The 69 bp Circadian Regulatory Sequence (CRS) Mediatesper-Like Developmental, Spatial, and Circadian Expression and Behavioral Rescue in Drosophila

Haiping Hao; Nick R. J. Glossop; Lisa Lyons; Jan Qiu; Bronwyn Morrish; Yuzhong Cheng; Charlotte Helfrich-Förster; Paul Hardin

doi:10.1523/JNEUROSCI.19-03-00987.1999

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.19-03-00987.1999

PubMed

9920662

Published By

Society for Neuroscience

History

Received June 1, 1998
Revision received November 4, 1998
Accepted November 6, 1998
First published February 1, 1999.

Version of record published February 1, 1999.

Author Information

Haiping Hao1,2,3,
Nick R. J. Glossop1,
Lisa Lyons1,
Jan Qiu1,2,4,
Bronwyn Morrish1,5,
Yuzhong Cheng1,2,6,
Charlotte Helfrich-Förster7, and
Paul Hardin1

¹Department of Biology, University of Houston, Houston, Texas 77204-5513,
²Department of Biology, Texas A & M University, College Station, Texas 77843-3258,
³Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520-8081,
⁴Department of Biology, Brandeis University, Waltham, Massachusetts 02254,
⁵Department of Biology, University of York, Heslington YO1 5DD, United Kingdom,
⁶Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, and
⁷Institute of Zoology, Animal Physiology, University of Tübingen, Tübingen 72076, Germany

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Author contributions

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Disclosures

Received June 1, 1998.
Revision received November 4, 1998.
Accepted November 6, 1998.

This study was supported by National Institutes of Health Grant NS31214. We thank Ralf Stanewsky for providing anti-PER antibody, Isaac Edery for providing the hspcper DNA construct, and Jeff Hall for providing the BG6 transformant line. We also thank Cai Wu and Jerry Houl for behavioral analysis and Jerry Houl for his assistance with experiments. We thank Balaji Krishnan for comments on this manuscript.
Correspondence should be addressed to Dr. Paul Hardin, Department of Biology, University of Houston, Houston, TX 77204-5513.

