
Sep 2006	18	0	48
Oct 2006	17	0	74
Nov 2006	14	0	47
Dec 2006	10	0	34
Total 2006	166	1	609
Jan 2007	11	0	293
Feb 2007	17	0	45
Mar 2007	9	0	43
Apr 2007	36	0	67
May 2007	20	0	89
Jun 2007	19	0	53
Jul 2007	20	0	70
Aug 2007	10	0	36
Sep 2007	16	0	51
Oct 2007	20	0	92
Nov 2007	14	0	71
Dec 2007	2	0	33
Total 2007	194	0	943
Jan 2008	6	0	61
Feb 2008	12	0	47
Mar 2008	13	0	48
Apr 2008	10	0	52
May 2008	17	0	94
Jun 2008	6	0	46
Jul 2008	6	0	34
Aug 2008	13	0	40
Sep 2008	17	0	36
Oct 2008	38	0	22
Nov 2008	19	0	43
Dec 2008	16	0	26
Total 2008	173	0	549
Jan 2009	14	0	27
Feb 2009	12	0	19
Mar 2009	28	0	67
Apr 2009	38	0	50
May 2009	35	0	46
Jun 2009	19	0	34
Jul 2009	19	0	28
Aug 2009	37	0	35
Sep 2009	25	0	28
Oct 2009	21	0	57
Nov 2009	23	0	68
Dec 2009	27	0	47
Total 2009	298	0	506
Jan 2010	24	0	54
Feb 2010	26	0	56
Mar 2010	26	0	44
Apr 2010	36	0	43
May 2010	27	0	41
Jun 2010	25	0	36
Jul 2010	26	0	37
Aug 2010	22	0	54
Sep 2010	25	0	45
Oct 2010	17	0	42
Nov 2010	29	0	47
Dec 2010	37	0	39
Total 2010	320	0	538
Jan 2011	34	0	48
Feb 2011	31	0	84
Mar 2011	44	0	91
Apr 2011	20	0	90
May 2011	24	1	37
Jun 2011	39	0	46
Jul 2011	27	0	28
Aug 2011	35	1	40
Sep 2011	42	0	52
Oct 2011	36	1	67
Nov 2011	33	1	79
Dec 2011	46	3	108
Total 2011	411	7	770
Jan 2012	31	0	60
Feb 2012	38	0	72
Mar 2012	29	1	47
Apr 2012	44	0	54
May 2012	38	0	87
Jun 2012	24	0	46
Jul 2012	33	0	62
Aug 2012	20	0	62
Sep 2012	35	0	55
Oct 2012	34	0	66
Nov 2012	48	1	84
Dec 2012	72	0	63
Total 2012	446	2	758
Jan 2013	67	0	65
Feb 2013	67	0	52
Mar 2013	45	0	43
Apr 2013	70	0	89
May 2013	41	0	66
Jun 2013	40	0	66
Jul 2013	36	0	58
Aug 2013	38	0	45
Sep 2013	41	0	56
Oct 2013	57	1	45
Nov 2013	53	0	57
Dec 2013	46	0	87
Total 2013	601	1	729
Jan 2014	54	0	43
Feb 2014	31	0	47
Mar 2014	60	0	53
Apr 2014	51	0	81
May 2014	34	1	73
Jun 2014	33	0	37
Jul 2014	26	0	41
Aug 2014	20	0	35
Sep 2014	32	0	34
Oct 2014	42	0	57
Nov 2014	58	0	45
Dec 2014	28	0	76
Total 2014	469	1	622
Jan 2015	86	0	55
Feb 2015	27	0	57
Mar 2015	37	0	64
Apr 2015	34	0	43
May 2015	31	0	52
Jun 2015	204	3	60
Jul 2015	47	0	55
Aug 2015	25	0	36
Sep 2015	456	1	80
Oct 2015	35	0	28
Nov 2015	32	0	47
Dec 2015	38	0	40
Total 2015	1052	4	617
Jan 2016	62	0	46
Feb 2016	49	0	51
Mar 2016	56	1	55
Apr 2016	42	1	36
May 2016	48	1	44
Jun 2016	44	0	42
Jul 2016	43	1	38
Aug 2016	29	4	34
Sep 2016	35	2	25
Oct 2016	51	0	33
Nov 2016	32	0	75
Dec 2016	31	0	45
Total 2016	522	10	524
Jan 2017	38	0	22
Feb 2017	23	0	23
Mar 2017	56	0	18
Apr 2017	32	0	13
May 2017	85	0	22
Jun 2017	35	0	23
Jul 2017	25	0	28
Aug 2017	20	0	18
Sep 2017	30	0	14
Oct 2017	46	0	56
Nov 2017	51	0	57
Dec 2017	30	0	20
Total 2017	471	0	314
Jan 2018	30	0	23
Feb 2018	30	0	53
Mar 2018	45	0	30
Apr 2018	37	0	16
May 2018	43	0	27
Jun 2018	44	0	20
Jul 2018	41	0	31
Aug 2018	29	0	17
Sep 2018	33	0	16
Oct 2018	29	0	17
Nov 2018	40	0	21
Dec 2018	36	0	22
Total 2018	437	0	293
Jan 2019	31	0	14
Feb 2019	51	0	23
Mar 2019	40	0	21
Apr 2019	51	0	23
May 2019	50	0	31
Jun 2019	35	0	27
Jul 2019	19	0	20
Aug 2019	25	0	16
Sep 2019	31	0	19
Oct 2019	46	0	24
Nov 2019	16	0	16
Dec 2019	33	0	16
Total 2019	428	0	250
Jan 2020	22	0	8
Feb 2020	27	0	8
Mar 2020	30	0	16
Apr 2020	23	0	23
May 2020	29	0	26
Jun 2020	11	0	13
Jul 2020	19	0	12
Aug 2020	7	0	10
Sep 2020	46	0	48
Oct 2020	23	0	16
Nov 2020	29	0	24
Dec 2020	35	0	21
Total 2020	301	0	225
Jan 2021	62	0	17
Feb 2021	49	0	19
Mar 2021	41	0	37
Apr 2021	32	0	25
May 2021	54	0	38
Jun 2021	75	0	23
Jul 2021	24	0	14
Aug 2021	40	0	13
Sep 2021	44	0	23
Oct 2021	44	0	31
Nov 2021	48	0	36
Dec 2021	35	0	25
Total 2021	548	0	301
Jan 2022	54	0	17
Feb 2022	22	0	15
Mar 2022	38	0	18
Apr 2022	27	0	15
May 2022	21	0	16
Total 2022	162	0	81
Total	8177	45	9893