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Chronic hyponatremia reduces survival of magnocellular vasopressin and oxytocin neurons after axonal injury

J Dohanics, GE Hoffman and JG Verbalis
Journal of Neuroscience 1 April 1996, 16 (7) 2373-2380; DOI: https://doi.org/10.1523/JNEUROSCI.16-07-02373.1996
J Dohanics
Department of Medicine, University of Pittsburgh, Pennsylvania 15261, USA.
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GE Hoffman
Department of Medicine, University of Pittsburgh, Pennsylvania 15261, USA.
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JG Verbalis
Department of Medicine, University of Pittsburgh, Pennsylvania 15261, USA.
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Abstract

Axonal injury to hypothalamic magnocellular vasopressin (AVP) and oxytocin (OT) neurons causes degeneration of a substantial subpopulation of these neurons. In this study, we investigated the influence of osmolality on this injury-induced cell death. Normonatremic, chronically hypernatremic, and chronically hyponatremic rats received pituitary stalk compression (SC), which causes degeneration of AVP and OT terminals in the neurohypophysis. Twenty-one days after SC, rats were perfused and hypothalami were serially sectioned and alternately stained for AVP-neurophysin and OT- neurophysin immunoreactivities. Normonatremic and hypernatremic rats exhibited a triphasic pattern of water intake after SC, with peak intakes 3 times higher than those exhibited by sham-operated normonatremic rats. In contrast, hyponatremic SC rats exhibited peak water intakes of 600 ml/24 hr, approximately 9–10 times the water intakes of sham-operated normonatremic rats. In normonatremic rats, SC caused degeneration of 65% of the AVP neuron population in the SON and 73% in the PVN, but only 31% of the OT neuron population in the SON and 35% in the PVN. Similar results were found in hypernatremic rats after SC. However, in hyponatremic rats SC caused degeneration of 97% of the AVP neuron population in the SON and 93% in the PVN, and 90% of the OT neuron population in the SON and 84% in the PVN. Our results, therefore, demonstrate that injury-induced degeneration of magnocellular AVP and OT neurons is markedly exacerbated by chronic hypo-osmolar conditions, but neuronal survival is not enhanced by chronic hyperosmolar conditions.

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The Journal of Neuroscience: 16 (7)
Journal of Neuroscience
Vol. 16, Issue 7
1 Apr 1996
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Chronic hyponatremia reduces survival of magnocellular vasopressin and oxytocin neurons after axonal injury
J Dohanics, GE Hoffman, JG Verbalis
Journal of Neuroscience 1 April 1996, 16 (7) 2373-2380; DOI: 10.1523/JNEUROSCI.16-07-02373.1996

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Chronic hyponatremia reduces survival of magnocellular vasopressin and oxytocin neurons after axonal injury
J Dohanics, GE Hoffman, JG Verbalis
Journal of Neuroscience 1 April 1996, 16 (7) 2373-2380; DOI: 10.1523/JNEUROSCI.16-07-02373.1996
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