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ARTICLE

Effect of Chronic High-Dose Exogenous Cortisol on Hippocampal Neuronal Number in Aged Nonhuman Primates

James B. Leverenz, Charles W. Wilkinson, Molly Wamble, Shannon Corbin, Jo Ellen Grabber, Murray A. Raskind and Elaine R. Peskind
Journal of Neuroscience 15 March 1999, 19 (6) 2356-2361; DOI: https://doi.org/10.1523/JNEUROSCI.19-06-02356.1999
James B. Leverenz
1Veterans Affairs Puget Sound Health Care System,Mental Illness Research, Education, and Clinical Center and
3Neurology and
4Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington 98195, and
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Charles W. Wilkinson
2Geriatric Research, Education, and Clinical Center, Seattle, Washington 98108, and Departments of
4Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington 98195, and
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Molly Wamble
1Veterans Affairs Puget Sound Health Care System,Mental Illness Research, Education, and Clinical Center and
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Shannon Corbin
1Veterans Affairs Puget Sound Health Care System,Mental Illness Research, Education, and Clinical Center and
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Jo Ellen Grabber
5Washington Regional Primate Research Center, Seattle, Washington 98195
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Murray A. Raskind
1Veterans Affairs Puget Sound Health Care System,Mental Illness Research, Education, and Clinical Center and
4Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington 98195, and
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Elaine R. Peskind
1Veterans Affairs Puget Sound Health Care System,Mental Illness Research, Education, and Clinical Center and
4Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington 98195, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.19-06-02356.1999
PubMed 
10066285
Published By 
Society for Neuroscience
History 
  • Received July 10, 1998
  • Revision received December 1, 1998
  • Accepted January 5, 1999
  • First published March 15, 1999.
  • Version of record published March 15, 1999.
Copyright & Usage 
Copyright © 1999 Society for Neuroscience

Author Information

  1. James B. Leverenz1,3,4,
  2. Charles W. Wilkinson2,4,
  3. Molly Wamble1,
  4. Shannon Corbin1,
  5. Jo Ellen Grabber5,
  6. Murray A. Raskind1,4, and
  7. Elaine R. Peskind1,4
  1. 1Veterans Affairs Puget Sound Health Care System,Mental Illness Research, Education, and Clinical Center and
  2. 2Geriatric Research, Education, and Clinical Center, Seattle, Washington 98108, and Departments of
  3. 3Neurology and
  4. 4Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington 98195, and
  5. 5Washington Regional Primate Research Center, Seattle, Washington 98195
View Full Text

Author contributions

Disclosures

    • Received July 10, 1998.
    • Revision received December 1, 1998.
    • Accepted January 5, 1999.
  • This work was supported by National Institutes of Health Grant 2P51RR00166, National Institute on Aging Grant AGO6136, the Alzheimer’s Association, and the Department of Veterans Affairs. We gratefully acknowledge the assistance of Bradley T. Hyman and T. Gomez-Isla with the stereological methods, the assistance of William R. Morton as Director of the Washington Regional Primate Research Center, and the tireless technical assistance of Lynne Greenup, Elizabeth Colasurdo, Richard Vertz, Judy Johnson, and Mark Murchison.

    Correspondence should be addressed to Dr. Elaine R. Peskind, Veterans Affairs Puget Sound Health Care System, Mental Illness Research, Education and Clinical Center (116 MIRECC), 1660 South Columbian Way, Seattle, WA 98108.

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The Journal of Neuroscience: 19 (6)
Journal of Neuroscience
Vol. 19, Issue 6
15 Mar 1999
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Effect of Chronic High-Dose Exogenous Cortisol on Hippocampal Neuronal Number in Aged Nonhuman Primates
James B. Leverenz, Charles W. Wilkinson, Molly Wamble, Shannon Corbin, Jo Ellen Grabber, Murray A. Raskind, Elaine R. Peskind
Journal of Neuroscience 15 March 1999, 19 (6) 2356-2361; DOI: 10.1523/JNEUROSCI.19-06-02356.1999

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Effect of Chronic High-Dose Exogenous Cortisol on Hippocampal Neuronal Number in Aged Nonhuman Primates
James B. Leverenz, Charles W. Wilkinson, Molly Wamble, Shannon Corbin, Jo Ellen Grabber, Murray A. Raskind, Elaine R. Peskind
Journal of Neuroscience 15 March 1999, 19 (6) 2356-2361; DOI: 10.1523/JNEUROSCI.19-06-02356.1999
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Keywords

  • cortisol
  • aging
  • nonhuman primate
  • hippocampus
  • stereology
  • CSF cortisol

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