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ARTICLE

Olfactory Neurons Expressing Closely Linked and Homologous Odorant Receptor Genes Tend to Project Their Axons to Neighboring Glomeruli on the Olfactory Bulb

Akio Tsuboi, Sei-ichi Yoshihara, Nika Yamazaki, Hiroaki Kasai, Hisae Asai-Tsuboi, Madoka Komatsu, Shou Serizawa, Tomohiro Ishii, Yoichi Matsuda, Fumikiyo Nagawa and Hitoshi Sakano
Journal of Neuroscience 1 October 1999, 19 (19) 8409-8418; https://doi.org/10.1523/JNEUROSCI.19-19-08409.1999
Akio Tsuboi
1Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Tokyo 113–0032, Japan,
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Sei-ichi Yoshihara
1Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Tokyo 113–0032, Japan,
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Nika Yamazaki
2Department of Cell Biology, National Institute for Basic Biology, Okazaki 444–8585, Japan, and
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Hiroaki Kasai
2Department of Cell Biology, National Institute for Basic Biology, Okazaki 444–8585, Japan, and
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Hisae Asai-Tsuboi
2Department of Cell Biology, National Institute for Basic Biology, Okazaki 444–8585, Japan, and
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Madoka Komatsu
1Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Tokyo 113–0032, Japan,
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Shou Serizawa
1Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Tokyo 113–0032, Japan,
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Tomohiro Ishii
1Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Tokyo 113–0032, Japan,
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Yoichi Matsuda
3Laboratory of Animal Genetics, Graduate School of Agricultural Sciences, Nagoya University, Nagoya 464–8601, Japan
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Fumikiyo Nagawa
1Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Tokyo 113–0032, Japan,
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Hitoshi Sakano
1Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Tokyo 113–0032, Japan,
2Department of Cell Biology, National Institute for Basic Biology, Okazaki 444–8585, Japan, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.19-19-08409.1999
PubMed 
10493742
Published By 
Society for Neuroscience
History 
  • Received March 25, 1999
  • Revision received July 16, 1999
  • Accepted July 21, 1999
  • First published October 1, 1999.
  • Version of record published October 1, 1999.
Copyright & Usage 
Copyright © 1999 Society for Neuroscience

Author Information

  1. Akio Tsuboi1,
  2. Sei-ichi Yoshihara1,
  3. Nika Yamazaki2,
  4. Hiroaki Kasai2,
  5. Hisae Asai-Tsuboi2,
  6. Madoka Komatsu1,
  7. Shou Serizawa1,
  8. Tomohiro Ishii1,
  9. Yoichi Matsuda3,
  10. Fumikiyo Nagawa1, and
  11. Hitoshi Sakano1,2
  1. 1Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Tokyo 113–0032, Japan,
  2. 2Department of Cell Biology, National Institute for Basic Biology, Okazaki 444–8585, Japan, and
  3. 3Laboratory of Animal Genetics, Graduate School of Agricultural Sciences, Nagoya University, Nagoya 464–8601, Japan
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Author contributions

Disclosures

    • Received March 25, 1999.
    • Revision received July 16, 1999.
    • Accepted July 21, 1999.
  • This work was supported by the Special Promotion Research Grant from the Ministry of Education and Culture of Japan and by grants from Toray Science Foundation, Nissan Science Foundation, Mitsubishi Foundation, and Sumitomo Foundation. A.T. was supported by fellowships from the Daikou Foundation and the Tohkai Foundation for the Promotion of Industry and Technology. We thank Drs. Hiroshi Kiyama (Asahikawa Medical School), Ichiro Naruse (Kyoto University), and Tetsuo Yamamori (Institute for Basic Biology) for helpful discussion and suggestions, and Dr. Anthony J. Otsuka (Illinois State University) and Ms. Hitomi Sakano (University of California at Berkeley) for critical reading of this manuscript.

    Dr. Tsuboi and Mr. Yoshihara contributed equally to this work.

    The DDBJ accession numbers for the sequences reported in this paper areAB030892-AB030896.

    Correspondence should be addressed to Dr. Akio Tsuboi, Room 111B, Science Building #3, Department of Biophysics and Biochemistry, University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113–0032, Japan.

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The Journal of Neuroscience: 19 (19)
Journal of Neuroscience
Vol. 19, Issue 19
1 Oct 1999
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Olfactory Neurons Expressing Closely Linked and Homologous Odorant Receptor Genes Tend to Project Their Axons to Neighboring Glomeruli on the Olfactory Bulb
Akio Tsuboi, Sei-ichi Yoshihara, Nika Yamazaki, Hiroaki Kasai, Hisae Asai-Tsuboi, Madoka Komatsu, Shou Serizawa, Tomohiro Ishii, Yoichi Matsuda, Fumikiyo Nagawa, Hitoshi Sakano
Journal of Neuroscience 1 October 1999, 19 (19) 8409-8418; DOI: 10.1523/JNEUROSCI.19-19-08409.1999

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Olfactory Neurons Expressing Closely Linked and Homologous Odorant Receptor Genes Tend to Project Their Axons to Neighboring Glomeruli on the Olfactory Bulb
Akio Tsuboi, Sei-ichi Yoshihara, Nika Yamazaki, Hiroaki Kasai, Hisae Asai-Tsuboi, Madoka Komatsu, Shou Serizawa, Tomohiro Ishii, Yoichi Matsuda, Fumikiyo Nagawa, Hitoshi Sakano
Journal of Neuroscience 1 October 1999, 19 (19) 8409-8418; DOI: 10.1523/JNEUROSCI.19-19-08409.1999
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Keywords

  • axonal projection
  • odorant receptor gene
  • olfactory bulb
  • olfactory epithelium
  • olfactory sensory map
  • gene cluster

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