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ARTICLE

Calcium Channel Types with Distinct Presynaptic Localization Couple Differentially to Transmitter Release in Single Calyx-Type Synapses

Ling-Gang Wu, Ruth E. Westenbroek, J. Gerard G. Borst, William A. Catterall and Bert Sakmann
Journal of Neuroscience 15 January 1999, 19 (2) 726-736; https://doi.org/10.1523/JNEUROSCI.19-02-00726.1999
Ling-Gang Wu
1Abteilung Zellphysiologie, Max-Planck-Institut für medizinische Forschung, D-69120 Heidelberg, Germany, and
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Ruth E. Westenbroek
2Department of Pharmacology, University of Washington, Seattle, Washington 98195-7280
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J. Gerard G. Borst
1Abteilung Zellphysiologie, Max-Planck-Institut für medizinische Forschung, D-69120 Heidelberg, Germany, and
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William A. Catterall
2Department of Pharmacology, University of Washington, Seattle, Washington 98195-7280
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Bert Sakmann
1Abteilung Zellphysiologie, Max-Planck-Institut für medizinische Forschung, D-69120 Heidelberg, Germany, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.19-02-00726.1999
PubMed 
9880593
Published By 
Society for Neuroscience
History 
  • Received August 19, 1998
  • Revision received October 28, 1998
  • Accepted October 29, 1998
  • First published January 15, 1999.
  • Version of record published January 15, 1999.
Copyright & Usage 
Copyright © 1999 Society for Neuroscience

Author Information

  1. Ling-Gang Wu1,
  2. Ruth E. Westenbroek2,
  3. J. Gerard G. Borst1,
  4. William A. Catterall2, and
  5. Bert Sakmann1
  1. 1Abteilung Zellphysiologie, Max-Planck-Institut für medizinische Forschung, D-69120 Heidelberg, Germany, and
  2. 2Department of Pharmacology, University of Washington, Seattle, Washington 98195-7280
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Author contributions

Disclosures

    • Received August 19, 1998.
    • Revision received October 28, 1998.
    • Accepted October 29, 1998.
  • L.G.W. was supported by the Alexander von Humboldt Foundation and Human Frontier Science Program. J.G.G.B. was supported by a Training and Mobility of Researchers fellowship. R.E.W. and W.A.C. were supported by National Institutes of Health Grant NS22625. We thank Drs. Erwin Neher and Bernard Katz for helpful comments on this manuscript.

    Correspondence should be addressed to Dr. Ling-Gang Wu, Abteilung Zellphysiologie, Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, D-69120 Heidelberg, Germany.

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The Journal of Neuroscience: 19 (2)
Journal of Neuroscience
Vol. 19, Issue 2
15 Jan 1999
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Calcium Channel Types with Distinct Presynaptic Localization Couple Differentially to Transmitter Release in Single Calyx-Type Synapses
Ling-Gang Wu, Ruth E. Westenbroek, J. Gerard G. Borst, William A. Catterall, Bert Sakmann
Journal of Neuroscience 15 January 1999, 19 (2) 726-736; DOI: 10.1523/JNEUROSCI.19-02-00726.1999

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Calcium Channel Types with Distinct Presynaptic Localization Couple Differentially to Transmitter Release in Single Calyx-Type Synapses
Ling-Gang Wu, Ruth E. Westenbroek, J. Gerard G. Borst, William A. Catterall, Bert Sakmann
Journal of Neuroscience 15 January 1999, 19 (2) 726-736; DOI: 10.1523/JNEUROSCI.19-02-00726.1999
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Keywords

  • Ca2+ channels
  • presynaptic
  • calyx of Held
  • voltage clamp
  • antibody
  • immunocytochemistry
  • P-type Ca2+ channels
  • N-type Ca2+channels
  • R-type Ca2+ channels
  • synaptotagmin
  • fura-2
  • rat

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