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ARTICLE

Functional Properties of Two Bombesin-Like Peptide Receptors Revealed by the Analysis of Mice Lacking Neuromedin B Receptor

Hiroko Ohki-Hamazaki, Yasushi Sakai, Katsuo Kamata, Hiroo Ogura, Shigeru Okuyama, Kei Watase, Kazuyuki Yamada and Keiji Wada
Journal of Neuroscience 1 February 1999, 19 (3) 948-954; https://doi.org/10.1523/JNEUROSCI.19-03-00948.1999
Hiroko Ohki-Hamazaki
1Department of Neurochemistry, Tokyo Institute of Psychiatry, Setagaya-ku, Tokyo 156-8585, Japan,
2Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan,
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Yasushi Sakai
3Laboratory of Physiology, Department of Occupational Therapy, College of Medical Sciences, Showa University, Midori-ku, Yokohama, Kanagawa 226-8555, Japan,
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Katsuo Kamata
4Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa-ku, Tokyo 142-0063, Japan,
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Hiroo Ogura
5Tsukuba Research Laboratories, Eisai Company, Tsukuba, Ibaraki 300-2635, Japan, and
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Shigeru Okuyama
61st Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical Company, Ohmiya, Saitama 330-8530, Japan
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Kei Watase
2Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan,
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Kazuyuki Yamada
2Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan,
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Keiji Wada
2Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan,
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Abstract

The neuromedin B-preferring receptor (NMB-R) is one of the members of the bombesin (BN)-like peptide receptor subfamily in mammals. Previously, we have generated and characterized mice with targeted disruption of the two other BN-like peptide receptors, bombesin receptor subtype-3 (BRS-3) and gastrin-releasing peptide-preferring receptor (GRP-R). Here we describe the generation and analysis of NMB-R-deficient mice to investigate how NMB-R differs from BRS-3 and GRP-R. Compensation for NMB-R deficiency by overexpression of GRP-R and/or BRS-3 was not detected. Although the hypothermic effect of NMB was reduced by 50% in NMB-R-deficient mice, the effect of GRP infusion was comparable to the wild-type mice. In contrast, fundic smooth muscle contraction on stimulation with NMB or GRP was normal in NMB-R-deficient mice. Administration of GRP but not NMB suppressed glucose intake in both normal and NMB-R-deficient mice. These results suggest that the NMB-R has an essential role in thermoregulation, but not for smooth muscle contraction of the fundus or for the suppression of feeding behavior. In addition, the behavioral phenotypes of GRP-R-deficient mice were not observed in NMB-R-deficient mice. These data show that the functions of NMB-R and GRP-R are distinct, with only partial overlap.

  • neuromedin B receptor
  • gastrin-releasing peptide receptor
  • smooth muscle contraction
  • thermoregulation
  • feeding suppression
  • social behavior
  • knock-out mice
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The Journal of Neuroscience: 19 (3)
Journal of Neuroscience
Vol. 19, Issue 3
1 Feb 1999
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Functional Properties of Two Bombesin-Like Peptide Receptors Revealed by the Analysis of Mice Lacking Neuromedin B Receptor
Hiroko Ohki-Hamazaki, Yasushi Sakai, Katsuo Kamata, Hiroo Ogura, Shigeru Okuyama, Kei Watase, Kazuyuki Yamada, Keiji Wada
Journal of Neuroscience 1 February 1999, 19 (3) 948-954; DOI: 10.1523/JNEUROSCI.19-03-00948.1999

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Functional Properties of Two Bombesin-Like Peptide Receptors Revealed by the Analysis of Mice Lacking Neuromedin B Receptor
Hiroko Ohki-Hamazaki, Yasushi Sakai, Katsuo Kamata, Hiroo Ogura, Shigeru Okuyama, Kei Watase, Kazuyuki Yamada, Keiji Wada
Journal of Neuroscience 1 February 1999, 19 (3) 948-954; DOI: 10.1523/JNEUROSCI.19-03-00948.1999
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Keywords

  • neuromedin B receptor
  • gastrin-releasing peptide receptor
  • smooth muscle contraction
  • thermoregulation
  • feeding suppression
  • social behavior
  • knock-out mice

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