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ARTICLE

Transplanted Olfactory Ensheathing Cells Remyelinate and Enhance Axonal Conduction in the Demyelinated Dorsal Columns of the Rat Spinal Cord

Toshio Imaizumi, Karen L. Lankford, Stephen G. Waxman, Charles A. Greer and Jeffery D. Kocsis
Journal of Neuroscience 15 August 1998, 18 (16) 6176-6185; DOI: https://doi.org/10.1523/JNEUROSCI.18-16-06176.1998
Toshio Imaizumi
1Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510,
2PVA/EPVA Neuroscience Research Center, Veterans Affairs Medical Center, West Haven, Connecticut 06516, and
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Karen L. Lankford
1Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510,
2PVA/EPVA Neuroscience Research Center, Veterans Affairs Medical Center, West Haven, Connecticut 06516, and
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Stephen G. Waxman
1Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510,
2PVA/EPVA Neuroscience Research Center, Veterans Affairs Medical Center, West Haven, Connecticut 06516, and
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Charles A. Greer
3Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06510
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Jeffery D. Kocsis
1Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510,
2PVA/EPVA Neuroscience Research Center, Veterans Affairs Medical Center, West Haven, Connecticut 06516, and
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Abstract

Olfactory ensheathing cells (OECs), which have properties of both astrocytes and Schwann cells, can remyelinate axons with a Schwann cell-like pattern of myelin. In this study the pattern and extent of remyelination and the electrophysiological properties of dorsal column axons were characterized after transplantation of OECs into a demyelinated rat spinal cord lesion. Dorsal columns of adult rat spinal cords were demyelinated by x-ray irradiation and focal injections of ethidium bromide. Cell suspensions of acutely dissociated OECs from neonatal rats were injected into the lesion 6 d after x-ray irradiation. At 21–25 d after transplantation of OECs, the spinal cords were maintained in an in vitro recording chamber to study the conduction properties of the axons. The remyelinated axons displayed improved conduction velocity and frequency–response properties, and action potentials were conducted a greater distance into the lesion, suggesting that conduction block was overcome. Quantitative histological analysis revealed remyelinated axons near and remote from the cell injection site, indicating extensive migration of OECs within the lesion. These data support the conclusion that transplantation of neonatal OECs results in quantitatively extensive and functional remyelination of demyelinated dorsal column axons.

  • olfactory ensheathing cell
  • transplantation
  • demyelination
  • remyelination
  • dorsal column
  • spinal cord
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The Journal of Neuroscience: 18 (16)
Journal of Neuroscience
Vol. 18, Issue 16
15 Aug 1998
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Transplanted Olfactory Ensheathing Cells Remyelinate and Enhance Axonal Conduction in the Demyelinated Dorsal Columns of the Rat Spinal Cord
Toshio Imaizumi, Karen L. Lankford, Stephen G. Waxman, Charles A. Greer, Jeffery D. Kocsis
Journal of Neuroscience 15 August 1998, 18 (16) 6176-6185; DOI: 10.1523/JNEUROSCI.18-16-06176.1998

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Transplanted Olfactory Ensheathing Cells Remyelinate and Enhance Axonal Conduction in the Demyelinated Dorsal Columns of the Rat Spinal Cord
Toshio Imaizumi, Karen L. Lankford, Stephen G. Waxman, Charles A. Greer, Jeffery D. Kocsis
Journal of Neuroscience 15 August 1998, 18 (16) 6176-6185; DOI: 10.1523/JNEUROSCI.18-16-06176.1998
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Keywords

  • olfactory ensheathing cell
  • transplantation
  • demyelination
  • remyelination
  • dorsal column
  • spinal cord

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