Erratum:On the third page of the table of contents in the February 15, 1999 issue, the page numbers were incorrect for the articles by Cartmell et al., Pettorossi et al., and Rolls et al. and were not given in the legend to the cover picture. The page of the contents is reprinted.
Cover picture: Confocal micrographs showing the localization of the AMPA receptor subunit GluR1 (red) compared with the synaptic marker SV2 (green) in control (top) and AMPA-pretreated (bottom) cultured hippocampal neurons. Within 15 min after application, AMPA (100 μm) caused GluR1 subunits to redistribute away from synaptic sites. This redistribution is indicated in the displayed micrographs by reduced GluR1 immunoreactivity associated with SV2-positive structures and a concomitant accumulation of GluR1 immunoreactivity in nonsynaptic regions and the cytoplasm of AMPA-pretreated cells (shown at higher magnification in theinsets). Inhibition of miniature EPSCs measured in AMPA-pretreated cultures after washout, displayed in the overlayed electrophysiological tracings, suggests that the rapid redistribution of GluR1 subunits plays a functional role in regulating synaptic transmission. For details, see the article by Lissin et al., in this issue (pages 1263–1272). Illustration courtesy of Heather Deacon.
