ARTICLE

Characterization of Progressive Motor Deficits in Mice Transgenic for the Human Huntington’s Disease Mutation

Rebecca J. Carter, Lisa A. Lione, Trevor Humby, Laura Mangiarini, Amarbirpal Mahal, Gillian P. Bates, Stephen B. Dunnett and A. Jennifer Morton
Journal of Neuroscience 15 April 1999, 19 (8) 3248-3257; https://doi.org/10.1523/JNEUROSCI.19-08-03248.1999

Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.19-08-03248.1999
PubMed 
10191337
Published By 
Society for Neuroscience
History 
  • Received November 13, 1998
  • Revision received January 26, 1999
  • Accepted February 8, 1999
  • First published April 15, 1999.
  • Version of record published April 15, 1999.
Copyright & Usage 
Copyright © 1999 Society for Neuroscience

Author Information

  1. Rebecca J. Carter1,
  2. Lisa A. Lione2,3,
  3. Trevor Humby2,
  4. Laura Mangiarini5,
  5. Amarbirpal Mahal5,
  6. Gillian P. Bates5,
  7. Stephen B. Dunnett2,4, and
  8. A. Jennifer Morton1
  1. 1Department of Pharmacology,
  2. 2Centre for Brain Repair,
  3. 3Parke-Davis Neuroscience Research, and
  4. 4Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 1QJ, United Kingdom, and
  5. 5Division of Medical and Molecular Genetics, Guy’s Hospital, London SE1 9RT, United Kingdom
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Author contributions

Disclosures

    • Received November 13, 1998.
    • Revision received January 26, 1999.
    • Accepted February 8, 1999.

  • This work was supported by grants from the Hereditary Disease Foundation and the Wellcome Trust (UK). R.J.C. is supported by the Medical Research Council (UK); L.A.L. is supported by Parke-Davis Neuroscience Research (UK). We are grateful to Chris Riches for valuable technical assistance.

    R.J.C. and L.A.L. contributed equally to this work.

    Correspondence should be addressed to Dr. Jenny Morton, Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QJ, UK.

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Characterization of Progressive Motor Deficits in Mice Transgenic for the Human Huntington’s Disease Mutation
Rebecca J. Carter, Lisa A. Lione, Trevor Humby, Laura Mangiarini, Amarbirpal Mahal, Gillian P. Bates, Stephen B. Dunnett, A. Jennifer Morton
Journal of Neuroscience 15 April 1999, 19 (8) 3248-3257; DOI: 10.1523/JNEUROSCI.19-08-03248.1999
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