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ARTICLE

Motoneuron Apoptosis Is Blocked by CEP-1347 (KT 7515), a Novel Inhibitor of the JNK Signaling Pathway

Anna C. Maroney, Marcie A. Glicksman, Alie N. Basma, Kevin M. Walton, Ernest Knight Jr, Carol A. Murphy, Becky A. Bartlett, James P. Finn, Thelma Angeles, Yuzuru Matsuda, Nicola T. Neff and Craig A. Dionne
Journal of Neuroscience 1 January 1998, 18 (1) 104-111; DOI: https://doi.org/10.1523/JNEUROSCI.18-01-00104.1998
Anna C. Maroney
1Cephalon Incorporated, West Chester, Pennsylvania 19380, and
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Marcie A. Glicksman
1Cephalon Incorporated, West Chester, Pennsylvania 19380, and
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Alie N. Basma
1Cephalon Incorporated, West Chester, Pennsylvania 19380, and
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Kevin M. Walton
1Cephalon Incorporated, West Chester, Pennsylvania 19380, and
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Ernest Knight Jr
1Cephalon Incorporated, West Chester, Pennsylvania 19380, and
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Carol A. Murphy
1Cephalon Incorporated, West Chester, Pennsylvania 19380, and
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Becky A. Bartlett
1Cephalon Incorporated, West Chester, Pennsylvania 19380, and
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James P. Finn
1Cephalon Incorporated, West Chester, Pennsylvania 19380, and
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Thelma Angeles
1Cephalon Incorporated, West Chester, Pennsylvania 19380, and
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Yuzuru Matsuda
2Kyowa-Hakko Kogyo Company, Limited, Machida-shi, Tokyo 194, Japan
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Nicola T. Neff
1Cephalon Incorporated, West Chester, Pennsylvania 19380, and
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Craig A. Dionne
1Cephalon Incorporated, West Chester, Pennsylvania 19380, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.18-01-00104.1998
PubMed 
9412490
Published By 
Society for Neuroscience
History 
  • Received June 11, 1997
  • Revision received October 6, 1997
  • Accepted October 15, 1997
  • First published January 1, 1998.
  • Version of record published January 1, 1998.
Copyright & Usage 
Copyright © 1998 Society for Neuroscience

Author Information

  1. Anna C. Maroney1,
  2. Marcie A. Glicksman1,
  3. Alie N. Basma1,
  4. Kevin M. Walton1,
  5. Ernest Knight Jr1,
  6. Carol A. Murphy1,
  7. Becky A. Bartlett1,
  8. James P. Finn1,
  9. Thelma Angeles1,
  10. Yuzuru Matsuda2,
  11. Nicola T. Neff1, and
  12. Craig A. Dionne1
  1. 1Cephalon Incorporated, West Chester, Pennsylvania 19380, and
  2. 2Kyowa-Hakko Kogyo Company, Limited, Machida-shi, Tokyo 194, Japan
View Full Text

Author contributions

View Abstract

Disclosures

    • Received June 11, 1997.
    • Revision received October 6, 1997.
    • Accepted October 15, 1997.
  • We thank J. Silvio Gutkind for providing the MEKK and JNK vectors, Anne Camoratto for helpful review of this manuscript, and Judy Richardson for manuscript preparation.

    Correspondence should be addressed to Dr. Anna Coco Maroney, Cephalon Incorporated, 145 Brandywine Parkway, West Chester, PA 19380.

    Dr. Glicksman’s present address: DuPont Merck, Experimental Station, Route 141 and Henry Clay Road, Wilmington, DE 19880.

    Dr. Murphy’s present address: Institute of Toxicology, Schorenstrasse 16, Schwerzenbach CH-8603, Switzerland.

