Upregulation of Pleiotrophin Gene Expression in Developing Microvasculature, Macrophages, and Astrocytes after Acute Ischemic Brain Injury

Hsiu-Jeng Yeh; Yong Y. He; Jan Xu; Chung Y. Hsu; Thomas F. Deuel

doi:10.1523/JNEUROSCI.18-10-03699.1998

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.18-10-03699.1998

PubMed

9570800

Published By

Society for Neuroscience

History

Received December 30, 1997
Revision received February 25, 1998
Accepted March 4, 1998
First published May 15, 1998.

Version of record published May 15, 1998.

Author Information

Hsiu-Jeng Yeh1,
Yong Y. He2,
Jan Xu2,
Chung Y. Hsu2, and
Thomas F. Deuel1

¹Department of Medicine, Division of Growth Regulation, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, and
²Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63310

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Author contributions

Disclosures

Received December 30, 1997.
Revision received February 25, 1998.
Accepted March 4, 1998.

This work was supported in part by Office of Naval Research Grant N00014-95-1-0582, National Institute of Neurological Diseases and Stroke Grants NS25545, NS28995, and NS32636, and National Institutes of Health Grants HL31102, CA66029, and CA49712 (T.F.D.).
Correspondence should be addressed to Thomas F. Deuel, Department of Medicine, Division of Growth Regulation, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215.

