A Model Neuron with Activity-Dependent Conductances Regulated by Multiple Calcium Sensors

Zheng Liu; Jorge Golowasch; Eve Marder; L. F. Abbott

doi:10.1523/JNEUROSCI.18-07-02309.1998

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.18-07-02309.1998

PubMed

9502792

Published By

Society for Neuroscience

History

Received June 27, 1997
Revision received December 19, 1997
Accepted January 8, 1998
First published April 1, 1998.

Version of record published April 1, 1998.

Author Information

Zheng Liu,
Jorge Golowasch,
Eve Marder, and
L. F. Abbott

¹Volen Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02254

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Author contributions

Disclosures

Received June 27, 1997.
Revision received December 19, 1997.
Accepted January 8, 1998.

This work was supported by the Sloan Center for Theoretical Neurobiology at Brandeis University, National Institute of Mental Health Grant MH46742, the McKnight Foundation, and the W. M. Keck Foundation. We thank Mark Goldman for helpful consultation.
Correspondence should be addressed to Larry Abbott, Volen Center, MS 013, Brandeis University, 415 South Street, Waltham, MA 02254.

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	Abstract	Full	Pdf
Jan 1999	4	15	2
Feb 1999	4	9	2
Mar 1999	8	10	3
Dec 1999	1	17	2
Total 1999	17	51	9
Jan 2000	2	14	15
Feb 2000	5	12	2
Mar 2000	3	3	5
Apr 2000	2	8	3
May 2000	4	6	5
Jun 2000	2	10	6
Jul 2000	3	16	8
Aug 2000	2	8	6
Sep 2000	6	18	14
Oct 2000	5	22	15
Nov 2000	2	22	10
Dec 2000	8	16	4
Total 2000	44	155	93
Jan 2001	10	12	4
Feb 2001	2	6	3
Mar 2001	2	17	12
Apr 2001	4	16	10
May 2001	1	15	9
Jun 2001	2	16	8
Jul 2001	6	14	9
Aug 2001	3	13	5
Sep 2001	3	6	4
Oct 2001	0	13	5
Nov 2001	1	6	6
Dec 2001	2	15	8
Total 2001	36	149	83
Jan 2002	3	22	10
Feb 2002	0	13	11
Mar 2002	5	16	10
Apr 2002	1	10	4
May 2002	2	6	4
Jun 2002	0	8	6
Jul 2002	1	4	7
Aug 2002	0	4	5
Sep 2002	2	4	8
Oct 2002	3	15	9
Nov 2002	0	21	23
Dec 2002	0	8	11
Total 2002	17	131	108
Jan 2003	1	6	5
Feb 2003	3	15	12
Mar 2003	2	11	8
Apr 2003	1	10	7
May 2003	1	11	10
Jun 2003	1	9	11
Jul 2003	8	14	7
Aug 2003	12	20	15
Sep 2003	10	16	13
Oct 2003	8	27	14
Nov 2003	12	24	27
Dec 2003	16	29	13
Total 2003	75	192	142
Jan 2004	13	9	5
Feb 2004	11	19	10
Mar 2004	12	21	19
Apr 2004	14	16	15
May 2004	11	14	15
Jun 2004	14	24	16
Jul 2004	14	9	9
Aug 2004	20	23	19
Sep 2004	9	26	8
Oct 2004	11	37	4
Nov 2004	8	60	16
Dec 2004	16	48	9
Total 2004	153	306	145
Jan 2005	20	40	8
Feb 2005	15	50	14
Mar 2005	25	16	12
Apr 2005	3	15	8
May 2005	6	22	12
Jun 2005	10	20	12
Jul 2005	3	18	6
Aug 2005	7	19	7
Sep 2005	6	27	18
Oct 2005	10	31	8
Nov 2005	10	24	9
Dec 2005	10	25	15
Total 2005	125	307	129
Jan 2006	4	12	7
Feb 2006	10	21	10
Mar 2006	2	18	11
Apr 2006	1	17	11
May 2006	5	12	13
Jun 2006	8	16	11
Jul 2006	7	8	9
Aug 2006	4	16	13
Sep 2006	10	29	11
Oct 2006	6	17	10
Nov 2006	7	14	4
Dec 2006	5	17	9
Total 2006	69	197	119
Jan 2007	5	12	6
Feb 2007	5	13	15
Mar 2007	8	6	7
Apr 2007	2	8	5
May 2007	6	15	17
Jun 2007	5	11	9
Jul 2007	2	5	6
Aug 2007	3	16	12
Sep 2007	5	7	5
Oct 2007	3	9	4
Nov 2007	9	11	14
Dec 2007	6	8	12
Total 2007	59	121	112
Jan 2008	6	12	6
