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ARTICLE

Ca2+-Induced Deprotonation of Peptide Hormones Inside Secretory Vesicles in Preparation for Release

Weiping Han, Danqing Li, Amy K. Stout, Koichi Takimoto and Edwin S. Levitan
Journal of Neuroscience 1 February 1999, 19 (3) 900-905; DOI: https://doi.org/10.1523/JNEUROSCI.19-03-00900.1999
Weiping Han
1Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
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Danqing Li
1Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
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Amy K. Stout
1Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
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Koichi Takimoto
1Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
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Edwin S. Levitan
1Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.19-03-00900.1999
PubMed 
9920653
Published By 
Society for Neuroscience
History 
  • Received October 8, 1998
  • Revision received November 10, 1998
  • Accepted November 16, 1998
  • First published February 1, 1999.
  • Version of record published February 1, 1999.
Copyright & Usage 
Copyright © 1999 Society for Neuroscience

Author Information

  1. Weiping Han,
  2. Danqing Li,
  3. Amy K. Stout,
  4. Koichi Takimoto, and
  5. Edwin S. Levitan
  1. 1Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
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Author contributions

Disclosures

    • Received October 8, 1998.
    • Revision received November 10, 1998.
    • Accepted November 16, 1998.
  • This study was supported by National Institutes of Health Grant NS32385 and an Established Investigator Award from the American Heart Association to E.S.L. We thank Dr. Nancy A. Burke for her help with radioimmunoassay experiments.

    Correspondence should be addressed to Dr. Edwin S. Levitan, Department of Pharmacology, E1351 Biomedical Science Tower, University of Pittsburgh, Pittsburgh, PA 15261.

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The Journal of Neuroscience: 19 (3)
Journal of Neuroscience
Vol. 19, Issue 3
1 Feb 1999
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Ca2+-Induced Deprotonation of Peptide Hormones Inside Secretory Vesicles in Preparation for Release
Weiping Han, Danqing Li, Amy K. Stout, Koichi Takimoto, Edwin S. Levitan
Journal of Neuroscience 1 February 1999, 19 (3) 900-905; DOI: 10.1523/JNEUROSCI.19-03-00900.1999

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Ca2+-Induced Deprotonation of Peptide Hormones Inside Secretory Vesicles in Preparation for Release
Weiping Han, Danqing Li, Amy K. Stout, Koichi Takimoto, Edwin S. Levitan
Journal of Neuroscience 1 February 1999, 19 (3) 900-905; DOI: 10.1523/JNEUROSCI.19-03-00900.1999
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Keywords

  • GFP
  • peptide hormone
  • exocytosis
  • alkalinization
  • secretory vesicle
  • Ca2+

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