Sonic Hedgehog Promotes the Survival of Specific CNS Neuron Populations and Protects These Cells from Toxic Insult In Vitro

We thank Drs. D. Melton, T. Jessell, C. Tabin, and T. Ingolia for critical review of this manuscript; A. McMahon and M. Scott forin situ probe templates; A. McMahon and T. Jessell for antibodies; and H. Roelink for Shh-encoding baculovirus. We also thank P. Jin for advice on QC-PCR.
Correspondence should be addressed to Kevin Pang, Ontogeny, Inc., 45 Moulton Street, Cambridge, MA 02138.

Statistics from Altmetric.com

Article usage

Select a custom date range for the past year

Article usage: January 1999 to February 2020

	Abstract	Full	Pdf
Jan 1999	0	10	6
Feb 1999	4	20	16
Mar 1999	3	10	10
Dec 1999	2	6	3
Total 1999	9	46	35
Jan 2000	5	17	14
Feb 2000	2	19	8
Mar 2000	2	8	5
Apr 2000	1	12	11
May 2000	3	9	10
Jun 2000	0	9	5
Jul 2000	1	9	2
Aug 2000	3	8	8
Sep 2000	2	6	2
Oct 2000	5	15	13
Nov 2000	5	6	3
Dec 2000	2	6	3
Total 2000	31	124	84
Jan 2001	5	23	8
Feb 2001	2	8	5
Mar 2001	1	9	5
Apr 2001	1	18	10
May 2001	1	18	11
Jun 2001	2	7	7
Jul 2001	3	14	18
Aug 2001	0	7	2
Sep 2001	0	8	10
Oct 2001	0	12	6
Nov 2001	3	12	12
Dec 2001	4	8	9
Total 2001	22	144	103
Jan 2002	0	6	4
Feb 2002	2	8	9
Mar 2002	0	12	13
Apr 2002	5	19	26
May 2002	1	10	16
Jun 2002	0	8	12
Jul 2002	0	5	4
Aug 2002	2	8	15
Sep 2002	0	9	12
Oct 2002	2	13	10
Nov 2002	1	4	5
Dec 2002	0	13	11
Total 2002	13	115	137
Jan 2003	3	9	13
Feb 2003	0	11	8
Mar 2003	3	13	25
Apr 2003	0	6	10
May 2003	2	21	20
Jun 2003	2	15	22
Jul 2003	6	21	16
Aug 2003	8	11	18
Sep 2003	10	16	9
Oct 2003	8	14	7
Nov 2003	13	20	14
Dec 2003	17	33	19
Total 2003	72	190	181
Jan 2004	19	35	15
Feb 2004	16	13	9
Mar 2004	15	29	14
Apr 2004	12	43	16
May 2004	12	20	12
Jun 2004	13	24	10
Jul 2004	12	20	9
Aug 2004	16	23	11
Sep 2004	14	38	27
Oct 2004	12	42	11
Nov 2004	19	34	13
Dec 2004	21	47	10
Total 2004	181	368	157
Jan 2005	19	16	5
Feb 2005	23	16	3
Mar 2005	13	33	19
Apr 2005	7	18	9
May 2005	10	25	8
Jun 2005	10	15	9
Jul 2005	16	17	10
Aug 2005	7	17	12
Sep 2005	6	19	13
Oct 2005	8	23	9
Nov 2005	6	26	9
Dec 2005	10	18	2
Total 2005	135	243	108
Jan 2006	10	14	2
Feb 2006	19	26	14
Mar 2006	6	16	5
Apr 2006	5	16	13
May 2006	9	9	11
Jun 2006	7	13	10
Jul 2006	3	4	1
Aug 2006	7	8	1
Sep 2006	10	15	4
Oct 2006	13	18	14
Nov 2006	11	31	15
Dec 2006	9	13	10
Total 2006	109	183	100
Jan 2007	12	16	17
Feb 2007	19	6	8
Mar 2007	19	28	12
Apr 2007	4	16	21
May 2007	5	14	25
Jun 2007	3	17	10
Jul 2007	5	11	7
Aug 2007	4	7	6
Sep 2007	6	11	4
Oct 2007	1	10	7
Nov 2007	11	18	14
Dec 2007	5	4	2
Total 2007	94	158	133
Jan 2008	3	16	5
Feb 2008	6	9	8
Mar 2008	6	11	14
Apr 2008	7	9	8