Feb 2008	13	19	31
Mar 2008	4	11	7
Apr 2008	4	10	12
May 2008	2	13	14
Jun 2008	10	11	7
Jul 2008	4	15	12
Aug 2008	9	11	10
Sep 2008	11	11	11
Oct 2008	16	12	10
Nov 2008	5	15	7
Dec 2008	8	8	6
Total 2008	92	148	133
Jan 2009	9	15	19
Feb 2009	6	13	11
Mar 2009	5	8	10
Apr 2009	9	5	9
May 2009	4	6	5
Jun 2009	3	8	8
Jul 2009	4	7	7
Aug 2009	5	18	10
Sep 2009	7	11	9
Oct 2009	3	17	15
Nov 2009	12	19	11
Dec 2009	5	5	6
Total 2009	72	132	120
Jan 2010	7	11	12
Feb 2010	6	8	5
Mar 2010	8	8	12
Apr 2010	6	11	10
May 2010	7	10	11
Jun 2010	7	9	7
Jul 2010	3	19	16
Aug 2010	4	13	10
Sep 2010	7	18	14
Oct 2010	12	15	10
Nov 2010	12	18	12
Dec 2010	7	8	2
Total 2010	86	148	121
Jan 2011	8	11	10
Feb 2011	3	10	7
Mar 2011	13	20	13
Apr 2011	8	17	5
May 2011	5	8	8
Jun 2011	15	9	15
Jul 2011	7	18	10
Aug 2011	6	28	33
Sep 2011	19	15	13
Oct 2011	11	15	11
Nov 2011	6	12	6
Dec 2011	4	11	9
Total 2011	105	174	140
Jan 2012	8	19	14
Feb 2012	8	11	10
Mar 2012	17	18	15
Apr 2012	13	12	9
May 2012	6	11	12
Jun 2012	11	14	6
Jul 2012	9	15	7
Aug 2012	3	12	5
Sep 2012	5	7	7
Oct 2012	10	4	0
Nov 2012	21	17	6
Dec 2012	31	13	10
Total 2012	142	153	101
Jan 2013	11	5	7
Feb 2013	4	20	3
Mar 2013	13	6	9
Apr 2013	19	14	19
May 2013	20	2	10
Jun 2013	14	9	11
Jul 2013	5	11	15
Aug 2013	5	7	6
Sep 2013	4	11	7
Oct 2013	14	8	5
Nov 2013	16	24	10
Dec 2013	9	13	39
Total 2013	134	130	141
Jan 2014	4	13	29
Feb 2014	12	8	52
Mar 2014	9	7	29
Apr 2014	17	17	7
May 2014	31	13	13
Jun 2014	5	14	6
Jul 2014	19	9	5
Aug 2014	13	16	6
Sep 2014	20	16	9
Oct 2014	14	13	11
Nov 2014	9	34	9
Dec 2014	12	46	7
Total 2014	165	206	183
Jan 2015	12	23	10
Feb 2015	17	10	2
Mar 2015	6	11	5
Apr 2015	16	17	10
May 2015	12	15	9
Jun 2015	4	9	3
Jul 2015	3	10	5
Aug 2015	4	12	6
Sep 2015	19	12	8
Oct 2015	9	22	7
Nov 2015	8	13	9
Dec 2015	15	4	7
Total 2015	125	158	81
Jan 2016	30	16	9
Feb 2016	16	38	21
Mar 2016	26	26	24
Apr 2016	16	32	13
May 2016	25	13	8
Jun 2016	22	33	24
Jul 2016	8	24	10
Aug 2016	16	15	10
Sep 2016	15	13	7
Oct 2016	13	26	15
Nov 2016	25	26	25
Dec 2016	2	58	15
Total 2016	214	320	181
Jan 2017	3	50	2
Feb 2017	1	43	7
Mar 2017	6	63	30
Apr 2017	6	21	14
May 2017	9	62	9
Jun 2017	2	30	24
Jul 2017	1	17	18
Aug 2017	3	21	14
Sep 2017	2	24	12
Oct 2017	5	26	22
Nov 2017	12	37	19
Dec 2017	7	8	7
Total 2017	57	402	178
Jan 2018	6	19	15
Feb 2018	4	26	11
Mar 2018	4	10	13
Apr 2018	5	29	20
May 2018	8	32	16
Jun 2018	2	44	17
Jul 2018	3	21	26
Aug 2018	3	18	16
Sep 2018	1	35	5
Oct 2018	3	19	7
Nov 2018	1	20	5
Dec 2018	2	11	6
Total 2018	42	284	157
Jan 2019	5	15	10
Feb 2019	10	26	17
Mar 2019	6	27	21
Apr 2019	2	20	13
May 2019	16	17	19
Jun 2019	9	17	17
Jul 2019	11	16	16
Aug 2019	6	32	18
Sep 2019	4	32	13
Oct 2019	8	64	12
Nov 2019	6	33	18
Dec 2019	2	16	23
Total 2019	85	315	197
Jan 2020	4	23	17
Feb 2020	3	20	12
Mar 2020	2	10	14
Apr 2020	4	19	6
May 2020	4	33	26
Jun 2020	3	26	18
Jul 2020	7	15	11
Aug 2020	7	11	10
Sep 2020	2	25	7
Oct 2020	7	36	10
Nov 2020	12	38	14
Dec 2020	6	46	26
Total 2020	61	302	171
Jan 2021	2	30	14
Feb 2021	6	43	16
Mar 2021	6	51	10
Apr 2021	8	35	20
May 2021	2	44	13
Jun 2021	8	51	20
Jul 2021	3	19	15
Aug 2021	9	27	9
Sep 2021	6	33	9
Oct 2021	8	19	18
Total 2021	58	352	144
Total	2033	4833	2988