Resurgent Sodium Current and Action Potential Formation in Dissociated Cerebellar Purkinje Neurons

Indira M. Raman; Bruce P. Bean

doi:10.1523/JNEUROSCI.17-12-04517.1997

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.17-12-04517.1997

PubMed

9169512

Published By

Society for Neuroscience

History

Received January 30, 1997
Revision received March 22, 1997
Accepted March 27, 1997
First published June 15, 1997.

Version of record published June 15, 1997.

Author Information

Indira M. Raman and
Bruce P. Bean

¹Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115

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Author contributions

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Disclosures

Received January 30, 1997.
Revision received March 22, 1997.
Accepted March 27, 1997.

This work was supported by National Institutes of Health Grant HL35034. We are grateful to Dr. N. V. Marrion for advice on single-channel recording and Drs. J. T. Williams and D. Bergles for guidance on current-clamp recording.
Correspondence should be addressed to Dr. Indira M. Raman, Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115.

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	Abstract	Full	Pdf
Jan 1999	2	2	2
Feb 1999	4	17	14
Mar 1999	3	10	18
Dec 1999	0	15	15
Total 1999	9	44	49
Jan 2000	3	13	15
Feb 2000	2	10	7
Mar 2000	7	13	10
Apr 2000	5	14	10
May 2000	3	7	5
Jun 2000	0	12	13
Jul 2000	1	14	18
Aug 2000	0	17	10
Sep 2000	5	13	28
Oct 2000	2	11	12
Nov 2000	1	4	5
Dec 2000	4	17	15
Total 2000	33	145	148
Jan 2001	5	14	15
Feb 2001	4	29	19
Mar 2001	3	13	11
Apr 2001	2	4	4
May 2001	3	15	8
Jun 2001	5	10	11
Jul 2001	1	15	12
Aug 2001	2	5	4
Sep 2001	1	6	4
Oct 2001	3	16	19
Nov 2001	6	18	11
Dec 2001	2	17	12
Total 2001	37	162	130
Jan 2002	7	24	19
Feb 2002	2	17	13
Mar 2002	0	16	12
Apr 2002	5	24	26
May 2002	1	15	23
Jun 2002	0	15	12
Jul 2002	0	16	18
Aug 2002	1	12	18
Sep 2002	3	25	13
Oct 2002	4	21	16
Nov 2002	1	25	25
Dec 2002	0	3	9
Total 2002	24	213	204
Jan 2003	10	23	21
Feb 2003	1	14	12
Mar 2003	1	13	13
Apr 2003	2	22	15
May 2003	4	21	9
Jun 2003	2	18	10
Jul 2003	5	22	14
Aug 2003	12	21	14
Sep 2003	12	35	48
Oct 2003	12	28	33
Nov 2003	17	26	27
Dec 2003	11	41	29
Total 2003	89	284	245
Jan 2004	17	31	23
Feb 2004	13	132	30
Mar 2004	16	27	14
Apr 2004	16	26	19
May 2004	16	28	14
Jun 2004	4	28	12
Jul 2004	17	31	15
Aug 2004	23	22	19
Sep 2004	41	45	12
Oct 2004	9	54	17
Nov 2004	15	48	30
Dec 2004	15	47	13
Total 2004	202	519	218
Jan 2005	9	56	38
Feb 2005	9	42	24
Mar 2005	16	36	24
Apr 2005	15	19	23
May 2005	11	31	16
Jun 2005	7	17	8
Jul 2005	7	27	14
Aug 2005	4	25	18
Sep 2005	6	35	15
Oct 2005	7	35	17
Nov 2005	12	35	13
Dec 2005	13	29	18
Total 2005	116	387	228
Jan 2006	6	31	18
Feb 2006	6	32	19
Mar 2006	4	38	23
Apr 2006	4	31	18
May 2006	14	27	17
Jun 2006	15	22	12
Jul 2006	12	18	12
Aug 2006	7	14	12
Sep 2006	8	27	6
Oct 2006	11	31	16
Nov 2006	17	40	26
Dec 2006	9	27	20
Total 2006	113	338	199
Jan 2007	14	22	28
Feb 2007	20	46	18
Mar 2007	21	33	29
Apr 2007	19	21	27
May 2007	15	19	16
Jun 2007	3	18	11
Jul 2007	7	16	21
Aug 2007	7	20	13
Sep 2007	13	32	33
Oct 2007	17	20	25
Nov 2007	13	29	24
