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ARTICLE

The Sodium Channel Scn8a Is the Major Contributor to the Postnatal Developmental Increase of Sodium Current Density in Spinal Motoneurons

Kelly D. Garcı́a, Leslie K. Sprunger, Miriam H. Meisler and Kurt G. Beam
Journal of Neuroscience 15 July 1998, 18 (14) 5234-5239; https://doi.org/10.1523/JNEUROSCI.18-14-05234.1998
Kelly D. Garcı́a
1Department of Anatomy and Neurobiology, Colorado State University, Fort Collins, Colorado 80523-1670, and
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Leslie K. Sprunger
2Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109-0618
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Miriam H. Meisler
2Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109-0618
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Kurt G. Beam
1Department of Anatomy and Neurobiology, Colorado State University, Fort Collins, Colorado 80523-1670, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.18-14-05234.1998
PubMed 
9651206
Published By 
Society for Neuroscience
History 
  • Received May 8, 1987
  • Revision received April 28, 1998
  • Accepted May 4, 1998
  • First published July 15, 1998.
  • Version of record published July 15, 1998.
Copyright & Usage 
Copyright © 1998 Society for Neuroscience

Author Information

  1. Kelly D. Garcı́a1,
  2. Leslie K. Sprunger2,
  3. Miriam H. Meisler2, and
  4. Kurt G. Beam1
  1. 1Department of Anatomy and Neurobiology, Colorado State University, Fort Collins, Colorado 80523-1670, and
  2. 2Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109-0618
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Author contributions

Disclosures

    • Received May 8, 1987.
    • Revision received April 28, 1998.
    • Accepted May 4, 1998.
  • This research was supported by National Institutes of Health Grants NS34509 (M.H.M.), HL02972 (L.K.S.), and NS24444 (K.G.B.) and a Muscular Dystrophy Association grant to Jesús Garcı́a. We thank Jesús Garcı́a for assistance in performing some of the measurements of sodium currents.

    Correspondence should be addressed to Kurt Beam, Department of Anatomy and Neurobiology, Colorado State University, Fort Collins, CO 80523-1670.

    Dr. Garcı́a’s present address: Department of Physiology and Biophysics, University of Illinois at Chicago, 900 South Ashland Avenue, Chicago, IL 60607.

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The Journal of Neuroscience: 18 (14)
Journal of Neuroscience
Vol. 18, Issue 14
15 Jul 1998
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The Sodium Channel Scn8a Is the Major Contributor to the Postnatal Developmental Increase of Sodium Current Density in Spinal Motoneurons
Kelly D. Garcı́a, Leslie K. Sprunger, Miriam H. Meisler, Kurt G. Beam
Journal of Neuroscience 15 July 1998, 18 (14) 5234-5239; DOI: 10.1523/JNEUROSCI.18-14-05234.1998

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The Sodium Channel Scn8a Is the Major Contributor to the Postnatal Developmental Increase of Sodium Current Density in Spinal Motoneurons
Kelly D. Garcı́a, Leslie K. Sprunger, Miriam H. Meisler, Kurt G. Beam
Journal of Neuroscience 15 July 1998, 18 (14) 5234-5239; DOI: 10.1523/JNEUROSCI.18-14-05234.1998
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Keywords

  • motoneurons
  • sodium channels
  • SCN8A
  • postnatal development
  • motor end plate disease
  • neuromuscular system
  • mouse

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