Estradiol Increases the Sensitivity of Hippocampal CA1 Pyramidal Cells to NMDA Receptor-Mediated Synaptic Input: Correlation with Dendritic Spine Density

Catherine S. Woolley; Nancy G. Weiland; Bruce S. McEwen; Philip A. Schwartzkroin

doi:10.1523/JNEUROSCI.17-05-01848.1997

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.17-05-01848.1997

PubMed

9030643

Published By

Society for Neuroscience

History

Received September 12, 1996
Revision received December 12, 1996
Accepted December 19, 1996
First published March 1, 1997.

Version of record published March 1, 1997.

Author Information

Catherine S. Woolley1,
Nancy G. Weiland2,
Bruce S. McEwen2, and
Philip A. Schwartzkroin1

¹Department of Neurological Surgery, University of Washington, Seattle, Washington 98195, and
²Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021

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Author contributions

Disclosures

Received September 12, 1996.
Revision received December 12, 1996.
Accepted December 19, 1996.

This research was supported by National Institutes of Health Grants NS 18895 to P.A.S. and NS 09787 to C.S.W.
Correspondence should be addressed to Catherine S. Woolley, Department of Neurological Surgery, Box 356470, University of Washington, Seattle, WA 98195.

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	Abstract	Full	Pdf
Jan 1999	4	11	10
Feb 1999	6	10	5
Mar 1999	4	17	24
Dec 1999	6	21	15
Total 1999	20	59	54
Jan 2000	9	25	11
Feb 2000	6	24	18
Mar 2000	6	37	32
Apr 2000	5	20	15
May 2000	3	23	12
Jun 2000	2	16	16
Jul 2000	3	25	19
Aug 2000	7	11	12
Sep 2000	10	25	27
Oct 2000	5	21	12
Nov 2000	26	77	42
Dec 2000	9	46	24
Total 2000	91	350	240
Jan 2001	14	54	28
Feb 2001	3	33	26
Mar 2001	9	49	28
Apr 2001	5	32	26
May 2001	8	46	24
Jun 2001	5	19	12
Jul 2001	2	23	23
Aug 2001	9	24	27
Sep 2001	8	29	10
Oct 2001	6	54	27
Nov 2001	7	37	30
Dec 2001	8	27	18
Total 2001	84	427	279
Jan 2002	10	29	20
Feb 2002	16	16	11
Mar 2002	1	29	24
Apr 2002	10	28	17
May 2002	13	18	18
Jun 2002	4	19	15
Jul 2002	5	19	18
Aug 2002	6	12	20
Sep 2002	6	19	22
Oct 2002	4	38	34
Nov 2002	11	22	42
Dec 2002	3	17	17
Total 2002	89	266	258
Jan 2003	8	21	21
Feb 2003	5	35	38
Mar 2003	4	39	41
Apr 2003	4	42	25
May 2003	5	29	30
Jun 2003	3	30	17
Jul 2003	11	95	19
Aug 2003	6	54	14
Sep 2003	6	72	14
Oct 2003	18	63	20
Nov 2003	14	73	31
Dec 2003	12	89	28
Total 2003	96	642	298
Jan 2004	28	79	31
Feb 2004	20	64	24
Mar 2004	21	42	34
Apr 2004	29	58	33
May 2004	23	60	22
Jun 2004	19	30	20
Jul 2004	9	47	24
Aug 2004	19	23	12
Sep 2004	21	48	29
Oct 2004	18	38	16
Nov 2004	14	66	35
Dec 2004	8	33	15
Total 2004	229	588	295
Jan 2005	15	32	33
Feb 2005	8	28	15
Mar 2005	12	36	22
Apr 2005	2	18	35
May 2005	8	30	26
Jun 2005	9	20	13
Jul 2005	4	22	13
Aug 2005	7	32	18
Sep 2005	8	30	16
Oct 2005	10	38	19
Nov 2005	8	28	19
Dec 2005	8	24	19
Total 2005	99	338	248
Jan 2006	5	30	16
Feb 2006	6	27	23
Mar 2006	7	35	25
Apr 2006	13	32	24
May 2006	13	22	27
Jun 2006	14	15	13
Jul 2006	12	15	14
Aug 2006	8	13	9
Sep 2006	14	16	18
Oct 2006	13	20	14
Nov 2006	22	36	45
Dec 2006	6	23	14
Total 2006	133	284	242
Jan 2007	11	16	9
Feb 2007	6	16	18
Mar 2007	16	24	21
Apr 2007	7	14	8
May 2007	10	22	11
Jun 2007	11	20	19
Jul 2007	16	21	9
Aug 2007	5	21	9
Sep 2007	14	14	14
Oct 2007	11	14	12
Nov 2007	7	22	17
Dec 2007	11	10	14
Total 2007	125	214	161
Jan 2008	12	16	13