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	Abstract	Full	Pdf
Jan 1999	2	2	2
Feb 1999	5	3	3
Mar 1999	0	12	12
Dec 1999	1	5	4
Total 1999	8	22	21
Jan 2000	4	12	7
Feb 2000	0	15	8
Mar 2000	2	2	6
Apr 2000	3	13	5
May 2000	2	11	7
Jun 2000	3	8	9
Jul 2000	0	7	4
Aug 2000	1	11	5
Sep 2000	0	8	11
Oct 2000	4	14	5
Nov 2000	2	14	10
Dec 2000	4	13	28
Total 2000	25	128	105
Jan 2001	2	12	7
Feb 2001	3	13	10
Mar 2001	3	17	8
Apr 2001	2	25	16
May 2001	5	19	15
Jun 2001	1	7	6
Jul 2001	0	9	11
Aug 2001	1	9	11
Sep 2001	2	15	15
Oct 2001	3	13	10
Nov 2001	0	10	0
Dec 2001	0	10	6
Total 2001	22	159	115
Jan 2002	3	14	19
Feb 2002	1	11	7
Mar 2002	3	9	13
Apr 2002	0	19	19
May 2002	1	7	11
Jun 2002	1	20	12
Jul 2002	2	7	8
Aug 2002	0	11	19
Sep 2002	0	5	6
Oct 2002	2	8	30
Nov 2002	2	6	38
Dec 2002	0	6	36
Total 2002	15	123	218
Jan 2003	2	11	22
Feb 2003	1	4	7
Mar 2003	4	9	14
Apr 2003	2	15	15
May 2003	1	9	6
Jun 2003	0	8	6
Jul 2003	5	24	24
Aug 2003	7	14	10
Sep 2003	9	25	14
Oct 2003	14	36	23
Nov 2003	16	42	17
Dec 2003	13	22	12
Total 2003	74	219	170
Jan 2004	13	34	12
Feb 2004	9	20	15
Mar 2004	16	33	16
Apr 2004	22	23	14
May 2004	12	24	8
Jun 2004	23	18	13
Jul 2004	10	18	7
Aug 2004	26	19	11
Sep 2004	17	13	9
Oct 2004	11	24	11
Nov 2004	6	19	9
Dec 2004	13	20	14
Total 2004	178	265	139
Jan 2005	15	26	4
Feb 2005	12	21	21
Mar 2005	12	19	9
Apr 2005	7	13	1
May 2005	5	22	12
Jun 2005	4	17	5
Jul 2005	8	18	13
Aug 2005	7	14	12
Sep 2005	3	10	7
Oct 2005	6	19	18
Nov 2005	9	11	3
Dec 2005	3	25	13
Total 2005	91	215	118
Jan 2006	5	13	2
Feb 2006	2	11	12
Mar 2006	3	8	3
Apr 2006	8	19	6
May 2006	6	5	7
Jun 2006	4	5	3
Jul 2006	2	12	7
Aug 2006	6	20	6
Sep 2006	8	17	11
Oct 2006	5	19	16
Nov 2006	6	11	6
Dec 2006	6	10	11
Total 2006	61	150	90
Jan 2007	4	19	13
Feb 2007	2	15	13
Mar 2007	2	29	16
Apr 2007	10	12	9
May 2007	2	10	11
Jun 2007	1	11	5
Jul 2007	6	4	4
Aug 2007	8	12	3
Sep 2007	3	5	4
Oct 2007	6	2	4
Nov 2007	2	7	2
Dec 2007	3	2	4
Total 2007	49	128	88
Jan 2008	5	7	3
Feb 2008	4	9	3
Mar 2008	10	9	16
Apr 2008	5	7	9
May 2008	3	7	10
Jun 2008	7	6	6
Jul 2008	4	3	7
Aug 2008	11	7	7
Sep 2008	12	14	17
Oct 2008	12	9	10
Nov 2008	5	5	2
Dec 2008	2	7	5
Total 2008	80	90	95
Jan 2009	3	5	11
Feb 2009	2	5	8
Mar 2009	3	4	2
Apr 2009	3	5	4
May 2009	7	8	8
Jun 2009	8	37	12
Jul 2009	6	2	3
Aug 2009	7	3	8
Sep 2009	6	5	4
Oct 2009	7	4	8
Nov 2009	8	7	13
Dec 2009	13	6	6
Total 2009	73	91	87
Jan 2010	6	13	13
Feb 2010	6	6	1
Mar 2010	11	6	0
Apr 2010	2	11	13
May 2010	5	6	11
Jun 2010	5	10	102
Jul 2010	1	12	11
Aug 2010	2	4	5
Sep 2010	10	9	5
Oct 2010	7	12	10
Nov 2010	6	14	8
Dec 2010	7	4	8
Total 2010	68	107	187
Jan 2011	10	10	12
Feb 2011	10	12	11
Mar 2011	6	6	9
Apr 2011	10	5	10
May 2011	9	5	12
Jun 2011	9	9	10
Jul 2011	8	5	9
Aug 2011	6	8	17
Sep 2011	8	6	9
Oct 2011	11	13	14
Nov 2011	7	6	20
Dec 2011	4	4	8
Total 2011	98	89	141
Jan 2012	6	19	19
Feb 2012	0	3	7
Mar 2012	11	7	5
Apr 2012	3	10	7
May 2012	14	2	2
Jun 2012	12	2	8
Jul 2012	1	1	12
Aug 2012	5	6	9
Sep 2012	8	1	2
Oct 2012	6	4	11
Nov 2012	18	4	7
Dec 2012	26	5	6
Total 2012	110	64	95
Jan 2013	12	4	6
Feb 2013	20	2	5
Mar 2013	15	6	8
Apr 2013	13	6	6
May 2013	12	4	6
Jun 2013	5	11	10
Jul 2013	5	4	6
Aug 2013	6	5	6
Sep 2013	19	1	2
Oct 2013	5	1	4
Nov 2013	6	1	2
Dec 2013	8	0	5
Total 2013	126	45	66
Jan 2014	7	7	8
Feb 2014	6	2	1
Mar 2014	1	3	11
Apr 2014	15	4	9
May 2014	6	5	36
Jun 2014	6	8	9
Jul 2014	8	8	4
Aug 2014	5	4	8
Sep 2014	5	5	8
Oct 2014	6	5	4
Nov 2014	6	5	3
Dec 2014	1	5	4
Total 2014	72	61	105
Jan 2015	3	9	5
Feb 2015	3	3	8
Mar 2015	4	7	2
Apr 2015	4	7	3
May 2015	3	8	7
Jun 2015	8	16	6
Jul 2015	6	7	7
Aug 2015	4	6	7
Sep 2015	3	6	6
Oct 2015	7	5	2
Nov 2015	3	11	1
Dec 2015	7	7	5
Total 2015	55	92	59
Jan 2016	0	9	11
Feb 2016	3	5	5
Mar 2016	7	11	11
Apr 2016	3	13	7
May 2016	9	3	4
Jun 2016	10	10	4
Jul 2016	2	6	11
Aug 2016	35	6	5
Sep 2016	62	5	7
Oct 2016	27	14	7
Nov 2016	32	3	6
Dec 2016	10	27	8
Total 2016	200	112	86
Jan 2017	4	43	5
Feb 2017	0	26	3
Mar 2017	2	67	8
Apr 2017	4	39	11
May 2017	51	25	7
Jun 2017	142	9	9
Jul 2017	37	18	3
Aug 2017	15	8	3
Sep 2017	3	9	8
Oct 2017	3	19	8
Nov 2017	0	19	8
Dec 2017	3	8	2
Total 2017	264	290	75
Jan 2018	5	7	5
Feb 2018	3	9	3
Mar 2018	6	21	11
Apr 2018	5	20	13
May 2018	1	12	3
Jun 2018	0	14	1
Jul 2018	1	12	5
Aug 2018	1	30	7
Sep 2018	1	35	3
Oct 2018	1	41	3
Nov 2018	1	44	3
Dec 2018	0	16	2
Total 2018	25	261	59
Jan 2019	1	15	3
Feb 2019	2	14	4
Mar 2019	2	10	5
Apr 2019	3	8	8
May 2019	6	18	9
Jun 2019	3	14	7
Jul 2019	3	7	12
Aug 2019	1	9	12
Sep 2019	1	7	3
Oct 2019	5	11	15
Nov 2019	8	16	9
Dec 2019	3	7	4
Total 2019	38	136	91
Jan 2020	6	13	8
Feb 2020	2	8	3
Mar 2020	4	6	6
Apr 2020	13	8	16
May 2020	7	12	6
Jun 2020	0	4	4
Jul 2020	2	12	3
Aug 2020	2	10	5
Sep 2020	1	18	13
Oct 2020	7	29	5
Nov 2020	7	11	5
Dec 2020	8	17	4
Total 2020	59	148	78
Jan 2021	8	19	9
Feb 2021	3	13	4
Mar 2021	3	15	12
Apr 2021	5	20	7
May 2021	6	18	10
Jun 2021	3	36	5
Jul 2021	5	9	15
Aug 2021	3	25	12
Sep 2021	1	23	10
Oct 2021	1	16	22
Nov 2021	2	11	20
Dec 2021	2	12	6
Total 2021	42	217	132
Jan 2022	3	31	5
Feb 2022	5	12	3
Mar 2022	1	24	7
Apr 2022	2	31	2
May 2022	4	14	14
Total 2022	15	112	31
Total	1848	3324	2451