Article Figures & Data
Figures
- Fig. 1.
Quantitative computerized image analysis was performed over the indicated shaded areas. Analysis was performed at approximately the level of bregma 1.60 mm [figure modified from plate 12 in Paxinos and Watson (1997)].lCPu, Lateral caudate putamen; mCPu, medial caudate putamen; AcbSh, accumbens shell;AcbC, accumbens core; c.ctx, cingulate cortex; m.ctx, motor cortex; s.ctx, sensory cortex.
- Fig. 2.
Running behavior in running wheels. Lewis and Fischer rats were individually housed and had free access to running wheels for 30 d. Activity in the wheels is converted to meters. The rats were mostly active during nights. Values are means ± SEM (n = 8).
- Fig. 3.
Film autoradiograms after in situhybridization using 48-mer oligonucleotide DNA probes to detect mRNA distribution and regulation of NFGI-B (A) and Nor1 (B) mRNA levels in rats that were individually housed and had free access to running wheels for 30 d. Control rats were individually housed for 30 d without access to running wheels.
- Fig. 4.
Relative levels of NGFI-B and Nor1 mRNA in control rats that were individually housed for 30 d without access to running wheels and compared with runners with access to running wheels. For abbreviations, see Figure 1. Values are means ± SEM (n = 8). +p < 0.05; ++p < 0.01, significance for higher basal level in the indicated strain; *p < 0.05; **p < 0.01, indicates significantly lower levels of the respective mRNA after running.
- Fig. 5.
Relative levels of NGFI-B and Nor1 mRNA in saline-injected control animals (Saline) without access to running wheels, naloxone-treated (2 mg/kg, s.c) rats with (Running + Naloxone) and without (Naloxone) free access to running. The animals were killed 2 hr after injections. For abbreviations, see Figure 1. Values are means ± SEM (n = 6–8). *p < 0.05; **p < 0.01; ***p < 0.001, indicates significant difference when comparing saline-injected control animals with naloxone-treated animals or animals with access to running wheels and naloxone. +p < 0.05; ++ p < 0.01; +++p < 0.001, indicates significant differences when comparing naloxone treated animals without access to running wheels with animals receiving naloxone with access to running wheels.