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	Abstract	Full	Pdf
Jan 1999	72	71	48
Feb 1999	39	83	56
Mar 1999	8	30	22
Dec 1999	3	11	7
Total 1999	122	195	133
Jan 2000	6	14	10
Feb 2000	3	13	4
Mar 2000	3	9	2
Apr 2000	5	14	6
May 2000	5	18	10
Jun 2000	1	5	0
Jul 2000	0	3	2
Aug 2000	0	4	4
Sep 2000	2	6	2
Oct 2000	6	4	5
Nov 2000	2	5	2
Dec 2000	3	7	6
Total 2000	36	102	53
Jan 2001	3	13	5
Feb 2001	1	4	3
Mar 2001	2	8	6
Apr 2001	2	8	5
May 2001	2	10	12
Jun 2001	2	7	11
Jul 2001	2	6	4
Sep 2001	0	1	0
Oct 2001	1	9	5
Nov 2001	2	3	2
Dec 2001	0	2	2
Total 2001	17	71	55
Jan 2002	1	15	13
Feb 2002	0	5	4
Mar 2002	0	4	4
Apr 2002	0	4	2
May 2002	0	3	4
Jun 2002	0	3	3
Jul 2002	0	5	3
Aug 2002	1	0	0
Sep 2002	0	2	3
Oct 2002	2	6	8
Nov 2002	1	3	7
Dec 2002	0	9	4
Total 2002	5	59	55
Jan 2003	0	3	2
Feb 2003	2	12	6
Mar 2003	3	3	2
Apr 2003	0	1	1
May 2003	3	6	7
Jun 2003	0	13	8
Jul 2003	4	9	4
Aug 2003	4	13	5
Sep 2003	7	19	3
Oct 2003	15	14	5
Nov 2003	13	19	15
Dec 2003	13	19	2
Total 2003	64	131	60
Jan 2004	14	11	8
Feb 2004	10	9	4
Mar 2004	16	16	4
Apr 2004	12	22	15
May 2004	14	23	8
Jun 2004	9	14	1
Jul 2004	18	24	7
Aug 2004	33	34	7
Sep 2004	31	19	7
Oct 2004	12	17	8
Nov 2004	21	19	5
Dec 2004	20	14	5
Total 2004	210	222	79
Jan 2005	23	18	2
Feb 2005	17	16	4
Mar 2005	21	16	3
Apr 2005	7	10	4
May 2005	4	21	9
Jun 2005	11	16	3
Jul 2005	3	12	4
Aug 2005	10	7	4
Sep 2005	2	5	2
Oct 2005	8	14	4
Nov 2005	11	17	1
Dec 2005	3	12	2
Total 2005	120	164	42
Jan 2006	2	11	4
Feb 2006	4	11	8
Mar 2006	4	14	8
Apr 2006	1	7	2
May 2006	5	6	8
Jun 2006	5	9	8
Jul 2006	2	8	5
Aug 2006	5	0	0
Sep 2006	4	9	3
Oct 2006	1	7	4
Nov 2006	1	10	11
Dec 2006	5	8	8
Total 2006	39	100	69
Jan 2007	2	8	7
Feb 2007	3	10	4
Mar 2007	4	11	6
Apr 2007	2	9	8
May 2007	4	11	11
Jun 2007	4	5	0
Jul 2007	3	2	5
Aug 2007	1	10	8
Sep 2007	4	6	4
Oct 2007	1	5	1
Nov 2007	6	6	5
Dec 2007	5	7	7
Total 2007	39	90	66
Jan 2008	1	6	9
Feb 2008	5	4	6
Mar 2008	7	8	12
Apr 2008	2	2	4
May 2008	2	3	3
Jun 2008	8	15	9
Jul 2008	4	11	10
Aug 2008	7	12	3
Sep 2008	6	7	5
Oct 2008	7	7	3
Nov 2008	3	8	6
Dec 2008	5	7	4
Total 2008	57	90	74
Jan 2009	5	6	6
Feb 2009	4	8	5
Mar 2009	3	5	4
Apr 2009	1	42	5
May 2009	4	4	5
Jun 2009	0	6	5
Jul 2009	4	4	3
Aug 2009	18	5	7
Sep 2009	3	23	1
Oct 2009	2	7	6
Nov 2009	4	11	5
Dec 2009	6	7	4
Total 2009	54	128	56
Jan 2010	4	3	4
Feb 2010	4	5	5
Mar 2010	9	6	4
Apr 2010	9	5	7
May 2010	0	1	5
Jun 2010	2	1	2
Jul 2010	1	19	1
Aug 2010	5	3	1
Sep 2010	4	5	2
Oct 2010	6	12	3
Nov 2010	5	9	3
Dec 2010	4	4	2
Total 2010	53	73	39
Jan 2011	5	8	10
Feb 2011	3	4	3
Mar 2011	3	7	9
Apr 2011	2	5	4
May 2011	7	9	9
Jun 2011	3	7	12
Jul 2011	8	2	2
Aug 2011	4	1	3
Sep 2011	7	2	7
Oct 2011	4	1	1
Nov 2011	6	5	9
Dec 2011	7	2	1
Total 2011	59	53	70
Jan 2012	5	7	10
Feb 2012	3	3	6
Mar 2012	9	6	9
Apr 2012	3	5	11
May 2012	4	4	9
Jun 2012	6	4	4
Jul 2012	2	1	3
Aug 2012	5	4	5
Sep 2012	1	1	4
Oct 2012	10	4	4
Nov 2012	16	4	3
Dec 2012	22	4	7
Total 2012	86	47	75
Jan 2013	12	2	8
Feb 2013	6	8	4
Mar 2013	3	4	9
Apr 2013	2	1	8
May 2013	2	2	6
Jun 2013	1	3	6
Jul 2013	2	1	3
Aug 2013	2	1	5
Sep 2013	3	0	7
Oct 2013	9	7	8
Nov 2013	6	10	17
Dec 2013	4	29	62
Total 2013	52	68	143
Jan 2014	6	21	21
Feb 2014	5	81	34
Mar 2014	3	13	16
Apr 2014	10	2	10
May 2014	6	7	22
Jun 2014	5	6	9
Jul 2014	3	10	10
Aug 2014	2	14	21
Sep 2014	1	13	20
Oct 2014	8	12	18
Nov 2014	1	7	6
Dec 2014	4	8	15
Total 2014	54	194	202
Jan 2015	0	2	3
Feb 2015	4	5	3
Mar 2015	2	3	3
Apr 2015	4	1	1
May 2015	0	4	3
Jun 2015	4	3	3
Jul 2015	3	4	3
Aug 2015	6	7	3
Sep 2015	3	1	5
Oct 2015	0	1	3
Nov 2015	3	1	0
Dec 2015	6	6	9
Total 2015	35	38	39
Jan 2016	2	0	5
Feb 2016	4	6	4
Mar 2016	6	6	10
Apr 2016	0	7	4
May 2016	1	6	4
Jun 2016	2	4	3
Jul 2016	4	4	6
Aug 2016	1	3	2
Sep 2016	3	0	2
Oct 2016	1	6	5
Nov 2016	0	2	3
Dec 2016	0	5	2
Total 2016	24	49	50
Jan 2017	30	4	3
Feb 2017	77	5	2
Mar 2017	99	15	5
Apr 2017	28	2	5
May 2017	7	24	1
Jun 2017	3	8	6
Jul 2017	1	5	0
Aug 2017	6	6	4
Sep 2017	13	0	1
Oct 2017	22	3	5
Nov 2017	51	12	5
Dec 2017	45	8	3
Total 2017	382	92	40
Jan 2018	36	13	5
Feb 2018	24	7	2
Mar 2018	6	12	1
Apr 2018	0	18	4
May 2018	1	15	1
Jun 2018	2	25	2
Jul 2018	1	18	4
Aug 2018	1	48	3
Sep 2018	13	45	4
Oct 2018	1	38	3
Nov 2018	2	46	2
Dec 2018	3	21	3
Total 2018	90	306	34
Jan 2019	1	17	0
Feb 2019	8	14	2
Mar 2019	2	23	4
Apr 2019	40	13	3
May 2019	15	42	2
Jun 2019	3	56	5
Jul 2019	4	80	6
Aug 2019	1	134	3
Sep 2019	2	51	5
Oct 2019	11	75	2
Nov 2019	21	53	10
Dec 2019	4	16	1
Total 2019	112	574	43
Jan 2020	5	19	2
Feb 2020	0	32	3
Mar 2020	0	29	4
Apr 2020	0	17	1
May 2020	0	24	2
Jun 2020	2	26	4
Jul 2020	1	24	0
Aug 2020	0	16	2
Sep 2020	3	37	5
Oct 2020	3	36	7
Nov 2020	3	28	4
Dec 2020	4	27	3
Total 2020	21	315	37
Jan 2021	2	16	13
Total 2021	2	16	13
Total	1733	3177	1527