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AbstractFullPdf
Jan 19999168
Feb 1999104031
Mar 199953322
Dec 199992931
Total 19993311892
Jan 2000125860
Feb 2000115949
Mar 2000144235
Apr 200044630
May 200054232
Jun 200053336
Jul 200052716
Aug 200053533
Sep 2000134150
Oct 200065555
Nov 200083933
Dec 200083931
Total 200096516460
Jan 2001155133
Feb 200134935
Mar 200154529
Apr 200153732
May 200184935
Jun 200135252
Jul 200164937
Aug 200143825
Sep 200174528
Oct 200175540
Nov 200143328
Dec 200132515
Total 200170528389
Jan 200243720
Feb 200263130
Mar 2002103021
Apr 200251215
May 200241618
Jun 200261416
Jul 200222023
Aug 200233228
Sep 200223634
Oct 200262423
Nov 200242019
Dec 200211820
Total 200253290267
Jan 200344134
Feb 200393011
Mar 200312918
Apr 200371211
May 200363019
Jun 200371913
Jul 2003132617
Aug 2003153518
Sep 2003102817
Oct 2003213913
Nov 2003332813
Dec 2003204711
Total 2003146364195
Jan 2004223114
Feb 2004153410
Mar 2004265027
Apr 2004172315
May 2004162710
Jun 2004173514
Jul 2004213817
Aug 2004153715
Sep 2004163718
Oct 2004113016
Nov 200416318
Dec 2004252912
Total 2004217402176
Jan 2005164114
Feb 2005204513
Mar 2005283114
Apr 200593015
May 2005123516
Jun 2005142613
Jul 20055268
Aug 200513217
Sep 2005133022
Oct 200574018
Nov 2005103622
Dec 200572612
Total 2005154387174
Jan 20065419
Feb 2006103913
Mar 200664513
Apr 200682710
May 2006142111
Jun 2006131210
Jul 200651711
Aug 200612149
Sep 2006114013
Oct 2006141714
Nov 200692417
Dec 2006102118
Total 2006117318148
Jan 2007103513
Feb 200752114
Mar 200782112
Apr 20074248
May 20076128
Jun 2007122416
Jul 20073204
Aug 200713105
Sep 20074138
Oct 200781718
Nov 20078167
Dec 20077124
Total 200788225117
Jan 200841519
Feb 2008121916
Mar 200814155
Apr 200892112
May 200811712
Jun 200817137
Jul 200892118
Aug 200831116
Sep 2008291411
Oct 200824149
Nov 200881611
Dec 200812812
Total 2008152174148
Jan 2009121613
Feb 200910158
Mar 2009151613
Apr 200961212
May 2009101312
Jun 20095135
Jul 2009181816
Aug 2009121815
Sep 200912811
Oct 200911128
Nov 200910812
Dec 200919812
Total 2009140157137
Jan 2010141316
Feb 20101499
Mar 20102158
Apr 20101055
May 2010898
Jun 20101094
Jul 2010654
Aug 2010452
Sep 2010554
Oct 201010139
Nov 2010122213
Dec 20101497
Total 201012810989
Jan 20111099
Feb 2011141110
Mar 20111666
Apr 2011141314
May 201111811
Jun 201121810
Jul 201117716
Aug 201111715
Sep 2011171510
Oct 2011162020
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Total 2011176118142
Jan 2012161310
Feb 2012101810
Mar 2012181723
Apr 2012101813
May 201217410
Jun 2012151317
Jul 201224715
Aug 201217519
Sep 20123310
Oct 2012101014
Nov 201222924
Dec 201234413
Total 2012196121178
Jan 201318811
Feb 20132467
Mar 201318919
Apr 201312421
May 2013231624
Jun 2013191026
Jul 201312411
Aug 2013151711
Sep 201371315
Oct 201381224
Nov 201315924
Dec 20137214
Total 2013178110207
Jan 20145420
Feb 20148919
Mar 2014131018
Apr 201411826
May 20149735
Jun 20148531
Jul 201419916
Aug 2014226
Sep 2014616
Oct 2014478
Nov 20145616
Dec 20148933
Total 20149877234
Jan 201581637
Feb 20155913
Mar 2015378
Apr 201510512
May 2015111418
Jun 20152786
Jul 201548105
Aug 2015177210
Sep 2015135210
Oct 20159219
Nov 201591115
Dec 20154314
Total 2015164209167
Jan 20162810
Feb 201613218
Mar 2016181211
Apr 20166913
May 20161195
Jun 20166520
Jul 2016168
Aug 2016131320
Sep 2016141913
Oct 2016534
Nov 20163136
Dec 20166116
Total 201698110134
Jan 2017282
Feb 2017053
Mar 20172239
Apr 20172116
May 20172484
Jun 2017293
Jul 20173135
Aug 2017343
Sep 20170134
Oct 20171235
Nov 20171195
Dec 2017161
Total 20171918250
Jan 2018386
Feb 20180143
Mar 20180186
Apr 20182154
May 20182205
Jun 20180222
Jul 20181145
Aug 20182183
Sep 20181192
Oct 20181212
Nov 20183127
Dec 20182197
Total 20181720052
Jan 20193146
Feb 20195168
Mar 2019383
Apr 201931315
May 20197177
Jun 20192910
Jul 2019397
Aug 201931311
Sep 20192655
Oct 201921808
Nov 20190309
Dec 20192126
Total 20193538695
Jan 20202214
Feb 20201119
Mar 2020296
Apr 2020681
May 2020386
Jun 20200114
Jul 20200125
Aug 2020374
Sep 20201204
Oct 20203293
Nov 20205174
Dec 20206205
Total 20203217355
Jan 20211185
Total 20211185
Total240852923711
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The Journal of Neuroscience: 18 (1)
Journal of Neuroscience
Vol. 18, Issue 1
1 Jan 1998
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Motoneuron Apoptosis Is Blocked by CEP-1347 (KT 7515), a Novel Inhibitor of the JNK Signaling Pathway
Anna C. Maroney, Marcie A. Glicksman, Alie N. Basma, Kevin M. Walton, Ernest Knight, Carol A. Murphy, Becky A. Bartlett, James P. Finn, Thelma Angeles, Yuzuru Matsuda, Nicola T. Neff, Craig A. Dionne
Journal of Neuroscience 1 January 1998, 18 (1) 104-111; DOI: 10.1523/JNEUROSCI.18-01-00104.1998

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Motoneuron Apoptosis Is Blocked by CEP-1347 (KT 7515), a Novel Inhibitor of the JNK Signaling Pathway
Anna C. Maroney, Marcie A. Glicksman, Alie N. Basma, Kevin M. Walton, Ernest Knight, Carol A. Murphy, Becky A. Bartlett, James P. Finn, Thelma Angeles, Yuzuru Matsuda, Nicola T. Neff, Craig A. Dionne
Journal of Neuroscience 1 January 1998, 18 (1) 104-111; DOI: 10.1523/JNEUROSCI.18-01-00104.1998
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Keywords

  • motoneurons
  • indolocarbazole
  • CEP-1347
  • survival
  • apoptosis
  • c-jun N-terminal kinase
  • mitogen-activated protein kinase
  • p38

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