Rapid Exocytosis in Single Chromaffin Cells Recorded from Mouse Adrenal Slices

This work was supported by grants from the Human Frontiers Science Program (RG-4/95B) and the Deutsche Forschungsgemeinschaft (SFB 523) to E. Neher. We thank Drs. Kevin Gillis, Henrique v. Gersdorff, Corey Smith, and C. Matthes for critical feedback on this manuscript. We thank F. Friedlein and M. Pilot for expert technical assistance. We thank Dr. R. J. Bookman for providing the rat chromaffin cell data shown in Figure 3A.
Correspondence should be addressed to E. Neher at the above address.

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	Abstract	Full	Pdf
Jan 1999	1	10	4
Feb 1999	1	3	2
Mar 1999	1	4	7
Dec 1999	1	4	3
Total 1999	4	21	16
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Feb 2000	2	3	3
Mar 2000	1	9	12
Apr 2000	5	8	6
May 2000	3	16	10
Jun 2000	2	5	2
Jul 2000	1	7	5
Aug 2000	2	6	8
Sep 2000	1	13	9
Oct 2000	6	14	7
Nov 2000	8	14	10
Dec 2000	4	7	9
Total 2000	39	108	85
Jan 2001	3	10	13
Feb 2001	3	7	4
Mar 2001	6	15	8
Apr 2001	3	6	8
May 2001	3	11	6
Jun 2001	1	5	4
Jul 2001	5	10	9
Aug 2001	1	3	4
Sep 2001	3	12	5
Oct 2001	2	5	7
Nov 2001	1	8	4
Dec 2001	4	4	2
Total 2001	35	96	74
Jan 2002	2	7	10
Feb 2002	0	5	4
Mar 2002	1	9	7
Apr 2002	2	11	10
May 2002	1	5	5
Jun 2002	3	7	5
Jul 2002	1	8	6
Aug 2002	0	5	9
Sep 2002	1	9	14
Oct 2002	2	20	8
Nov 2002	1	6	5
Dec 2002	0	3	5
Total 2002	14	95	88
Jan 2003	3	8	9
Feb 2003	4	11	9
Mar 2003	0	4	5
Apr 2003	0	3	6
May 2003	2	5	5
Jun 2003	5	13	3
Jul 2003	5	9	1
Aug 2003	9	7	6
Sep 2003	9	18	7
Oct 2003	8	21	11
Nov 2003	13	15	7
Dec 2003	11	20	8
Total 2003	69	134	77
Jan 2004	24	21	10
Feb 2004	7	40	13
Mar 2004	18	21	11
Apr 2004	17	31	16
May 2004	17	24	8
Jun 2004	12	25	13
Jul 2004	12	19	9
Aug 2004	19	29	9
Sep 2004	11	31	6
Oct 2004	16	41	8
Nov 2004	7	56	10
Dec 2004	19	28	6
Total 2004	179	366	119
Jan 2005	7	37	10
Feb 2005	14	40	11
Mar 2005	14	15	6
Apr 2005	3	9	8
May 2005	12	17	7
Jun 2005	9	15	3
Jul 2005	6	19	5
Aug 2005	5	23	16
Sep 2005	1	9	6
Oct 2005	7	31	6
Nov 2005	5	15	4
Dec 2005	15	18	7
Total 2005	98	248	89
Jan 2006	3	30	9
Feb 2006	12	23	12
Mar 2006	3	16	8
Apr 2006	1	5	1
May 2006	2	11	2
Jun 2006	4	21	9
Jul 2006	6	11	12
Aug 2006	2	11	6
Sep 2006	5	26	6
Oct 2006	6	19	7
Nov 2006	8	21	8
Dec 2006	1	14	3
Total 2006	53	208	83
Jan 2007	8	17	11
Feb 2007	2	16	7
Mar 2007	4	24	12
Apr 2007	2	6	9
May 2007	1	20	11
Jun 2007	5	27	14
Jul 2007	3	14	8
Aug 2007	2	11	4
Sep 2007	3	16	1
Oct 2007	4	14	8
Nov 2007	6	12	5
Dec 2007	4	11	8
Total 2007	44	188	98
Jan 2008	12	12	14
Feb 2008	9	8	8
Mar 2008	9	8	6
Apr 2008	2	8	3
May 2008	3	4	5
Jun 2008	7	11	9
Jul 2008	4	10	6
Aug 2008	2	8	2
Sep 2008	5	9	3
Oct 2008	8	5	1
Nov 2008	5	19	13
Dec 2008	2	5	3
Total 2008	68	107	73
