Article Figures & Data
Figures
- Fig. 1.
Representative coronal sections from rostral to caudal hippocampus (A, C,E, G) and outlines of dentate granule cell layer, hilus, CA2/3, CA1, and subiculum as used in stereological cell counting (B, D, F,H). CA1′ (Rosene and Van Hoesen, 1987) was not included within the assessed CA1 subfield.
- Fig. 2.
Twenty-four hour urinary cortisol concentrations (expressed as nanomoles per millimoles creatinine) in placebo- and cortisol-treated groups at baseline (BL), after 2 weeks (wk), and after 3, 6, 9, and 12 months (m) of treatment. *p < 0.05, higher than baseline; †p < 0.01, higher than placebo group.
- Fig. 3.
Plasma ACTH concentrations (expressed as picomoles per liter) in placebo- and cortisol-treated groups at baseline (BL), after 2 weeks (wk), and after 3, 6, 9, and 12 months (m) of treatment. *p < 0.01, lower than baseline; †p < 0.05, lower than placebo group.
- Fig. 4.
CSF cortisol concentrations (expressed as nanomoles per liter) in placebo- and cortisol-treated groups after 12 months of treatment obtained by lumbar or cisternal puncture in sedated animals before death. *p < 0.01, higher in placebo group.
Tables
Placebo Cortisol p value* Subiculum Volume 29.4 ± 2.6 25.5 ± 1.4 0.12 Density 7165.9 ± 377.4 7851.1 ± 504.7 0.86 Cell # 208,299 ± 15,346 195,969 ± 9772 0.26 CA1 Volume 67.7 ± 4.1 71.7 ± 2.7 0.78 Density 10,281.6 ± 345.3 10,183.9 ± 332.5 0.42 Cell # 694,803 ± 46,471 726,092 ± 16,805 0.72 CA2/3 Volume 37.9 ± 2.2 40.6 ± 2.7 0.78 Density 8736.3 ± 374.2 8797.4 ± 276.9 0.55 Cell # 329,104 ± 18,289 358,868 ± 29,680 0.80 Hilus Volume 49.5 ± 4.1 52.1 ± 3.2 0.68 Density 5331.6 ± 127.0 5060.1 ± 163.6 0.10 Cell # 262,668 ± 20,166 264,355 ± 20,534 0.52 Dentate Volume 13.2 ± 0.8 14.4 ± 1.0 0.81 Density 167,937.6 ± 8841.6 172,272 ± 5777.4 0.65 Cell # 2,216,385 ± 173,760 2,460,120 ± 141,029 0.84 *Student’s t test, unpaired, one-tailed.
