Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems

Christelle Peyron; Devin K. Tighe; Anthony N. van den Pol; Luis de Lecea; H. Craig Heller; J. Gregor Sutcliffe; Thomas S. Kilduff

doi:10.1523/JNEUROSCI.18-23-09996.1998

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.18-23-09996.1998

PubMed

9822755

Published By

Society for Neuroscience

History

Received July 15, 1998
Revision received September 11, 1998
Accepted September 15, 1998
First published December 1, 1998.

Version of record published December 1, 1998.

Author Information

Christelle Peyron1,
Devin K. Tighe1,
Anthony N. van den Pol1,3,
Luis de Lecea2,
H. Craig Heller1,
J. Gregor Sutcliffe2, and
Thomas S. Kilduff1

¹Department of Biological Sciences, Stanford University, Stanford, California 94305,
²Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, and
³Department of Neurosurgery, Yale University, New Haven, Connecticut 06520

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Author contributions

Disclosures

Received July 15, 1998.
Revision received September 11, 1998.
Accepted September 15, 1998.

This work was supported by National Institutes of Health Grants AG11084, GM32355, NS33396, and NS34887 and by Air Force Office of Scientific Research, the Army Research Office, and the Fyssen Fondation. We thank Dr. Peter O’Hara for use of his Neurolucida system (MicroBrightField, Colchester, VT) in the analysis of the distribution of hypocretin-immunoreactive fibers. We also thank Drs. Y. Yang for technical assistance with the electron microscopy, Chiaki Fukuhara who made the preprohypocretin used to raise antisera, Masashi Yanagisawa for the gift of orexin A, and Jean-Louis Nahon for the gift of melanin-concentrating hormone cDNA plasmid.
Correspondence should be addressed to Dr. Christelle Peyron, Department of Biological Sciences, Gilbert Hall, 371 Serra Mall, Stanford University, Stanford, CA 94305-5020.

