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ARTICLE

Maturation-Dependent Vulnerability of Oligodendrocytes to Oxidative Stress-Induced Death Caused by Glutathione Depletion

Stephen A. Back, Xiaodong Gan, Ya Li, Paul A. Rosenberg and Joseph J. Volpe
Journal of Neuroscience 15 August 1998, 18 (16) 6241-6253; DOI: https://doi.org/10.1523/JNEUROSCI.18-16-06241.1998
Stephen A. Back
1Department of Neurology, Children’s Hospital and Harvard Medical School, Boston, Massachusetts 02115
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Xiaodong Gan
1Department of Neurology, Children’s Hospital and Harvard Medical School, Boston, Massachusetts 02115
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Ya Li
1Department of Neurology, Children’s Hospital and Harvard Medical School, Boston, Massachusetts 02115
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Paul A. Rosenberg
1Department of Neurology, Children’s Hospital and Harvard Medical School, Boston, Massachusetts 02115
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Joseph J. Volpe
1Department of Neurology, Children’s Hospital and Harvard Medical School, Boston, Massachusetts 02115
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.18-16-06241.1998
PubMed 
9698317
Published By 
Society for Neuroscience
History 
  • Received April 13, 1998
  • Revision received May 27, 1998
  • Accepted June 8, 1998
  • First published August 15, 1998.
  • Version of record published August 15, 1998.
Copyright & Usage 
Copyright © 1998 Society for Neuroscience

Author Information

  1. Stephen A. Back,
  2. Xiaodong Gan,
  3. Ya Li,
  4. Paul A. Rosenberg, and
  5. Joseph J. Volpe
  1. 1Department of Neurology, Children’s Hospital and Harvard Medical School, Boston, Massachusetts 02115
View Full Text

Author contributions

Disclosures

    • Received April 13, 1998.
    • Revision received May 27, 1998.
    • Accepted June 8, 1998.
  • This research was supported by National Institutes of Health Grants NS01855 (S.A.B.) and P20NS32570 (P.A.R. and J.J.V.), National Institute of Child Health and Human Development Grant P30HD18655 (J.J.V.), a Grass Foundation Morison Fellowship (S.A.B.), a Reynolds Rich Smith Fellowship (S.A.B.), Charles A. Janeway Child Health Research Center Award Fellowship HD27805 (S.A.B.), and a Hearst Foundation Award (S.A.B.). We thank Dr. David Zurakowski for advice on the statistical analysis and Marcia Lind for excellent technical assistance.

    Correspondence should be addressed to Dr. Paul A. Rosenberg, Department of Neurology, Enders 3, Children’s Hospital, 300 Longwood Avenue, Boston, MA 02115.

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AbstractFullPdf
Jan 19997168
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Apr 2008191523
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Apr 20091267
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Total 2016139229409
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Feb 20177219
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Apr 2017133118
May 20179648
Jun 201753414
Jul 20172242
Aug 201781813
Sep 20176399
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Total 201796403139
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Feb 20184188
Mar 20184359
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May 201882621
Jun 20185366
Jul 201822910
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Total 202054223136
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Total 202195621
Total263565624180
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The Journal of Neuroscience: 18 (16)
Journal of Neuroscience
Vol. 18, Issue 16
15 Aug 1998
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Maturation-Dependent Vulnerability of Oligodendrocytes to Oxidative Stress-Induced Death Caused by Glutathione Depletion
Stephen A. Back, Xiaodong Gan, Ya Li, Paul A. Rosenberg, Joseph J. Volpe
Journal of Neuroscience 15 August 1998, 18 (16) 6241-6253; DOI: 10.1523/JNEUROSCI.18-16-06241.1998

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Maturation-Dependent Vulnerability of Oligodendrocytes to Oxidative Stress-Induced Death Caused by Glutathione Depletion
Stephen A. Back, Xiaodong Gan, Ya Li, Paul A. Rosenberg, Joseph J. Volpe
Journal of Neuroscience 15 August 1998, 18 (16) 6241-6253; DOI: 10.1523/JNEUROSCI.18-16-06241.1998
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Keywords

  • oligodendrocyte
  • glutathione
  • cystine
  • free radicals
  • oxidative stress
  • growth factor

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