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ARTICLE

Reversals of Age-Related Declines in Neuronal Signal Transduction, Cognitive, and Motor Behavioral Deficits with Blueberry, Spinach, or Strawberry Dietary Supplementation

James A. Joseph, Barbara Shukitt-Hale, Natalia A. Denisova, Donna Bielinski, Antonio Martin, John J. McEwen and Paula C. Bickford
Journal of Neuroscience 15 September 1999, 19 (18) 8114-8121; DOI: https://doi.org/10.1523/JNEUROSCI.19-18-08114.1999
James A. Joseph
1United States Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, and
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Barbara Shukitt-Hale
1United States Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, and
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Natalia A. Denisova
1United States Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, and
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Donna Bielinski
1United States Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, and
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Antonio Martin
1United States Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, and
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John J. McEwen
1United States Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, and
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Paula C. Bickford
2Department of Veterans Affairs Medical Center, Denver, Colorado 80262
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Abstract

Ample research indicates that age-related neuronal–behavioral decrements are the result of oxidative stress that may be ameliorated by antioxidants. Our previous study had shown that rats given dietary supplements of fruit and vegetable extracts with high antioxidant activity for 8 months beginning at 6 months of age retarded age-related declines in neuronal and cognitive function. The present study showed that such supplements (strawberry, spinach, or blueberry at 14.8, 9.1, or 18.6 gm of dried aqueous extract per kilogram of diet, respectively) fed for 8 weeks to 19-month-old Fischer 344 rats were also effective in reversing age-related deficits in several neuronal and behavioral parameters including: oxotremorine enhancement of K+-evoked release of dopamine from striatal slices, carbachol-stimulated GTPase activity, striatal Ca45buffering in striatal synaptosomes, motor behavioral performance on the rod walking and accelerod tasks, and Morris water maze performance. These findings suggest that, in addition to their known beneficial effects on cancer and heart disease, phytochemicals present in antioxidant-rich foods may be beneficial in reversing the course of neuronal and behavioral aging.

  • phytonutrients
  • aging
  • dopamine
  • striatum
  • cognitive behavior
  • motor behavior
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The Journal of Neuroscience: 19 (18)
Journal of Neuroscience
Vol. 19, Issue 18
15 Sep 1999
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Reversals of Age-Related Declines in Neuronal Signal Transduction, Cognitive, and Motor Behavioral Deficits with Blueberry, Spinach, or Strawberry Dietary Supplementation
James A. Joseph, Barbara Shukitt-Hale, Natalia A. Denisova, Donna Bielinski, Antonio Martin, John J. McEwen, Paula C. Bickford
Journal of Neuroscience 15 September 1999, 19 (18) 8114-8121; DOI: 10.1523/JNEUROSCI.19-18-08114.1999

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Reversals of Age-Related Declines in Neuronal Signal Transduction, Cognitive, and Motor Behavioral Deficits with Blueberry, Spinach, or Strawberry Dietary Supplementation
James A. Joseph, Barbara Shukitt-Hale, Natalia A. Denisova, Donna Bielinski, Antonio Martin, John J. McEwen, Paula C. Bickford
Journal of Neuroscience 15 September 1999, 19 (18) 8114-8121; DOI: 10.1523/JNEUROSCI.19-18-08114.1999
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Keywords

  • phytonutrients
  • aging
  • dopamine
  • striatum
  • cognitive behavior
  • motor behavior

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