Skip to main content

Umbrella menu

  • SfN.org
  • eNeuro
  • The Journal of Neuroscience
  • Neuronline
  • BrainFacts.org

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
  • ALERTS
  • FOR AUTHORS
    • Preparing a Manuscript
    • Submission Guidelines
    • Fees
    • Journal Club
    • eLetters
    • Submit
  • EDITORIAL BOARD
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
  • SUBSCRIBE
  • SfN.org
  • eNeuro
  • The Journal of Neuroscience
  • Neuronline
  • BrainFacts.org

User menu

  • Log in
  • Subscribe
  • My alerts
  • My Cart

Search

  • Advanced search
Journal of Neuroscience
  • Log in
  • Subscribe
  • My alerts
  • My Cart
Journal of Neuroscience

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
  • ALERTS
  • FOR AUTHORS
    • Preparing a Manuscript
    • Submission Guidelines
    • Fees
    • Journal Club
    • eLetters
    • Submit
  • EDITORIAL BOARD
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
  • SUBSCRIBE
PreviousNext
ARTICLE

Functional Analysis of a Mouse Brain Elk-Type K+Channel

Matthew C. Trudeau, Steven A. Titus, Janet L. Branchaw, Barry Ganetzky and Gail A. Robertson
Journal of Neuroscience 15 April 1999, 19 (8) 2906-2918; DOI: https://doi.org/10.1523/JNEUROSCI.19-08-02906.1999
Matthew C. Trudeau
1Department of Physiology, University of Wisconsin-Madison Medical School, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Steven A. Titus
2Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Janet L. Branchaw
1Department of Physiology, University of Wisconsin-Madison Medical School, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Barry Ganetzky
2Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gail A. Robertson
1Department of Physiology, University of Wisconsin-Madison Medical School, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

Members of the Ether à go-go (Eag) K+channel subfamilies Eag, Erg, and Elk are widely expressed in the nervous system, but their neural functions in vivoremain largely unknown. The biophysical properties of channels from the Eag and Erg subfamilies have been described, and based on their characteristic features and expression patterns, Erg channels have been associated with native currents in the heart. Little is known about the properties of channels from the Elk subfamily. We have identified a mouse gene, Melk2, that encodes a predicted polypeptide with 48% amino acid identity to Drosophila Elk but only 40 and 36% identity with mouse Erg (Merg) and Eag (Meag), respectively. Melk2 RNA appears to be expressed at high levels only in brain tissue. Functional expression ofMelk2 in Xenopus oocytes reveals large, transient peaks of current at the onset of depolarization. Like Meag currents, Melk2 currents activate relatively quickly, but they lack the nonsuperimposable Cole–Moore shift characteristic of the Eag subfamily. Melk2 currents are insensitive to E-4031, a class III antiarrhythmic compound that blocks the Human Ether-à-go-go-Related Gene (HERG) channel and its counterpart in native tissues, IKr. Melk2 channels exhibit inward rectification because of a fast C-type inactivation mechanism, but the slower rate of inactivation and the faster rate of activation results in less inward rectification than that observed in HERG channels. This characterization of Melk currents should aid in identification of native counterparts to the Elk subfamily of channels in the nervous system.

  • Melk2
  • Elk
  • Eag
  • brain
  • channel
  • C-type inactivation
View Full Text
Back to top

In this issue

The Journal of Neuroscience: 19 (8)
Journal of Neuroscience
Vol. 19, Issue 8
15 Apr 1999
  • Table of Contents
  • Index by author
Email

Thank you for sharing this Journal of Neuroscience article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Functional Analysis of a Mouse Brain Elk-Type K+Channel
(Your Name) has forwarded a page to you from Journal of Neuroscience
(Your Name) thought you would be interested in this article in Journal of Neuroscience.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Functional Analysis of a Mouse Brain Elk-Type K+Channel
Matthew C. Trudeau, Steven A. Titus, Janet L. Branchaw, Barry Ganetzky, Gail A. Robertson
Journal of Neuroscience 15 April 1999, 19 (8) 2906-2918; DOI: 10.1523/JNEUROSCI.19-08-02906.1999

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Request Permissions
Share
Functional Analysis of a Mouse Brain Elk-Type K+Channel
Matthew C. Trudeau, Steven A. Titus, Janet L. Branchaw, Barry Ganetzky, Gail A. Robertson
Journal of Neuroscience 15 April 1999, 19 (8) 2906-2918; DOI: 10.1523/JNEUROSCI.19-08-02906.1999
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • Melk2
  • ELK
  • EAG
  • brain
  • channel
  • C-type inactivation

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

  • Calcium Influx via L- and N-Type Calcium Channels Activates a Transient Large-Conductance Ca2+-Activated K+Current in Mouse Neocortical Pyramidal Neurons
  • Intracranially Administered Anti-Αβ Antibodies Reduce β-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation
  • Neural Correlates of Competing Fear Behaviors Evoked by an Innately Aversive Stimulus
Show more ARTICLE
  • Home
  • Alerts
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Issue Archive
  • Collections

Information

  • For Authors
  • For Advertisers
  • For the Media
  • For Subscribers

About

  • About the Journal
  • Editorial Board
  • Privacy Policy
  • Contact
  • Feedback
(JNeurosci logo)
(SfN logo)

Copyright © 2021 by the Society for Neuroscience.
JNeurosci Online ISSN: 1529-2401

The ideas and opinions expressed in JNeurosci do not necessarily reflect those of SfN or the JNeurosci Editorial Board. Publication of an advertisement or other product mention in JNeurosci should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in JNeurosci.