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ARTICLE

Myelin Galactolipids Are Essential for Proper Node of Ranvier Formation in the CNS

Jeffrey L. Dupree, Timothy Coetzee, Andrew Blight, Kinuko Suzuki and Brian Popko
Journal of Neuroscience 1 March 1998, 18 (5) 1642-1649; DOI: https://doi.org/10.1523/JNEUROSCI.18-05-01642.1998
Jeffrey L. Dupree
1Neuroscience Center,
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Timothy Coetzee
1Neuroscience Center,
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Andrew Blight
2Department of Surgery, Division of Neurosurgery,
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Kinuko Suzuki
1Neuroscience Center,
3Department of Pathology and Laboratory Medicine,
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Brian Popko
1Neuroscience Center,
4Department of Biochemistry and Biophysics, and
5Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.18-05-01642.1998
PubMed 
9464989
Published By 
Society for Neuroscience
History 
  • Received August 26, 1997
  • Revision received November 19, 1997
  • Accepted December 5, 1997
  • First published March 1, 1998.
  • Version of record published March 1, 1998.
Copyright & Usage 
Copyright © 1998 Society for Neuroscience

Author Information

  1. Jeffrey L. Dupree1,
  2. Timothy Coetzee1,
  3. Andrew Blight2,
  4. Kinuko Suzuki1,3, and
  5. Brian Popko1,4,5
  1. 1Neuroscience Center,
  2. 2Department of Surgery, Division of Neurosurgery,
  3. 3Department of Pathology and Laboratory Medicine,
  4. 4Department of Biochemistry and Biophysics, and
  5. 5Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599
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Author contributions

Disclosures

    • Received August 26, 1997.
    • Revision received November 19, 1997.
    • Accepted December 5, 1997.
  • This work was supported by Grants NS27336 (B.P.), NS24453 (K.S.), and NS33687 (A.B.) from the National Institutes of Health and Mental Retardation Research Center Core Grant HD03110 from the National Institutes of Health. J.D. was supported by Training Grant HD07201 from the National Institutes of Health and an Advanced Postdoctoral Fellowship from the National Multiple Sclerosis Society. T.C. is a recipient of an Advanced Postdoctoral Fellowship from the National Multiple Sclerosis Society. B.P. is the recipient of Research Career Development Award NS01637 from the National Institutes of Health. We thank Clarita Langaman and Tom Kelly for their superb technical assistance with the electron microscopic and electrophysiological analysis, respectively. We also thank Dr. Jack Rosenbluth for his insightful critique of the electron micrographs and Dr. Kunihiko Suzuki for his assistance in the interpretation of the lipid analysis.

    Correspondence should be addressed to Dr. Brian Popko, Neuroscience Center, CB 7250, University of North Carolina, Chapel Hill, NC 27599-7250.

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The Journal of Neuroscience: 18 (5)
Journal of Neuroscience
Vol. 18, Issue 5
1 Mar 1998
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Myelin Galactolipids Are Essential for Proper Node of Ranvier Formation in the CNS
Jeffrey L. Dupree, Timothy Coetzee, Andrew Blight, Kinuko Suzuki, Brian Popko
Journal of Neuroscience 1 March 1998, 18 (5) 1642-1649; DOI: 10.1523/JNEUROSCI.18-05-01642.1998

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Myelin Galactolipids Are Essential for Proper Node of Ranvier Formation in the CNS
Jeffrey L. Dupree, Timothy Coetzee, Andrew Blight, Kinuko Suzuki, Brian Popko
Journal of Neuroscience 1 March 1998, 18 (5) 1642-1649; DOI: 10.1523/JNEUROSCI.18-05-01642.1998
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Keywords

  • node of Ranvier
  • galactocerebroside
  • sulfatide
  • myelin
  • UDP galactose:ceramide galactosyl transferase
  • axo-glial interaction

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