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ARTICLE

Neurturin Exerts Potent Actions on Survival and Function of Midbrain Dopaminergic Neurons

Brian A. Horger, Merry C. Nishimura, Mark P. Armanini, Li-Chong Wang, Kris T. Poulsen, Carl Rosenblad, Deniz Kirik, Barbara Moffat, Laura Simmons, Eugene Johnson Jr, Jeff Milbrandt, Arnon Rosenthal, Anders Bjorklund, Richard A. Vandlen, Mary A. Hynes and Heidi S. Phillips
Journal of Neuroscience 1 July 1998, 18 (13) 4929-4937; https://doi.org/10.1523/JNEUROSCI.18-13-04929.1998
Brian A. Horger
1Departments of
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Merry C. Nishimura
1Departments of
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Mark P. Armanini
1Departments of
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Li-Chong Wang
1Departments of
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Kris T. Poulsen
1Departments of
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Carl Rosenblad
6Pharmacology, Washington University MedicalSchool, St. Louis, Missouri 63110, and Wallenberg Neurocentrum Institute, Lund, Sweden
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Deniz Kirik
6Pharmacology, Washington University MedicalSchool, St. Louis, Missouri 63110, and Wallenberg Neurocentrum Institute, Lund, Sweden
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Barbara Moffat
2Neuroscience,
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Laura Simmons
3Protein Chemistry, and
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Eugene Johnson Jr
5Pathology and
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Jeff Milbrandt
4Molecular Biology, Genentech, South SanFrancisco, California 94080, Departments of
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Arnon Rosenthal
1Departments of
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Anders Bjorklund
6Pharmacology, Washington University MedicalSchool, St. Louis, Missouri 63110, and Wallenberg Neurocentrum Institute, Lund, Sweden
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Richard A. Vandlen
2Neuroscience,
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Mary A. Hynes
1Departments of
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Heidi S. Phillips
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.18-13-04929.1998
PubMed 
9634558
Published By 
Society for Neuroscience
History 
  • Received December 11, 1997
  • Revision received April 7, 1998
  • Accepted April 15, 1998
  • First published July 1, 1998.
  • Version of record published July 1, 1998.
Copyright & Usage 
Copyright © 1998 Society for Neuroscience

Author Information

  1. Brian A. Horger1,
  2. Merry C. Nishimura1,
  3. Mark P. Armanini1,
  4. Li-Chong Wang1,
  5. Kris T. Poulsen1,
  6. Carl Rosenblad6,
  7. Deniz Kirik6,
  8. Barbara Moffat2,
  9. Laura Simmons3,
  10. Eugene Johnson Jr5,
  11. Jeff Milbrandt4,
  12. Arnon Rosenthal1,
  13. Anders Bjorklund6,
  14. Richard A. Vandlen2,
  15. Mary A. Hynes1, and
  16. Heidi S. Phillips1
  1. 1Departments of
  2. 2Neuroscience,
  3. 3Protein Chemistry, and
  4. 4Molecular Biology, Genentech, South SanFrancisco, California 94080, Departments of
  5. 5Pathology and
  6. 6Pharmacology, Washington University MedicalSchool, St. Louis, Missouri 63110, and Wallenberg Neurocentrum Institute, Lund, Sweden
View Full Text

Author contributions

Disclosures

    • Received December 11, 1997.
    • Revision received April 7, 1998.
    • Accepted April 15, 1998.
  • This work was supported in part by National Institutes of Health Grants RO1AG13729 and RO1AG13730 and by Grant 04X-3874 from the Swedish Medical Research Council. We thank Wayne Anstine for preparation of figures, Evelyn Berry for manuscript preparation, and Brigitte Devaux for helpful suggestions and coordination of resources.

    B.H. and M.N. contributed equally to this manuscript.

    Correspondence should be addressed to Dr. Heidi Phillips, Genentech, Inc., One DNA Way, South San Francisco, CA 94080.

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The Journal of Neuroscience: 18 (13)
Journal of Neuroscience
Vol. 18, Issue 13
1 Jul 1998
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Neurturin Exerts Potent Actions on Survival and Function of Midbrain Dopaminergic Neurons
Brian A. Horger, Merry C. Nishimura, Mark P. Armanini, Li-Chong Wang, Kris T. Poulsen, Carl Rosenblad, Deniz Kirik, Barbara Moffat, Laura Simmons, Eugene Johnson Jr, Jeff Milbrandt, Arnon Rosenthal, Anders Bjorklund, Richard A. Vandlen, Mary A. Hynes, Heidi S. Phillips
Journal of Neuroscience 1 July 1998, 18 (13) 4929-4937; DOI: 10.1523/JNEUROSCI.18-13-04929.1998

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Neurturin Exerts Potent Actions on Survival and Function of Midbrain Dopaminergic Neurons
Brian A. Horger, Merry C. Nishimura, Mark P. Armanini, Li-Chong Wang, Kris T. Poulsen, Carl Rosenblad, Deniz Kirik, Barbara Moffat, Laura Simmons, Eugene Johnson Jr, Jeff Milbrandt, Arnon Rosenthal, Anders Bjorklund, Richard A. Vandlen, Mary A. Hynes, Heidi S. Phillips
Journal of Neuroscience 1 July 1998, 18 (13) 4929-4937; DOI: 10.1523/JNEUROSCI.18-13-04929.1998
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Keywords

  • neurturin
  • GDNF
  • dopaminergic
  • trophic
  • Parkinson’s
  • nigrostriatal
  • 6-OHDA

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