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ARTICLE, Behavioral/Systems

Upregulation of GABA Neurotransmission Suppresses Hippocampal Excitability and Prevents Long-Term Potentiation in Transgenic Superoxide Dismutase-Overexpressing Mice

Y. Levkovitz, E. Avignone, Y. Groner and M. Segal
Journal of Neuroscience 15 December 1999, 19 (24) 10977-10984; DOI: https://doi.org/10.1523/JNEUROSCI.19-24-10977.1999
Y. Levkovitz
1Departments of Neurobiology and
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E. Avignone
1Departments of Neurobiology and
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Y. Groner
2Molecular Genetics, The Weizmann Institute, Rehovot 76100, Israel
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M. Segal
1Departments of Neurobiology and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.19-24-10977.1999
PubMed 
10594078
Published By 
Society for Neuroscience
History 
  • Received August 10, 1999
  • Revision received September 24, 1999
  • Accepted September 28, 1999
  • First published December 15, 1999.
  • Version of record published December 15, 1999.
Copyright & Usage 
Copyright © 1999 Society for Neuroscience

Author Information

  1. Y. Levkovitz1,
  2. E. Avignone1,
  3. Y. Groner2, and
  4. M. Segal1
  1. 1Departments of Neurobiology and
  2. 2Molecular Genetics, The Weizmann Institute, Rehovot 76100, Israel
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Author contributions

Disclosures

    • Received August 10, 1999.
    • Revision received September 24, 1999.
    • Accepted September 28, 1999.
  • This work was supported by grants from the Biomedicine and Health research program BIOMED II, number PL963039 of the Commission of the European Community, the Israeli Ministry of Science, and the Shapell family foundation at the Weizmann Institute and by the Edward Kass Award to Y.L.

    Correspondence should be addressed to M. Segal, Department of Neurobiology, The Weizmann Institute, Rehovot 76100, Israel. E-mail:jnsegal{at}weizmann.weizmann.ac.il.

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The Journal of Neuroscience: 19 (24)
Journal of Neuroscience
Vol. 19, Issue 24
15 Dec 1999
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Upregulation of GABA Neurotransmission Suppresses Hippocampal Excitability and Prevents Long-Term Potentiation in Transgenic Superoxide Dismutase-Overexpressing Mice
Y. Levkovitz, E. Avignone, Y. Groner, M. Segal
Journal of Neuroscience 15 December 1999, 19 (24) 10977-10984; DOI: 10.1523/JNEUROSCI.19-24-10977.1999

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Upregulation of GABA Neurotransmission Suppresses Hippocampal Excitability and Prevents Long-Term Potentiation in Transgenic Superoxide Dismutase-Overexpressing Mice
Y. Levkovitz, E. Avignone, Y. Groner, M. Segal
Journal of Neuroscience 15 December 1999, 19 (24) 10977-10984; DOI: 10.1523/JNEUROSCI.19-24-10977.1999
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Keywords

  • transgenic SOD-1 mice
  • LTP
  • seizure
  • hippocampus
  • IPSCs
  • perforant path

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