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ARTICLE

On the Action of the Anti-Absence Drug Ethosuximide in the Rat and Cat Thalamus

Nathalie Leresche, H. Rheinallt Parri, Gül Erdemli, Alice Guyon, Jonathan P. Turner, Stephen R. Williams, Eftihia Asprodini and Vincenzo Crunelli
Journal of Neuroscience 1 July 1998, 18 (13) 4842-4853; DOI: https://doi.org/10.1523/JNEUROSCI.18-13-04842.1998
Nathalie Leresche
2Institut des Neurosciences, Centre National de la Recherche Scientifique, UMR 7624 Université Pierre et Marie Curie, Paris, France
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H. Rheinallt Parri
1Physiology Unit, School of Molecular and Medical Biosciences, University of Wales Cardiff, Cardiff CF1 1SS, United Kingdom, and
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Gül Erdemli
1Physiology Unit, School of Molecular and Medical Biosciences, University of Wales Cardiff, Cardiff CF1 1SS, United Kingdom, and
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Alice Guyon
2Institut des Neurosciences, Centre National de la Recherche Scientifique, UMR 7624 Université Pierre et Marie Curie, Paris, France
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Jonathan P. Turner
1Physiology Unit, School of Molecular and Medical Biosciences, University of Wales Cardiff, Cardiff CF1 1SS, United Kingdom, and
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Stephen R. Williams
1Physiology Unit, School of Molecular and Medical Biosciences, University of Wales Cardiff, Cardiff CF1 1SS, United Kingdom, and
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Eftihia Asprodini
1Physiology Unit, School of Molecular and Medical Biosciences, University of Wales Cardiff, Cardiff CF1 1SS, United Kingdom, and
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Vincenzo Crunelli
1Physiology Unit, School of Molecular and Medical Biosciences, University of Wales Cardiff, Cardiff CF1 1SS, United Kingdom, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.18-13-04842.1998
PubMed 
9634550
Published By 
Society for Neuroscience
History 
  • Received December 29, 1997
  • Revision received April 10, 1998
  • Accepted April 16, 1998
  • First published July 1, 1998.
  • Version of record published July 1, 1998.
Copyright & Usage 
Copyright © 1998 Society for Neuroscience

Author Information

  1. Nathalie Leresche2,
  2. H. Rheinallt Parri1,
  3. Gül Erdemli1,
  4. Alice Guyon2,
  5. Jonathan P. Turner1,
  6. Stephen R. Williams1,
  7. Eftihia Asprodini1, and
  8. Vincenzo Crunelli1
  1. 1Physiology Unit, School of Molecular and Medical Biosciences, University of Wales Cardiff, Cardiff CF1 1SS, United Kingdom, and
  2. 2Institut des Neurosciences, Centre National de la Recherche Scientifique, UMR 7624 Université Pierre et Marie Curie, Paris, France
View Full Text

Author contributions

Disclosures

    • Received December 29, 1997.
    • Revision received April 10, 1998.
    • Accepted April 16, 1998.
  • This work was supported by the Wellcome Trust (Grant 37089), the Centre National de la Recherche Scientifique (Unité de Recherche Associée 1488), the European Union (Biomed 2, Grant 97-2093), and the British Council (Alliance). S.R.W. was a Wellcome Prize Student. We thank Professor D. Paupardin-Tritsch for comments on this manuscript, Professor C. Marescaux for providing the GAERS rats, Mr. T. M. Gould for technical assistance, and Mr. R. A. Jones for photography.

    Correspondence should be addressed to Dr. Vincenzo Crunelli, Physiology Unit, School of Molecular and Medical Biosciences, University of Wales Cardiff, Museum Avenue, Cardiff CF1 1SS, UK.

    Dr. Asprodini’s present address: Department of Pharmacology, University of Thessaly, Larisa, Greece.

    Dr. Turner’s present address: Department of Visual Science, Institute of Ophthalmology, London EC1V, UK.

    Dr. Williams’ present address: Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia.