Dec 2007	18	23	35
Total 2007	167	299	280
Jan 2008	3	14	18
Feb 2008	15	21	25
Mar 2008	12	16	17
Apr 2008	19	31	30
May 2008	10	20	24
Jun 2008	12	14	10
Jul 2008	11	12	13
Aug 2008	10	12	12
Sep 2008	19	22	17
Oct 2008	29	18	22
Nov 2008	14	24	24
Dec 2008	7	10	12
Total 2008	161	214	224
Jan 2009	11	19	18
Feb 2009	8	14	8
Mar 2009	12	25	27
Apr 2009	11	19	18
May 2009	8	11	21
Jun 2009	8	35	28
Jul 2009	15	28	24
Aug 2009	18	24	24
Sep 2009	8	15	11
Oct 2009	18	18	20
Nov 2009	20	20	28
Dec 2009	15	13	14
Total 2009	152	241	241
Jan 2010	21	21	22
Feb 2010	21	20	17
Mar 2010	28	37	22
Apr 2010	8	21	15
May 2010	11	25	19
Jun 2010	6	11	14
Jul 2010	4	13	11
Aug 2010	17	36	24
Sep 2010	15	26	18
Oct 2010	13	36	29
Nov 2010	16	32	18
Dec 2010	16	40	13
Total 2010	176	318	222
Jan 2011	15	32	27
Feb 2011	9	34	12
Mar 2011	15	35	19
Apr 2011	35	48	25
May 2011	39	34	34
Jun 2011	36	25	27
Jul 2011	24	17	23
Aug 2011	48	33	35
Sep 2011	49	29	26
Oct 2011	48	40	29
Nov 2011	44	32	21
Dec 2011	30	36	27
Total 2011	392	395	305
Jan 2012	27	28	11
Feb 2012	24	25	22
Mar 2012	21	59	60
Apr 2012	19	33	43
May 2012	26	44	43
Jun 2012	23	27	20
Jul 2012	8	22	21
Aug 2012	10	18	16
Sep 2012	19	26	11
Oct 2012	11	37	28
Nov 2012	32	21	32
Dec 2012	38	19	23
Total 2012	258	359	330
Jan 2013	16	31	15
Feb 2013	24	16	10
Mar 2013	16	28	37
Apr 2013	20	22	32
May 2013	14	36	43
Jun 2013	9	17	41
Jul 2013	11	17	28
Aug 2013	9	19	22
Sep 2013	16	24	29
Oct 2013	26	34	31
Nov 2013	13	29	32
Dec 2013	10	23	31
Total 2013	184	296	351
Jan 2014	17	22	27
Feb 2014	23	26	34
Mar 2014	25	27	31
Apr 2014	43	35	44
May 2014	29	39	45
Jun 2014	16	42	38
Jul 2014	26	45	40
Aug 2014	16	30	44
Sep 2014	20	55	31
Oct 2014	28	44	48
Nov 2014	42	44	45
Dec 2014	34	31	46
Total 2014	319	440	473
Jan 2015	8	22	41
Feb 2015	21	65	42
Mar 2015	72	31	50
Apr 2015	23	51	49
May 2015	43	42	50
Jun 2015	37	43	32
Jul 2015	12	35	37
Aug 2015	14	32	36
Sep 2015	28	65	42
Oct 2015	37	92	67
Nov 2015	26	38	73
Dec 2015	30	13	23
Total 2015	351	529	542
Jan 2016	33	26	29
Feb 2016	29	63	61
Mar 2016	22	34	44
Apr 2016	25	37	40
May 2016	58	57	47
Jun 2016	30	25	40
Jul 2016	19	28	32
Aug 2016	10	44	38
Sep 2016	17	54	41
Oct 2016	8	77	30
Nov 2016	4	60	31
Dec 2016	2	53	21
Total 2016	257	558	454
Jan 2017	5	52	10
Feb 2017	14	64	27
Mar 2017	15	73	25
Apr 2017	10	42	22
May 2017	5	134	24
Jun 2017	13	42	19
Jul 2017	18	42	24
Aug 2017	9	24	10
Sep 2017	6	30	14
Oct 2017	21	57	17
Nov 2017	10	35	10
Dec 2017	17	37	18
Total 2017	143	632	220
Jan 2018	11	44	23
Feb 2018	7	39	11
Mar 2018	20	21	39
Apr 2018	10	46	38
May 2018	9	109	20
Jun 2018	8	45	22
Jul 2018	8	38	18
Aug 2018	10	39	12
Sep 2018	11	38	17
Oct 2018	15	57	19
Nov 2018	8	40	19
Dec 2018	5	37	9
Total 2018	122	553	247
Jan 2019	9	35	16
Feb 2019	7	40	24
Mar 2019	8	37	21
Apr 2019	11	54	24
May 2019	6	54	23
Jun 2019	7	47	24
Jul 2019	4	33	20
Aug 2019	9	78	20
Sep 2019	7	125	24
Oct 2019	14	197	19
Nov 2019	18	86	33
Dec 2019	3	30	16
Total 2019	103	816	264
Jan 2020	5	55	16
Feb 2020	15	28	14
Mar 2020	4	39	12
Apr 2020	9	39	23
May 2020	2	40	20
Jun 2020	9	32	11
Jul 2020	5	25	9
Aug 2020	3	36	9
Sep 2020	2	104	9
Oct 2020	7	61	25
Total 2020	61	459	148
Total	3469	8201	5722