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Articles

Transcranial Magnetic Stimulation during Positron Emission Tomography: A New Method for Studying Connectivity of the Human Cerebral Cortex

Tomáš Paus, Robert Jech, Christopher J. Thompson, Roch Comeau, Terry Peters and Alan C. Evans
Journal of Neuroscience 1 May 1997, 17 (9) 3178-3184; DOI: https://doi.org/10.1523/JNEUROSCI.17-09-03178.1997
Tomáš Paus
1Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4, and
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Robert Jech
2Department of Neurology, First Medical Faculty, Charles University, Prague, Czech Republic
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Christopher J. Thompson
1Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4, and
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Roch Comeau
1Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4, and
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Terry Peters
1Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4, and
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Alan C. Evans
1Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4, and
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    Fig. 1.

    The top of the figure shows a coronal (left) and a sagittal (right) section through a transmission scan obtained in one subject, superimposed on an MR image of the same subject. The TMS coil can be seen in the inset. Note the figure-eight shape of the coil. The bottom of the figure contains three-dimensional plots of the crystal identification matrix obtained in the absence of magnetic field (A), during magnetic stimulation (B), and during the same magnetic stimulation but with metal shields placed between the coil and the photo multipliers (C). Note a serious distortion of the matrix during unshielded exposure to the pulse magnetic field (B).

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    Fig. 2.

    The top of the figure shows the process of registering the subject’s head with the corresponding MR image. A computer-linked probe is touching the bridge of the nose (right); the matching location is highlighted by a cross hair on the MR image (left). The bottomof the figure shows a location targeted by TMS in this study, i.e., the left frontal eye field, FEF (left), and the probe–coil interface used to position the coil over this location (right). 1, Arm of the frameless-stereotaxy unit; 2, probe inside the interface; 3, coil inside the interface.

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    Fig. 3.

    Brain regions that showed significant (t > 3.5) correlations between CBF and the number of TMS pulse trains. The top of the figure shows a significant correlation in the vicinity of the frontal eye field (FEF), i.e., in the stimulated area. Thebottom of the figure shows one of the cortical regions that most likely was activated through the spread of electrical stimulation from the FEF, namely the parieto-occipital (PO) cortex of the ipsilateral hemisphere. A similar region is known to be connected anatomically with the FEF in the monkey (Schall et al., 1995).

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    Table 1.

    Brain regions with significant positive covariations between normalized CBF and the number of TMS pulse-trains

    REGION X YZt
    Left FEF−206474.3
    Left cuneus (PO)−12−80305.0
    Left superior parietal−36−61654.2
    Right superior parietal21−69503.6
    Right SEF8−5544.3
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The Journal of Neuroscience: 17 (9)
Journal of Neuroscience
Vol. 17, Issue 9
1 May 1997
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Transcranial Magnetic Stimulation during Positron Emission Tomography: A New Method for Studying Connectivity of the Human Cerebral Cortex
Tomáš Paus, Robert Jech, Christopher J. Thompson, Roch Comeau, Terry Peters, Alan C. Evans
Journal of Neuroscience 1 May 1997, 17 (9) 3178-3184; DOI: 10.1523/JNEUROSCI.17-09-03178.1997

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Transcranial Magnetic Stimulation during Positron Emission Tomography: A New Method for Studying Connectivity of the Human Cerebral Cortex
Tomáš Paus, Robert Jech, Christopher J. Thompson, Roch Comeau, Terry Peters, Alan C. Evans
Journal of Neuroscience 1 May 1997, 17 (9) 3178-3184; DOI: 10.1523/JNEUROSCI.17-09-03178.1997
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Keywords

  • TMS
  • PET
  • FEF
  • CBF
  • saccades
  • connectivity
  • visual cortex

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