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Jan 1999121
Feb 1999402
Mar 1999372
Dec 1999275
Total 1999101610
Jan 2000174
Feb 2000275
Mar 2000243
Apr 2000582
May 2000163
Jun 2000064
Jul 2000054
Aug 20001108
Sep 20002136
Oct 20005117
Nov 2000166
Dec 20005127
Total 2000259559
Jan 20011206
Feb 20014126
Mar 20014104
Apr 200142110
May 20014107
Jun 200111110
Jul 20013126
Aug 200121710
Sep 2001069
Oct 20012157
Nov 200132417
Dec 2001185
Total 20012916697
Jan 20024118
Feb 20023134
Mar 200222415
Apr 20021109
May 20020128
Jun 20021910
Jul 200212320
Aug 2002075
Sep 200221418
Oct 2002495
Nov 2002055
Dec 2002034
Total 200218140111
Jan 2003149
Feb 2003271
Mar 2003188
Apr 200311718
May 20032106
Jun 20034126
Jul 200382315
Aug 20038247
Sep 2003102716
Oct 200391622
Nov 2003142312
Dec 200314195
Total 200374190125
Jan 2004141910
Feb 200412169
Mar 200413169
Apr 2004231413
May 2004141910
Jun 200484112
Jul 200415276
Aug 200438252
Sep 200419128
Oct 20046134
Nov 20048165
Dec 200417187
Total 200418723695
Jan 2005212411
Feb 200513309
Mar 2005202212
Apr 200582312
May 20053145
Jun 2005103910
Jul 20056187
Aug 20058121
Sep 20054143
Oct 20058163
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Total 200511524378
Jan 20068197
Feb 20063174
Mar 20060146
Apr 2006694
May 200661717
Jun 200642215
Jul 2006398
Aug 20064144
Sep 20062165
Oct 200611217
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Total 20065918883
Jan 20074219
Feb 200721810
Mar 20075957
Apr 200713122
May 200753310
Jun 20077823
Jul 20074185
Aug 20076178
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Oct 20072175
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Dec 20079129
Total 20076536186
Jan 20082165
Feb 20084224
Mar 20087197
Apr 20084255
May 200812165
Jun 20089197
Jul 200852414
Aug 20084168
Sep 200818123
Oct 20088117
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Total 20088720175
Jan 20098138
Feb 20095105
Mar 2009483
Apr 20091245
May 2009083
Jun 200901610
Jul 20096143
Aug 2009102411
Sep 20097174
Oct 20096168
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Total 20095918782
Jan 20103135
Feb 20102183
Mar 20108186
Apr 20100141
May 201063913
Jun 20103152
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Aug 20102226
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Total 20105923276
Jan 20114156
Feb 20113185
Mar 201111146
Apr 20116167
May 20117147
Jun 201111167
Jul 20115199
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Sep 201110279
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Apr 201272318
May 20121179
Jun 201210169
Jul 2012957
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Total 2012104147123
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Feb 201311118
Mar 2013111516
Apr 201361210
May 2013358
Jun 2013245
Jul 20136810
Aug 2013534
Sep 20135910
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Feb 20142663
Mar 201451116
Apr 201431210
May 2014161914
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Jul 201412159
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Sep 2014288
Oct 2014765
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Dec 2014324647
Total 2014103213196
Jan 2015282322
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Mar 20156207
Apr 20159118
May 20157165
Jun 2015376
Jul 20154109
Aug 20158125
Sep 2015111612
Oct 201514165
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Dec 201513143
Total 2015114431101
Jan 201610190
Feb 20167185
Mar 2016141713
Apr 201614227
May 201610257
Jun 2016915815
Jul 2016773
Aug 2016974
Sep 2016798
Oct 201692512
Nov 201652210
Dec 20160429
Total 201610137193
Jan 20170307
Feb 201704210
Mar 201712914
Apr 20171148
May 201723315
Jun 201751810
Jul 201701811
Aug 20170145
Sep 20172236
Oct 20171223
Nov 20170184
Dec 20173354
Total 20171529697
Jan 20181163
Feb 20183286
Mar 201862417
Apr 201822010
May 20180255
Jun 20180294
Jul 20180215
Aug 20182203
Sep 20183204
Oct 20180213
Nov 20182131
Dec 2018074
Total 20181924465
Jan 20193187
Feb 20193154
Mar 201912610
Apr 20192226
May 20192134
Jun 2019196
Jul 20191156
Aug 201912513
Sep 20190184
Oct 20191227
Nov 20190187
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Total 20192121178
Jan 20203262
Feb 20200143
Mar 20200325
Apr 20203224
May 20206266
Jun 202001037
Jul 20200240
Aug 20203102
Sep 20201174
Oct 202054512
Nov 202072911
Dec 20206275
Total 20203437561
Jan 202143615
Feb 202112411
Mar 202162920
Apr 20216318
May 2021104220
Jun 202163112
Jul 202161711
Aug 20211316
Sep 20212253
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Total 202153335152
Jan 20225276
Feb 20224328
Mar 20220244
Apr 202243310
May 20226217
Total 20221913735
Total153253502190
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The Journal of Neuroscience: 18 (13)
Journal of Neuroscience
Vol. 18, Issue 13
1 Jul 1998
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On the Action of the Anti-Absence Drug Ethosuximide in the Rat and Cat Thalamus
Nathalie Leresche, H. Rheinallt Parri, Gül Erdemli, Alice Guyon, Jonathan P. Turner, Stephen R. Williams, Eftihia Asprodini, Vincenzo Crunelli
Journal of Neuroscience 1 July 1998, 18 (13) 4842-4853; DOI: 10.1523/JNEUROSCI.18-13-04842.1998

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On the Action of the Anti-Absence Drug Ethosuximide in the Rat and Cat Thalamus
Nathalie Leresche, H. Rheinallt Parri, Gül Erdemli, Alice Guyon, Jonathan P. Turner, Stephen R. Williams, Eftihia Asprodini, Vincenzo Crunelli
Journal of Neuroscience 1 July 1998, 18 (13) 4842-4853; DOI: 10.1523/JNEUROSCI.18-13-04842.1998
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Keywords

  • ethosuximide
  • thalamus
  • Na+currents
  • K+ currents
  • Ca2+currents
  • tonic firing
  • burst firing
  • absence epilepsy

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