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	Abstract	Full	Pdf
Jan 1999	8	29	23
Feb 1999	15	25	26
Mar 1999	5	48	28
Dec 1999	3	49	45
Total 1999	31	151	122
Jan 2000	9	36	26
Feb 2000	5	35	17
Mar 2000	16	49	24
Apr 2000	5	40	21
May 2000	1	39	20
Jun 2000	5	38	22
Jul 2000	3	34	29
Aug 2000	7	30	26
Sep 2000	23	74	60
Oct 2000	12	69	66
Nov 2000	10	84	66
Dec 2000	6	47	44
Total 2000	102	575	421
Jan 2001	2	60	53
Feb 2001	6	59	50
Mar 2001	3	52	41
Apr 2001	4	52	28
May 2001	4	56	67
Jun 2001	5	46	31
Jul 2001	8	25	23
Aug 2001	9	42	45
Sep 2001	4	38	23
Oct 2001	9	69	48
Nov 2001	10	42	36
Dec 2001	3	50	34
Total 2001	67	591	479
Jan 2002	12	84	83
Feb 2002	10	44	30
Mar 2002	23	63	61
Apr 2002	4	57	86
May 2002	1	25	47
Jun 2002	3	51	53
Jul 2002	3	31	49
Aug 2002	4	40	52
Sep 2002	6	39	61
Oct 2002	10	45	39
Nov 2002	8	55	45
Dec 2002	3	35	32
Total 2002	87	569	638
Jan 2003	10	31	23
Feb 2003	6	55	51
Mar 2003	10	48	46
Apr 2003	10	63	53
May 2003	10	58	61
Jun 2003	28	78	69
Jul 2003	35	63	55
Aug 2003	73	47	44
Sep 2003	56	59	50
Oct 2003	66	63	54
Nov 2003	42	75	67
Dec 2003	18	53	58
Total 2003	364	693	631
Jan 2004	23	48	33
Feb 2004	20	67	55
Mar 2004	27	93	81
Apr 2004	35	92	71
May 2004	41	61	54
Jun 2004	24	78	65
Jul 2004	21	51	57
Aug 2004	66	82	54
Sep 2004	28	54	39
Oct 2004	28	66	73
Nov 2004	32	105	66
Dec 2004	30	69	44
Total 2004	375	866	692
Jan 2005	19	80	55
Feb 2005	38	86	69
Mar 2005	39	113	73
Apr 2005	21	92	83
May 2005	13	55	36
Jun 2005	11	74	46
Jul 2005	22	74	53
Aug 2005	16	67	43
Sep 2005	20	80	70
Oct 2005	14	84	67
Nov 2005	14	61	57
Dec 2005	15	57	52
Total 2005	242	923	704
Jan 2006	9	106	52
Feb 2006	13	91	65
Mar 2006	9	119	73
Apr 2006	21	63	59
May 2006	44	71	74
Jun 2006	32	62	41
Jul 2006	22	54	44
Aug 2006	24	56	43
Sep 2006	38	62	53
Oct 2006	39	53	61
Nov 2006	37	104	85
Dec 2006	22	54	28
Total 2006	310	895	678
Jan 2007	34	67	66
Feb 2007	20	85	58
Mar 2007	38	94	84
Apr 2007	30	75	73
May 2007	18	59	52
Jun 2007	23	66	63
Jul 2007	20	60	50
Aug 2007	20	70	49
Sep 2007	24	70	44
Oct 2007	42	96	66
Nov 2007	32	108	60
Dec 2007	11	78	57
Total 2007	312	928	722
Jan 2008	25	86	72
Feb 2008	33	96	70
Mar 2008	36	89	82
Apr 2008	38	97	73
May 2008	28	68	74
Jun 2008	21	63	47
Jul 2008	21	68	52
Aug 2008	24	76	41
Sep 2008	25	61	50
Oct 2008	34	74	73
Nov 2008	31	74	71
Dec 2008	14	42	63
Total 2008	330	894	768
Jan 2009	47	43	57
Feb 2009	41	66	70
Mar 2009	38	77	59
Apr 2009	22	61	53
May 2009	24	42	60
Jun 2009	29	68	57
Jul 2009	14	42	39
Aug 2009	4	41	34
Sep 2009	28	75	74
Oct 2009	28	71	66
Nov 2009	30	58	66
Dec 2009	45	58	62
Total 2009	350	702	697
Jan 2010	24	52	47
Feb 2010	26	50	43
Mar 2010	29	104	71
Apr 2010	36	86	99
May 2010	24	91	89
Jun 2010	15	74	52
Jul 2010	15	81	44
Aug 2010	17	70	51
Sep 2010	33	88	62
Oct 2010	23	81	54
Nov 2010	47	139	102
Dec 2010	40	100	63
Total 2010	329	1016	777
Jan 2011	43	85	57
Feb 2011	148	91	56
Mar 2011	350	108	73
Apr 2011	310	89	71
May 2011	237	90	58
Jun 2011	185	82	60
Jul 2011	153	85	69
Aug 2011	166	71	74
Sep 2011	212	69	64
Oct 2011	280	107	68
Nov 2011	187	81	92
Dec 2011	179	90	73
Total 2011	2450	1048	815
Jan 2012	191	69	60
Feb 2012	175	87	93
Mar 2012	213	97	83
Apr 2012	216	111	76
May 2012	189	111	76
Jun 2012	176	102	61
Jul 2012	142	93	64
Aug 2012	141	71	51
Sep 2012	154	73	78
Oct 2012	202	101	86
Nov 2012	174	55	67
Dec 2012	197	55	95
Total 2012	2170	1025	890
Jan 2013	203	110	99
Feb 2013	215	62	54
Mar 2013	233	92	108
Apr 2013	187	76	109
May 2013	163	52	86
Jun 2013	143	55	145
Jul 2013	155	54	228
Aug 2013	175	59	302
Sep 2013	150	57	132
Oct 2013	203	59	191
Nov 2013	84	57	112
Dec 2013	50	50	89
Total 2013	1961	783	1655
Jan 2014	97	64	110
Feb 2014	80	57	131
Mar 2014	93	60	144
Apr 2014	94	79	165
May 2014	123	67	132
Jun 2014	87	64	101
Jul 2014	59	63	82
Aug 2014	84	59	107
Sep 2014	89	88	60
Oct 2014	86	70	78
Nov 2014	95	70	54
Dec 2014	184	84	49
Total 2014	1171	825	1213
Jan 2015	119	79	37
Feb 2015	67	89	42
Mar 2015	132	103	57
Apr 2015	117	92	61
May 2015	102	111	65
Jun 2015	98	112	62
Jul 2015	93	113	50
Aug 2015	105	119	41
Sep 2015	137	123	51
Oct 2015	111	192	46
Nov 2015	249	193	55
Dec 2015	128	209	61
Total 2015	1458	1535	628
Jan 2016	226	176	47
Feb 2016	323	183	53
Mar 2016	270	175	57
Apr 2016	201	168	47
May 2016	212	158	46
Jun 2016	224	124	47
Jul 2016	233	136	57
Aug 2016	196	89	36
Sep 2016	201	93	47
Oct 2016	142	143	65
Nov 2016	48	251	93
Dec 2016	43	277	51
Total 2016	2319	1973	646
Jan 2017	70	304	53
Feb 2017	60	297	49
Mar 2017	39	398	72
Apr 2017	29	251	53
May 2017	47	376	52
Jun 2017	41	237	44
Jul 2017	34	225	47
Aug 2017	49	387	30
Sep 2017	26	592	55
Oct 2017	54	478	47
Nov 2017	51	307	54
Dec 2017	38	223	36
Total 2017	538	4075	592
Jan 2018	24	144	55
Feb 2018	52	177	46
Mar 2018	75	142	66
Apr 2018	56	95	37
May 2018	33	114	33
Jun 2018	36	126	38
Jul 2018	20	90	45
Aug 2018	22	102	40
Sep 2018	27	105	45
Oct 2018	29	122	58
Nov 2018	36	170	69
Dec 2018	26	362	57
Total 2018	436	1749	589
Jan 2019	37	442	58
Feb 2019	36	183	57
Mar 2019	47	117	69
Apr 2019	76	100	49
May 2019	38	123	41
Jun 2019	24	134	37
Jul 2019	39	165	44
Aug 2019	40	498	51
Sep 2019	29	401	38
Oct 2019	47	651	46
Nov 2019	59	208	49
Dec 2019	24	73	30
Total 2019	496	3095	569
Jan 2020	18	121	63
Feb 2020	31	74	38
Mar 2020	18	79	42
Apr 2020	28	75	55
May 2020	46	118	87
Jun 2020	34	74	46
Jul 2020	34	79	48
Aug 2020	29	65	37
Sep 2020	36	148	58
Oct 2020	32	142	49
Nov 2020	74	129	81
Dec 2020	53	128	47
Total 2020	433	1232	651
Jan 2021	37	155	67
Feb 2021	22	146	63
Mar 2021	46	142	81
Apr 2021	15	71	31
Total 2021	120	514	242
Total	16451	26657	15819