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Dynamic Changes in Nucleus Accumbens Dopamine Efflux During the Coolidge Effect in Male Rats

Dennis F. Fiorino, Ariane Coury and Anthony G. Phillips
Journal of Neuroscience 15 June 1997, 17 (12) 4849-4855; DOI: https://doi.org/10.1523/JNEUROSCI.17-12-04849.1997
Dennis F. Fiorino
1Psychology Department, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4  
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Ariane Coury
1Psychology Department, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4  
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Anthony G. Phillips
1Psychology Department, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4  
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    Fig. 1.

    Nucleus accumbens neurochemical correlates of sexual behavior during the Coolidge effect. The first eight samples represent chronologically continuous data points from phases 1 to 3. Sample 1 is the fourth and last precopulation baseline samples (Bas). Sample 2 represents introduction of female 1 behind the screen (Scr). After 15 min, the screen was removed, and rats were allowed to copulate (samples 3–8). Thebreak on the x-axis corresponds to the exclusion of data from three rats that copulated for extended periods with the initial female. The last nine samples were also continuous chronologically. Samples 9 and 10 correspond to the satiation period of phase 3 (i.e., 30 min without a mount). Female 1 was then reinserted behind the screen (sample 11) and, 15 min later, the screen was removed (sample 12). After 15 min devoid of copulation, female 2 was placed behind the screen (sample 13). Samples 14–17 correspond to copulation with female 2. The number of mounts, intromissions, or ejaculations associated with each 15 min microdialysis sample are shown in the bottom bar graph. Neurochemical data are expressed in terms of percentage of baseline concentrations. Changes in NAC DA (closed squares), DOPAC (closed circles), and HVA (open circles) efflux are presented as line graphs. The following comparisons were made: baseline sample 1 versus samples 2–10; new baseline sample 10 versus samples 11 and 12; new baseline sample 12 versus samples 13–17 (*p < 0.05; ** p < 0.01). Independent t tests were made between baseline values (samples 1, 10, and 12). For significant differences from the first baseline (sample 1), †p < 0.05.

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    Fig. 2.

    Location of microdialysis probes within the NAC of male rats used in the Coolidge effect experiment. Shaded rectangles correspond to the exposed membrane area of the microdialysis probes. Serial coronal brain sections were redrawn fromPaxinos and Watson (1986).

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    Table 1.

    Behavior during the Coolidge effect experiment

    Measure of sexual behaviorFemale 1Female 2
    Mount latency31.2  ± 10.3 sec54.4  ± 30.3 sec
    Intromission latency31.2  ± 10.3 sec156.4  ± 75.6 sec
    Ejaculation latency534.4  ± 111.4 sec512.0  ± 195.9 sec, (n = 2)
    Postejaculatory interval414.8  ± 51.8 sec850.0  ± 53.0 sec, (n = 2)
    Number of mounts (1st hr)16.0  ± 2.111.4  ± 4.5
    Number of intromissions (1st hr)37.0  ± 3.311.2  ± 4.5*
    Number of ejaculations (1st hr)4.2  ± 0.50.6  ± 0.41-160
    Interaction with female 1:
     Number of ejaculations (total)  7.8  ± 0.5 (range, 6–11)
     Time to sexual satiety144.0  ± 14.7 min (range, 105–195)
     Number of presentations  2.0  ± 0.5 (range, 1–4)
    • Values are presented as means ± S.E.M. (n = 5, except where indicated). The mount latency, intromission latency, ejaculation latency, and postejaculatory interval are derived from the first copulatory bout with each female.

    • ↵* p < 0.05;

    • ↵F1-160 p< 0.01.

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The Journal of Neuroscience: 17 (12)
Journal of Neuroscience
Vol. 17, Issue 12
15 Jun 1997
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Dynamic Changes in Nucleus Accumbens Dopamine Efflux During the Coolidge Effect in Male Rats
Dennis F. Fiorino, Ariane Coury, Anthony G. Phillips
Journal of Neuroscience 15 June 1997, 17 (12) 4849-4855; DOI: 10.1523/JNEUROSCI.17-12-04849.1997

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Dynamic Changes in Nucleus Accumbens Dopamine Efflux During the Coolidge Effect in Male Rats
Dennis F. Fiorino, Ariane Coury, Anthony G. Phillips
Journal of Neuroscience 15 June 1997, 17 (12) 4849-4855; DOI: 10.1523/JNEUROSCI.17-12-04849.1997
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Keywords

  • sexual behavior
  • nucleus accumbens
  • microdialysis
  • dopamine (DA)
  • dihydroxyphenylacetic acid (DOPAC)
  • homovanillic acid (HVA)
  • rat
  • sexual satiation
  • Coolidge effect
  • incentive motivation
  • copulation
  • reward
  • appetitive
  • consummatory
  • mesolimbic
  • exhaustion
  • novelty

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