Nerve Growth Factor Treatment Increases Brain-Derived Neurotrophic Factor Selectively in TrkA-Expressing Dorsal Root Ganglion Cells and in Their Central Terminations within the Spinal Cord

G. J. Michael; S. Averill; A. Nitkunan; M. Rattray; D. L. H. Bennett; Q. Yan; J. V. Priestley

doi:10.1523/JNEUROSCI.17-21-08476.1997

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.17-21-08476.1997

PubMed

9334420

Published By

Society for Neuroscience

History

Received April 23, 1997
Revision received July 21, 1997
Accepted August 12, 1997
First published November 1, 1997.

Version of record published November 1, 1997.

Author Information

G. J. Michael1,
S. Averill1,
A. Nitkunan2,
M. Rattray3,
D. L. H. Bennett2,
Q. Yan4, and
J. V. Priestley1

¹Department of Anatomy, Faculty of Basic Medical Sciences, Queen Mary and Westfield College, London 31 4NS, United Kingdom, Departments of
²Physiology and
³Biochemistry, United Medical and Dental Schools, St. Thomas’s Hospital Medical School Campus, London SE1 7EH, United Kingdom, and
⁴Amgen Inc., Amgen Centre, Thousand Oaks, California 91320-1789

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Author contributions

Disclosures

Received April 23, 1997.
Revision received July 21, 1997.
Accepted August 12, 1997.

This work was supported by the Medical Research Council (UK) and the Wellcome Trust. We thank Professor J. M. Polak and Dr. D. O. Clary for provision of rabbit CGRP and trkA antibodies. Human recombinant NGF was a generous gift of Genentech Inc.
Correspondence should be addressed to Professor J. V. Priestley, Department of Anatomy, Faculty of Basic Medical Sciences, Queen Mary and Westfield College, Mile End Road, London E1 4NS, UK.

