Protein Kinase C Disrupts Cannabinoid Actions by Phosphorylation of the CB1 Cannabinoid Receptor

This work was supported by the W. M. Keck Foundation, an Alexander von Humboldt Stiftung Fellowship, Universidad Nacional Autonoma de Mexico DGAPA and Consejo Nacional de Ciencia y Tecnologia, and National Institutes of Health Grants NS01588, DA08934, DA00286, and NS08174. We thank A. Perdichezzi and B. Murphy for help with phosphorylation assays, D. Anderson and L. Miller for technical help, W. Catterall, H. Cruzblanca, J. Isaacson, E. Kaftan, K.T. Kim, D.-S. Koh, J. Roche, and M. Shapiro for reading this manuscript, Y. Lai and A. Nairn for providing protein kinase C, and Sterling Winthrop for providing WIN 55,212-2.

Correspondence should be addressed to Dr. Ken Mackie, University of Washington, Department of Anesthesiology, Box 356540, Seattle, WA 98195-6540.