Feb 2008	11	19	16
Mar 2008	12	26	33
Apr 2008	17	23	26
May 2008	7	14	14
Jun 2008	22	18	26
Jul 2008	13	9	12
Aug 2008	7	10	13
Sep 2008	10	3	15
Oct 2008	24	22	25
Nov 2008	11	6	11
Dec 2008	11	9	10
Total 2008	157	175	214
Jan 2009	16	19	21
Feb 2009	10	20	17
Mar 2009	9	20	20
Apr 2009	11	17	12
May 2009	14	5	21
Jun 2009	11	12	13
Jul 2009	17	12	8
Aug 2009	11	15	13
Sep 2009	11	20	16
Oct 2009	18	16	15
Nov 2009	16	15	22
Dec 2009	16	20	7
Total 2009	160	191	185
Jan 2010	17	19	16
Feb 2010	13	10	10
Mar 2010	19	23	24
Apr 2010	17	21	22
May 2010	11	26	24
Jun 2010	11	31	26
Jul 2010	13	23	16
Aug 2010	8	23	11
Sep 2010	6	18	13
Oct 2010	9	5	2
Nov 2010	16	44	20
Dec 2010	12	17	11
Total 2010	152	260	195
Jan 2011	12	29	23
Feb 2011	10	24	15
Mar 2011	13	29	24
Apr 2011	12	26	26
May 2011	15	21	15
Jun 2011	11	10	16
Jul 2011	20	11	18
Aug 2011	15	11	13
Sep 2011	20	16	19
Oct 2011	15	24	19
Nov 2011	11	16	27
Dec 2011	17	29	18
Total 2011	171	246	233
Jan 2012	20	15	21
Feb 2012	11	17	28
Mar 2012	23	20	29
Apr 2012	16	18	19
May 2012	23	20	15
Jun 2012	7	7	17
Jul 2012	15	8	10
Aug 2012	7	20	16
Sep 2012	9	10	13
Oct 2012	12	9	17
Nov 2012	34	9	8
Dec 2012	34	14	17
Total 2012	211	167	210
Jan 2013	18	19	17
Feb 2013	18	21	42
Mar 2013	26	11	38
Apr 2013	38	19	28
May 2013	20	12	29
Jun 2013	24	11	33
Jul 2013	14	11	16
Aug 2013	11	9	32
Sep 2013	24	7	37
Oct 2013	24	18	30
Nov 2013	20	30	53
Dec 2013	23	24	80
Total 2013	260	192	435
Jan 2014	21	14	41
Feb 2014	19	10	34
Mar 2014	21	13	48
Apr 2014	15	20	64
May 2014	21	12	37
Jun 2014	23	15	27
Jul 2014	38	41	35
Aug 2014	15	11	32
Sep 2014	13	16	34
Oct 2014	17	14	20
Nov 2014	15	20	25
Dec 2014	18	17	40
Total 2014	236	203	437
Jan 2015	32	20	20
Feb 2015	14	15	8
Mar 2015	24	25	18
Apr 2015	23	14	9
May 2015	14	9	23
Jun 2015	15	12	13
Jul 2015	19	24	20
Aug 2015	12	8	20
Sep 2015	72	15	17
Oct 2015	20	22	32
Nov 2015	25	6	25
Dec 2015	17	14	9
Total 2015	287	184	214
Jan 2016	12	13	5
Feb 2016	4	18	18
Mar 2016	22	19	23
Apr 2016	9	10	13
May 2016	17	17	20
Jun 2016	5	13	15
Jul 2016	6	15	16
Aug 2016	11	29	15
Sep 2016	6	12	9
Oct 2016	8	27	11
Nov 2016	13	16	14
Dec 2016	1	20	8
Total 2016	114	209	167
Jan 2017	10	25	13
Feb 2017	13	35	11
Mar 2017	9	36	12
Apr 2017	4	23	41
May 2017	18	84	31
Jun 2017	7	25	10
Jul 2017	5	17	10
Aug 2017	2	11	10
Sep 2017	10	15	13
Oct 2017	7	28	8
Nov 2017	9	35	14
Dec 2017	4	14	11
Total 2017	98	348	184
Jan 2018	10	21	8
Feb 2018	12	18	13
Mar 2018	8	20	12
Apr 2018	9	31	8
May 2018	3	36	13
Jun 2018	6	24	9
Jul 2018	7	19	11
Aug 2018	7	9	3
Sep 2018	7	25	9
Oct 2018	12	27	7
Nov 2018	5	30	9
Dec 2018	3	18	5
Total 2018	89	278	107
Jan 2019	8	110	9
Feb 2019	9	98	10
Mar 2019	14	65	27
Apr 2019	12	26	19
May 2019	6	27	20
Jun 2019	7	36	14
Jul 2019	5	18	16
Aug 2019	1	29	19
Sep 2019	6	46	14
Oct 2019	8	99	25
Nov 2019	5	29	12
Dec 2019	7	18	6
Total 2019	88	601	191
Jan 2020	6	29	10
Feb 2020	4	23	14
Mar 2020	3	34	3
Apr 2020	6	39	9
May 2020	7	19	10
Jun 2020	4	18	9
Jul 2020	6	10	5
Aug 2020	3	15	11
Sep 2020	5	36	13
Oct 2020	5	39	13
Nov 2020	10	29	22
Dec 2020	4	33	19
Total 2020	63	324	138
Jan 2021	2	48	18
Feb 2021	3	44	18
Mar 2021	10	31	27
Apr 2021	8	34	13
May 2021	8	44	18
Jun 2021	5	43	6
Jul 2021	8	25	17
Aug 2021	6	35	7
Sep 2021	15	36	20
Oct 2021	9	27	29
Nov 2021	6	22	18
Dec 2021	5	15	9
Total 2021	85	404	200
Jan 2022	2	24	8
Feb 2022	5	17	12
Mar 2022	7	24	8
Apr 2022	4	32	7
Total 2022	18	97	35
Total	3155	7047	5220