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	Abstract	Full	Pdf
Jan 1999	1	12	14
Feb 1999	6	19	8
Mar 1999	3	14	6
Dec 1999	3	15	6
Total 1999	13	60	34
Jan 2000	9	25	25
Feb 2000	4	23	8
Mar 2000	5	25	16
Apr 2000	3	35	34
May 2000	4	22	18
Jun 2000	3	27	17
Jul 2000	4	28	17
Aug 2000	4	25	27
Sep 2000	7	19	19
Oct 2000	10	49	33
Nov 2000	4	40	25
Dec 2000	9	11	12
Total 2000	66	329	251
Jan 2001	2	23	21
Feb 2001	14	60	55
Mar 2001	4	29	23
Apr 2001	11	37	42
May 2001	14	36	28
Jun 2001	5	18	10
Jul 2001	3	22	23
Aug 2001	10	29	26
Sep 2001	4	16	10
Oct 2001	7	29	25
Nov 2001	4	26	19
Dec 2001	2	13	27
Total 2001	80	338	309
Jan 2002	4	22	13
Feb 2002	2	18	17
Mar 2002	7	31	24
Apr 2002	7	21	18
May 2002	3	26	32
Jun 2002	2	24	30
Jul 2002	1	13	19
Aug 2002	1	15	16
Sep 2002	2	19	19
Oct 2002	5	24	31
Nov 2002	2	7	12
Dec 2002	0	11	27
Total 2002	36	231	258
Jan 2003	1	42	68
Feb 2003	1	16	21
Mar 2003	11	21	35
Apr 2003	5	29	32
May 2003	7	28	32
Jun 2003	9	18	22
Jul 2003	8	33	27
Aug 2003	10	31	30
Sep 2003	9	28	16
Oct 2003	17	41	22
Nov 2003	19	49	57
Dec 2003	12	35	35
Total 2003	109	371	397
Jan 2004	15	32	26
Feb 2004	15	36	46
Mar 2004	20	45	36
Apr 2004	23	49	32
May 2004	16	36	31
Jun 2004	8	38	38
Jul 2004	16	23	21
Aug 2004	14	26	17
Sep 2004	22	42	28
Oct 2004	19	27	31
Nov 2004	14	48	36
Dec 2004	17	31	29
Total 2004	199	433	371
Jan 2005	18	49	39
Feb 2005	11	29	24
Mar 2005	15	28	29
Apr 2005	8	36	25
May 2005	8	43	33
Jun 2005	11	30	34
Jul 2005	14	31	19
Aug 2005	8	47	32
Sep 2005	10	41	23
Oct 2005	7	43	51
Nov 2005	6	46	32
Dec 2005	10	29	21
Total 2005	126	452	362
Jan 2006	9	47	33
Feb 2006	4	40	23
Mar 2006	6	54	48
Apr 2006	10	36	20
May 2006	31	33	22
Jun 2006	13	35	25
Jul 2006	20	26	22
Aug 2006	14	26	14
Sep 2006	22	22	27
Oct 2006	21	43	34
Nov 2006	18	33	40
Dec 2006	18	32	14
Total 2006	186	427	322
Jan 2007	20	28	20
Feb 2007	19	17	25
Mar 2007	19	16	23
Apr 2007	15	13	12
May 2007	15	23	30
Jun 2007	5	23	21
Jul 2007	13	18	12
Aug 2007	9	25	14
Sep 2007	17	25	26
Oct 2007	22	23	40
Nov 2007	22	29	25
Dec 2007	13	19	25
Total 2007	189	259	273
Jan 2008	8	20	21
Feb 2008	13	31	23
Mar 2008	15	19	21
Apr 2008	9	28	22
May 2008	8	19	18
Jun 2008	11	24	23
Jul 2008	10	6	16
Aug 2008	9	12	12
Sep 2008	15	21	21
Oct 2008	31	16	13
Nov 2008	19	11	19
Dec 2008	11	5	17
Total 2008	159	212	226
Jan 2009	16	18	18
Feb 2009	14	20	28
Mar 2009	12	21	23
Apr 2009	20	18	23
May 2009	10	18	10
Jun 2009	17	15	23
Jul 2009	8	13	16
Aug 2009	4	18	15
Sep 2009	7	12	9
Oct 2009	16	21	20
Nov 2009	16	28	28
Dec 2009	14	8	14
Total 2009	154	210	227
Jan 2010	13	50	29
Feb 2010	19	18	18
Mar 2010	19	18	29
Apr 2010	22	33	18
May 2010	5	23	23
Jun 2010	10	7	3
Jul 2010	4	21	9
Aug 2010	5	26	12
Sep 2010	10	28	16
Oct 2010	23	42	35
Nov 2010	20	37	17
Dec 2010	12	33	13
Total 2010	162	336	222
Jan 2011	9	26	20
Feb 2011	16	26	47
Mar 2011	19	33	16
Apr 2011	19	21	15
May 2011	13	23	16
Jun 2011	13	16	10
Jul 2011	19	17	17
Aug 2011	13	15	21
Sep 2011	32	10	21
Oct 2011	13	39	18
Nov 2011	17	27	27
Dec 2011	13	33	19
Total 2011	196	286	247
Jan 2012	22	23	17
Feb 2012	18	16	15
Mar 2012	25	19	13
Apr 2012	43	16	30
May 2012	20	20	22
Jun 2012	21	16	33
Jul 2012	15	35	31
Aug 2012	20	15	23
Sep 2012	14	5	19
Oct 2012	23	15	26
Nov 2012	44	17	28
Dec 2012	31	20	24
Total 2012	296	217	281
Jan 2013	18	22	36
Feb 2013	28	17	30
Mar 2013	31	22	46
Apr 2013	16	11	27
May 2013	26	11	44
Jun 2013	7	8	22
Jul 2013	16	7	21
Aug 2013	11	11	26
Sep 2013	16	12	33
Oct 2013	22	13	33
Nov 2013	23	12	28
Dec 2013	11	6	30
Total 2013	225	152	376
Jan 2014	25	12	33
Feb 2014	18	19	19
Mar 2014	18	11	30
Apr 2014	17	12	16
May 2014	20	16	13
Jun 2014	25	19	19
Jul 2014	32	16	24
Aug 2014	14	5	12
Sep 2014	20	15	24
Oct 2014	17	24	14
Nov 2014	21	6	13
Dec 2014	13	25	9
Total 2014	240	180	226
Jan 2015	18	14	17
Feb 2015	19	15	24
Mar 2015	24	9	63
Apr 2015	26	9	17
May 2015	21	11	14
Jun 2015	25	9	13
Jul 2015	19	28	17
Aug 2015	15	9	10
Sep 2015	204	12	18
Oct 2015	11	10	8
Nov 2015	24	11	13
Dec 2015	18	7	13
Total 2015	424	144	227
Jan 2016	42	17	22
Feb 2016	31	5	18
Mar 2016	37	14	36
Apr 2016	22	21	17
May 2016	21	10	28
Jun 2016	19	16	16
Jul 2016	16	12	15
Aug 2016	14	3	12
Sep 2016	19	7	21
Oct 2016	13	16	13
Nov 2016	22	12	15
Dec 2016	13	11	11
Total 2016	269	144	224
Jan 2017	9	22	17
Feb 2017	9	13	20
Mar 2017	9	39	14
Apr 2017	11	15	54
May 2017	13	82	37
Jun 2017	6	25	13
Jul 2017	5	12	6
Aug 2017	6	14	7
Sep 2017	10	16	7
Oct 2017	19	18	8
Nov 2017	9	25	13
Dec 2017	8	19	5
Total 2017	114	300	201
Jan 2018	3	13	14
Feb 2018	10	16	11
Mar 2018	16	20	14
Apr 2018	7	23	18
May 2018	1	23	3
Jun 2018	2	44	16
Jul 2018	5	17	17
Aug 2018	2	16	5
Sep 2018	13	18	10
Oct 2018	4	21	24
Nov 2018	7	15	23
Dec 2018	3	162	16
Total 2018	73	388	171
Jan 2019	3	276	14
Feb 2019	7	14	8
Mar 2019	18	15	9
Apr 2019	8	27	37
May 2019	9	29	10
Jun 2019	9	16	9
Jul 2019	5	16	12
Aug 2019	8	17	11
Sep 2019	4	39	16
Oct 2019	13	97	10
Nov 2019	12	39	13
Dec 2019	9	27	10
Total 2019	105	612	159
Jan 2020	6	37	5
Feb 2020	2	15	6
Mar 2020	4	15	4
Apr 2020	4	5	2
May 2020	6	14	13
Jun 2020	1	13	4
Jul 2020	1	15	3
Aug 2020	5	14	6
Sep 2020	5	47	1
Oct 2020	9	38	6
Nov 2020	10	43	5
Dec 2020	11	29	14
Total 2020	64	285	69
Jan 2021	9	41	14
Feb 2021	4	49	14
Mar 2021	0	3	3
Total 2021	13	93	31
Total	3498	6459	5464