Jan 2009	5	7	6
Feb 2009	1	7	6
Mar 2009	5	11	13
Apr 2009	2	9	8
May 2009	2	5	4
Jun 2009	7	12	13
Jul 2009	4	11	5
Aug 2009	3	3	5
Sep 2009	3	6	10
Oct 2009	8	7	17
Nov 2009	6	12	8
Dec 2009	9	8	15
Total 2009	55	98	110
Jan 2010	6	6	9
Feb 2010	2	2	4
Mar 2010	3	7	3
Apr 2010	1	9	7
May 2010	4	10	7
Jun 2010	4	19	6
Jul 2010	1	10	9
Aug 2010	1	34	22
Sep 2010	4	9	11
Oct 2010	3	18	5
Nov 2010	13	25	13
Dec 2010	8	10	12
Total 2010	50	159	108
Jan 2011	8	19	14
Feb 2011	3	7	7
Mar 2011	6	17	12
Apr 2011	7	10	8
May 2011	7	9	9
Jun 2011	6	12	13
Jul 2011	3	12	13
Aug 2011	29	7	11
Sep 2011	34	2	6
Oct 2011	39	11	19
Nov 2011	19	17	15
Dec 2011	25	13	13
Total 2011	186	136	140
Jan 2012	25	9	19
Feb 2012	32	8	15
Mar 2012	29	8	17
Apr 2012	28	6	10
May 2012	23	4	20
Jun 2012	15	3	13
Jul 2012	21	15	12
Aug 2012	16	12	18
Sep 2012	15	2	15
Oct 2012	39	12	19
Nov 2012	32	2	11
Dec 2012	35	3	15
Total 2012	310	84	184
Jan 2013	34	7	14
Feb 2013	16	8	10
Mar 2013	17	2	9
Apr 2013	16	4	11
May 2013	21	3	18
Jun 2013	13	5	18
Jul 2013	10	1	13
Aug 2013	10	0	10
Sep 2013	17	5	13
Oct 2013	18	7	27
Nov 2013	12	0	32
Dec 2013	9	10	62
Total 2013	193	52	237
Jan 2014	27	6	25
Feb 2014	13	4	24
Mar 2014	16	6	31
Apr 2014	18	6	21
May 2014	21	5	32
Jun 2014	21	9	22
Jul 2014	31	7	17
Aug 2014	7	17	21
Sep 2014	13	11	18
Oct 2014	14	15	19
Nov 2014	24	14	35
Dec 2014	5	4	55
Total 2014	210	104	320
Jan 2015	11	9	38
Feb 2015	15	2	37
Mar 2015	21	7	33
Apr 2015	16	10	16
May 2015	24	1	7
Jun 2015	10	6	11
Jul 2015	22	5	10
Aug 2015	11	11	18
Sep 2015	29	5	24
Oct 2015	11	4	27
Nov 2015	18	22	9
Dec 2015	18	24	8
Total 2015	206	106	238
Jan 2016	10	11	16
Feb 2016	20	7	18
Mar 2016	21	8	25
Apr 2016	11	6	16
May 2016	23	10	15
Jun 2016	28	6	13
Jul 2016	16	5	7
Aug 2016	5	1	6
Sep 2016	12	5	16
Oct 2016	10	7	10
Nov 2016	3	13	27
Dec 2016	1	12	16
Total 2016	160	91	185
Jan 2017	1	10	0
Feb 2017	1	9	2
Mar 2017	2	19	8
Apr 2017	0	3	26
May 2017	0	27	21
Jun 2017	2	4	7
Jul 2017	1	12	5
Aug 2017	1	10	1
Sep 2017	1	7	3
Oct 2017	2	11	2
Nov 2017	2	10	3
Dec 2017	0	5	1
Total 2017	13	127	79
Jan 2018	1	8	2
Feb 2018	4	4	2
Mar 2018	0	8	6
Apr 2018	1	11	7
May 2018	0	18	7
Jun 2018	0	20	1
Jul 2018	1	10	6
Aug 2018	0	28	3
Sep 2018	1	26	3
Oct 2018	0	46	4
Nov 2018	1	46	6
Dec 2018	0	33	3
Total 2018	9	258	50
Jan 2019	2	21	3
Feb 2019	2	18	3
Mar 2019	3	9	6
Apr 2019	1	19	10
May 2019	2	11	6
Jun 2019	5	11	9
Jul 2019	3	11	12
Aug 2019	0	20	7
Sep 2019	2	25	4
Oct 2019	3	91	7
Nov 2019	4	17	13
Dec 2019	3	15	2
Total 2019	30	268	82
Jan 2020	1	14	3
Feb 2020	0	112	8
Mar 2020	0	104	1
Apr 2020	1	42	5
May 2020	1	26	3
Jun 2020	3	7	0
Jul 2020	1	8	3
Aug 2020	0	8	5
Sep 2020	0	19	5
Oct 2020	5	21	15
Nov 2020	2	22	7
Dec 2020	4	24	4
Total 2020	18	407	59
Jan 2021	1	17	2
Total 2021	1	17	2
Total	2044	3478	2596