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ARTICLE, Behavioral/Systems

Chronic Hypersensitivity For Inflammatory Nociceptor Sensitization Mediated by the ε Isozyme of Protein Kinase C

K. O. Aley, Robert O. Messing, Daria Mochly-Rosen and Jon D. Levine
Journal of Neuroscience 15 June 2000, 20 (12) 4680-4685; https://doi.org/10.1523/JNEUROSCI.20-12-04680.2000
K. O. Aley
1National Institutes of Health Pain Center, University of California, San Francisco, San Francisco, California 94143-0440,
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Robert O. Messing
2Ernest Gallo Clinic and Research Center, University of California, Emeryville, California 94608, and
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Daria Mochly-Rosen
3Molecular Pharmacology, Stanford University, Stanford, California 94305
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Jon D. Levine
1National Institutes of Health Pain Center, University of California, San Francisco, San Francisco, California 94143-0440,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.20-12-04680.2000
PubMed 
10844037
Published By 
Society for Neuroscience
History 
  • Received October 28, 1999
  • Revision received February 18, 2000
  • Accepted March 27, 2000
  • First published June 15, 2000.
  • Version of record published June 15, 2000.
Copyright & Usage 
Copyright © 2000 Society for Neuroscience

Author Information

  1. K. O. Aley1,
  2. Robert O. Messing2,
  3. Daria Mochly-Rosen3, and
  4. Jon D. Levine1
  1. 1National Institutes of Health Pain Center, University of California, San Francisco, San Francisco, California 94143-0440,
  2. 2Ernest Gallo Clinic and Research Center, University of California, Emeryville, California 94608, and
  3. 3Molecular Pharmacology, Stanford University, Stanford, California 94305
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Author contributions

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Disclosures

    • Received October 28, 1999.
    • Revision received February 18, 2000.
    • Accepted March 27, 2000.
  • This work was funded by National Institutes of Health Grant NS21647. We acknowledge many helpful discussions with Drs. David Reichling, Philip Heller, and Paul Green.

    Correspondence should be addressed to Dr. K. O. Aley, National Institutes of Health Pain Center, University of California, San Francisco, Box 0440, San Francisco, CA 94143-0440. E-mail:aley{at}itsa.ucsf.edu.

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The Journal of Neuroscience: 20 (12)
Journal of Neuroscience
Vol. 20, Issue 12
15 Jun 2000
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Chronic Hypersensitivity For Inflammatory Nociceptor Sensitization Mediated by the ε Isozyme of Protein Kinase C
K. O. Aley, Robert O. Messing, Daria Mochly-Rosen, Jon D. Levine
Journal of Neuroscience 15 June 2000, 20 (12) 4680-4685; DOI: 10.1523/JNEUROSCI.20-12-04680.2000

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Chronic Hypersensitivity For Inflammatory Nociceptor Sensitization Mediated by the ε Isozyme of Protein Kinase C
K. O. Aley, Robert O. Messing, Daria Mochly-Rosen, Jon D. Levine
Journal of Neuroscience 15 June 2000, 20 (12) 4680-4685; DOI: 10.1523/JNEUROSCI.20-12-04680.2000
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Keywords

  • carrageenan
  • chronic pain
  • inflammation
  • prostaglandin E2
  • protein kinase Cε
  • second messenger

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