Temporally Graded Retrograde Amnesia of Contextual Fear after Hippocampal Damage in Rats: Within-Subjects Examination

Stephan G. Anagnostaras; Stephen Maren; Michael S. Fanselow

doi:10.1523/JNEUROSCI.19-03-01106.1999

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.19-03-01106.1999

PubMed

9920672

Published By

Society for Neuroscience

History

Received August 13, 1998
Revision received October 27, 1998
Accepted November 16, 1998
First published February 1, 1999.

Version of record published February 1, 1999.

Author Information

Stephan G. Anagnostaras1,
Stephen Maren2, and
Michael S. Fanselow1

¹Department of Psychology and Brain Research Institute, University of California, Los Angeles, California 90095-1563, and
²Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109

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Author contributions

Disclosures

Received August 13, 1998.
Revision received October 27, 1998.
Accepted November 16, 1998.

This research was supported by National Science Foundation Grant IBN 9723295 (M.S.F). S.A. was supported by a University of California at Los Angeles (UCLA) C. M. Kernan Dissertation Year Fellowship. S.M. was supported by individual National Institute of Mental Health National Research Service Award MH 11061. We thank Bernard Balleine, Paul Frankland, Jeansok Kim, Barbara Knowlton, Frank Krasne, Tom O’Dell, Jennifer Sage, Alcino Silva, and two anonymous reviewers for their thoughtful comments on an earlier version of this manuscript. We also thank Jennifer Sage and Jennifer Spooner for excellent technical assistance. An earlier version of this manuscript was part of S.A.’s UCLA doctoral dissertation.
Correspondence should be addressed to Stephan Anagnostaras, University of California at Los Angeles, Department of Psychology, 1285 Franz Hall, Los Angeles, CA 90095-1563.