May 2008	6	13	10
Jun 2008	14	12	14
Jul 2008	4	11	10
Aug 2008	1	8	8
Sep 2008	7	4	5
Oct 2008	21	13	13
Nov 2008	11	5	8
Dec 2008	5	9	5
Total 2008	91	120	108
Jan 2009	5	5	7
Feb 2009	1	6	7
Mar 2009	4	10	12
Apr 2009	6	7	5
May 2009	5	6	8
Jun 2009	4	8	9
Jul 2009	6	5	9
Aug 2009	5	7	7
Sep 2009	4	5	10
Oct 2009	7	12	12
Nov 2009	11	9	9
Dec 2009	7	8	5
Total 2009	65	88	100
Jan 2010	8	9	9
Feb 2010	4	4	2
Mar 2010	8	12	9
Apr 2010	1	15	11
May 2010	0	18	10
Jun 2010	1	16	3
Jul 2010	2	11	6
Aug 2010	2	22	8
Sep 2010	6	5	6
Oct 2010	2	21	3
Nov 2010	10	28	7
Dec 2010	11	10	6
Total 2010	55	171	80
Jan 2011	6	10	11
Feb 2011	8	9	12
Mar 2011	9	15	7
Apr 2011	7	19	13
May 2011	12	12	14
Jun 2011	13	9	19
Jul 2011	6	3	12
Aug 2011	5	7	12
Sep 2011	8	14	24
Oct 2011	10	12	17
Nov 2011	7	11	9
Dec 2011	6	12	9
Total 2011	97	133	159
Jan 2012	12	10	15
Feb 2012	11	14	25
Mar 2012	20	18	21
Apr 2012	4	11	9
May 2012	12	11	13
Jun 2012	11	8	6
Jul 2012	11	2	10
Aug 2012	4	8	14
Sep 2012	7	16	8
Oct 2012	11	17	18
Nov 2012	17	7	22
Dec 2012	36	16	13
Total 2012	156	138	174
Jan 2013	9	5	13
Feb 2013	25	5	11
Mar 2013	9	7	6
Apr 2013	9	7	15
May 2013	4	3	18
Jun 2013	6	6	14
Jul 2013	1	3	10
Aug 2013	3	2	17
Sep 2013	6	3	22
Oct 2013	6	4	14
Nov 2013	1	0	9
Dec 2013	1	1	13
Total 2013	80	46	162
Jan 2014	9	5	28
Feb 2014	5	4	36
Mar 2014	3	3	39
Apr 2014	6	4	30
May 2014	6	5	32
Jun 2014	4	3	24
Jul 2014	12	14	47
Aug 2014	5	2	28
Sep 2014	6	6	23
Oct 2014	8	12	16
Nov 2014	6	5	15
Dec 2014	6	10	18
Total 2014	76	73	336
Jan 2015	7	4	23
Feb 2015	11	7	37
Mar 2015	6	10	21
Apr 2015	4	13	20
May 2015	2	12	18
Jun 2015	1	6	13
Jul 2015	6	10	9
Aug 2015	5	8	15
Sep 2015	6	5	20
Oct 2015	7	10	14
Nov 2015	7	7	16
Dec 2015	5	6	13
Total 2015	67	98	219
Jan 2016	5	10	19
Feb 2016	9	13	23
Mar 2016	10	15	37
Apr 2016	6	9	16
May 2016	5	7	8
Jun 2016	6	16	14
Jul 2016	5	11	10
Aug 2016	10	8	11
Sep 2016	3	6	8
Oct 2016	17	12	11
Nov 2016	8	13	23
Dec 2016	4	10	18
Total 2016	88	130	198
Jan 2017	3	17	27
Feb 2017	3	8	16
Mar 2017	4	25	28
Apr 2017	5	14	23
May 2017	5	34	11
Jun 2017	4	10	9
Jul 2017	4	14	5
Aug 2017	7	13	9
Sep 2017	6	11	7
Oct 2017	4	8	6
Nov 2017	4	14	7
Dec 2017	7	9	5
Total 2017	56	177	153
Jan 2018	5	11	10
Feb 2018	7	8	7
Mar 2018	5	8	7
Apr 2018	6	15	7
May 2018	5	20	6
Jun 2018	6	23	7
Jul 2018	11	10	8
Aug 2018	5	11	6
Sep 2018	6	20	5
Oct 2018	4	12	4
Nov 2018	4	13	6
Dec 2018	6	15	8
Total 2018	70	166	81
Jan 2019	5	10	6
Feb 2019	4	12	3
Mar 2019	5	14	5
Apr 2019	6	10	5
May 2019	5	12	4
Jun 2019	2	14	8
Jul 2019	6	12	10
Aug 2019	4	11	5
Sep 2019	2	9	5
Oct 2019	6	24	3
Nov 2019	6	11	9
Dec 2019	5	15	8
Total 2019	56	154	71
Jan 2020	5	20	6
Feb 2020	1	5	3
Total 2020	6	25	9
Total	1629	3090	2888