Allosteric Control of Gating and Kinetics at P2X₄Receptor Channels

This work was supported by a Wellcome Trust (UK) International Prize Fellowship (to B.S.K.), National Institutes of Health Grant NS-11756 and NS-29173, and grants from the Department of Veterans Affairs. Thanks to Dr. I Chessell (Glaxo Wellcome) for providing P2X cDNA clones and Dr. Phillipe Seguela for the P2X₆ cDNA. We thank S. McKinney and H. Li for help with preparation of hippocampal cultures and Xenopus oocytes and W. B. Smith for guidance on use of the Biolistics gene gun.

Correspondence should be addressed to Baljit S. Khakh, Division of Biology, 156-29, California Institute of Technology, Pasadena, CA 91125.