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	Abstract	Full	Pdf
Jan 1999	196	148	162
Feb 1999	66	128	84
Mar 1999	13	39	33
Dec 1999	9	10	6
Total 1999	284	325	285
Jan 2000	8	22	12
Feb 2000	13	20	24
Mar 2000	17	30	9
Apr 2000	15	29	19
May 2000	9	28	12
Jun 2000	4	14	15
Jul 2000	2	11	6
Aug 2000	9	17	12
Sep 2000	14	30	24
Oct 2000	12	34	25
Nov 2000	28	35	16
Dec 2000	16	40	19
Total 2000	147	310	193
Jan 2001	19	17	11
Feb 2001	25	20	27
Mar 2001	27	35	25
Apr 2001	33	26	15
May 2001	30	24	16
Jun 2001	33	21	16
Jul 2001	12	18	20
Aug 2001	15	38	23
Sep 2001	9	17	11
Oct 2001	9	18	10
Nov 2001	12	22	11
Dec 2001	8	27	19
Total 2001	232	283	204
Jan 2002	6	33	22
Feb 2002	28	27	15
Mar 2002	18	33	21
Apr 2002	27	14	13
May 2002	20	38	253
Jun 2002	18	21	188
Jul 2002	35	23	13
Aug 2002	15	15	21
Sep 2002	4	11	13
Oct 2002	4	19	15
Nov 2002	2	17	35
Dec 2002	7	18	17
Total 2002	184	269	626
Jan 2003	6	14	13
Feb 2003	3	30	18
Mar 2003	6	21	17
Apr 2003	2	26	23
May 2003	3	31	26
Jun 2003	4	22	18
Jul 2003	12	19	17
Aug 2003	16	17	16
Sep 2003	9	26	19
Oct 2003	11	20	15
Nov 2003	11	30	43
Dec 2003	15	20	14
Total 2003	98	276	239
Jan 2004	27	25	24
Feb 2004	20	24	23
Mar 2004	34	20	21
Apr 2004	25	42	25
May 2004	33	31	16
Jun 2004	27	21	29
Jul 2004	20	19	11
Aug 2004	36	48	20
Sep 2004	40	49	14
Oct 2004	37	61	25
Nov 2004	31	61	22
Dec 2004	46	34	7
Total 2004	376	435	237
Jan 2005	39	46	31
Feb 2005	32	82	33
Mar 2005	45	50	28
Apr 2005	17	48	20
May 2005	25	31	17
Jun 2005	23	25	15
Jul 2005	19	29	18
Aug 2005	19	20	11
Sep 2005	22	26	9
Oct 2005	23	41	26
Nov 2005	32	36	37
Dec 2005	23	39	33
Total 2005	319	473	278
Jan 2006	21	45	28
Feb 2006	7	32	16
Mar 2006	12	41	17
Apr 2006	18	31	12
May 2006	15	14	15
Jun 2006	12	13	7
Jul 2006	10	15	13
Aug 2006	11	23	24
Sep 2006	20	26	22
Oct 2006	23	29	29
Nov 2006	37	25	28
Dec 2006	38	36	28
Total 2006	224	330	239
Jan 2007	22	13	21
Feb 2007	36	32	32
Mar 2007	41	27	22
Apr 2007	33	23	34
May 2007	35	29	22
Jun 2007	18	27	17
Jul 2007	19	13	19
Aug 2007	13	8	10
Sep 2007	12	17	16
Oct 2007	30	18	27
Nov 2007	44	33	28
Dec 2007	27	16	22
Total 2007	330	256	270
Jan 2008	8	10	10
Feb 2008	24	17	16
Mar 2008	40	20	16
Apr 2008	39	25	26
May 2008	30	24	18
Jun 2008	21	23	13
Jul 2008	27	22	19
Aug 2008	22	20	15
Sep 2008	17	14	9
Oct 2008	39	20	20
Nov 2008	31	16	22
Dec 2008	40	17	25
Total 2008	338	228	209
Jan 2009	19	15	15
Feb 2009	23	16	16
Mar 2009	36	27	30
Apr 2009	33	11	19
May 2009	18	23	21
Jun 2009	30	14	28
Jul 2009	6	16	10
Aug 2009	10	22	14
Sep 2009	25	27	17
Oct 2009	33	20	27
Nov 2009	38	22	23
Dec 2009	23	17	19
Total 2009	294	230	239
Jan 2010	21	17	18
Feb 2010	15	21	22
Mar 2010	31	23	21
Apr 2010	27	36	19
May 2010	21	31	19
Jun 2010	14	18	20
Jul 2010	14	19	19
Aug 2010	21	29	27
Sep 2010	20	32	34
Oct 2010	31	24	54
Nov 2010	33	43	45
Dec 2010	19	37	19
Total 2010	267	330	317
Jan 2011	21	28	25
Feb 2011	13	23	15
Mar 2011	32	32	32
Apr 2011	37	41	39
May 2011	34	31	31
Jun 2011	15	26	31
Jul 2011	15	15	17
Aug 2011	32	33	40
Sep 2011	24	17	26
Oct 2011	44	33	38
Nov 2011	47	33	63
Dec 2011	42	14	77
Total 2011	356	326	434
Jan 2012	38	31	41
Feb 2012	25	38	41
Mar 2012	44	36	56
Apr 2012	41	39	45
May 2012	23	28	39
Jun 2012	17	22	32
Jul 2012	18	28	29
Aug 2012	19	21	24
Sep 2012	23	38	27
Oct 2012	26	58	50
Nov 2012	86	25	52
Dec 2012	42	9	46
Total 2012	402	373	482
Jan 2013	31	26	42
Feb 2013	27	31	34
Mar 2013	47	16	58
Apr 2013	46	32	66
May 2013	57	39	42
Jun 2013	18	27	24
Jul 2013	14	28	31
Aug 2013	13	13	16
Sep 2013	26	17	21
Oct 2013	54	18	65
Nov 2013	52	31	51
Dec 2013	50	38	57
Total 2013	435	316	507
Jan 2014	39	22	30
Feb 2014	30	28	35
Mar 2014	33	39	75
Apr 2014	59	31	86
May 2014	59	28	94
Jun 2014	26	17	38
Jul 2014	27	32	30
Aug 2014	18	15	31
Sep 2014	32	14	49
Oct 2014	25	43	48
Nov 2014	46	47	79
Dec 2014	19	42	49
Total 2014	413	358	644
Jan 2015	18	22	46
Feb 2015	50	42	40
Mar 2015	44	42	58
Apr 2015	37	49	57
May 2015	134	49	51
Jun 2015	20	34	28
Jul 2015	15	33	7
Aug 2015	16	22	12
Sep 2015	24	32	14
Oct 2015	61	23	19
Nov 2015	29	25	17
Dec 2015	50	26	24
Total 2015	498	399	373
Jan 2016	40	39	27
Feb 2016	21	26	33
Mar 2016	28	54	51
Apr 2016	19	44	6
May 2016	10	25	9
Jun 2016	19	27	21
Jul 2016	9	185	24
Aug 2016	11	47	15
Sep 2016	11	53	21
Oct 2016	7	56	11
Nov 2016	6	52	11
Dec 2016	4	87	4
Total 2016	185	695	233
Jan 2017	1	43	4
Feb 2017	2	62	10
Mar 2017	29	87	20
Apr 2017	23	55	13
May 2017	33	81	24
Jun 2017	16	42	14
Jul 2017	9	21	9
Aug 2017	3	34	15
Sep 2017	14	55	17
Oct 2017	46	76	40
Nov 2017	27	157	29
Dec 2017	18	149	14
Total 2017	221	862	209
Jan 2018	13	121	16
Feb 2018	23	223	14
Mar 2018	32	69	19
Apr 2018	41	81	69
May 2018	22	72	13
Jun 2018	7	95	11
Jul 2018	9	77	18
Aug 2018	9	40	13
Sep 2018	17	52	14
Oct 2018	12	90	32
Nov 2018	24	103	21
Dec 2018	20	66	20
Total 2018	229	1089	260
Jan 2019	10	62	24
Feb 2019	13	47	12
Mar 2019	13	88	20
Apr 2019	21	66	27
May 2019	18	60	34
Jun 2019	10	45	10
Jul 2019	8	51	18
Aug 2019	4	32	11
Sep 2019	11	51	22
Oct 2019	18	87	29
Nov 2019	26	86	33
Dec 2019	15	44	25
Total 2019	167	719	265
Jan 2020	4	41	8
Feb 2020	7	31	9
Mar 2020	11	86	20
Apr 2020	20	73	20
May 2020	9	54	19
Jun 2020	8	32	16
Jul 2020	14	28	6
Aug 2020	4	19	8
Sep 2020	9	74	32
Oct 2020	9	86	24
Nov 2020	18	63	29
Dec 2020	13	59	20
Total 2020	126	646	211
Jan 2021	16	47	27
Feb 2021	10	48	16
Mar 2021	21	109	39
Apr 2021	20	66	50
May 2021	26	95	33
Jun 2021	12	59	24
Jul 2021	13	37	28
Aug 2021	19	55	29
Sep 2021	18	48	27
Oct 2021	14	70	98
Nov 2021	15	43	63
Dec 2021	8	57	40
Total 2021	192	734	474
Jan 2022	4	48	31
Feb 2022	3	37	11
Mar 2022	14	70	36
Apr 2022	21	57	21
May 2022	21	59	50
Jun 2022	9	46	20
Total 2022	72	317	169
Total	6389	10579	7597