Long-Term Desensitization of Nicotinic Acetylcholine Receptors Is Regulated via Protein Kinase A-Mediated Phosphorylation

This research was supported by Grant NS18205 from National Institutes of Health. We are grateful to Dr. Richard Mauer (Oregon Health Sciences Center, Portland, OR) for providing the PKA inhibitor cDNA and to Dr. Richard Kullberg (University of Alaska, Anchorage, AK) for providing all of the serine-alanine mutant cDNA clones. We also thank Dr. Craig Jahr (Vollum Institute, Portland, OR) for advice in designing the fast perfusion system.

Correspondence should be addressed to Dr. Paul Brehm, Department of Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook, NY 11794.