Rectification and Rapid Activation at Low Ca2+ of Ca2+-Activated, Voltage-Dependent BK Currents: Consequences of Rapid Inactivation by a Novel β Subunit

Xiao-Ming Xia; Jiu-Ping Ding; Xu-Hui Zeng; Kai-Lai Duan; Christopher J. Lingle

doi:10.1523/JNEUROSCI.20-13-04890.2000

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.20-13-04890.2000

PubMed

10864947

Published By

Society for Neuroscience

History

Received February 23, 2000
Revision received April 10, 2000
Accepted April 24, 2000
First published July 1, 2000.

Version of record published July 1, 2000.

Author Information

Xiao-Ming Xia,
Jiu-Ping Ding,
Xu-Hui Zeng,
Kai-Lai Duan, and
Christopher J. Lingle

¹Washington University School of Medicine, Departments of Anesthesiology, and Anatomy and Neurobiology, St. Louis, Missouri 63110

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Author contributions

Disclosures

Received February 23, 2000.
Revision received April 10, 2000.
Accepted April 24, 2000.

This work was supported by National Institutes of Health Grant DK46564 to C.L. We thank Anne Benz and the C. Zorumski laboratory for providing us with oocytes and Jamie Thorp for technical assistance. We thank Ying-Wei Wang for results obtained with β2-Δ33 shown in Figure6D.
Correspondence should be addressed to Chris Lingle, Washington University School of Medicine, Department of Anesthesiology, Box 8054, St. Louis, MO 63110. E-mail: clingle{at}morpheus.wustl.edu.
Dr. Duan's present address: University of Science and Technology of China, School of Life Science, Department of Neurobiology and Biophysics, Hefei, Anhui 230027, China.

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	Abstract	Full	Pdf
Jun 2000	120	115	105
Jul 2000	25	70	47
Aug 2000	17	63	39
Sep 2000	12	25	18
Oct 2000	5	32	27
Nov 2000	4	20	15
Dec 2000	4	37	13
Total 2000	187	362	264
Jan 2001	4	23	16
Feb 2001	2	47	12
Mar 2001	3	40	22
Apr 2001	9	32	17
May 2001	4	24	10
Jun 2001	1	12	11
Jul 2001	2	16	10
Aug 2001	4	20	18
Sep 2001	1	10	6
Oct 2001	2	19	12
Nov 2001	0	12	6
Dec 2001	2	24	14
Total 2001	34	279	154
Jan 2002	1	12	11
Feb 2002	0	42	9
Mar 2002	2	23	15
Apr 2002	3	11	15
May 2002	5	11	8
Jun 2002	1	12	11
Jul 2002	5	16	9
Aug 2002	2	12	9
Sep 2002	1	15	16
Oct 2002	2	15	8
Nov 2002	3	16	6
Dec 2002	2	14	9
Total 2002	27	199	126
Jan 2003	0	12	8
Feb 2003	2	15	7
Mar 2003	0	9	10
Apr 2003	0	14	10
May 2003	3	8	15
Jun 2003	7	17	21
Jul 2003	7	21	8
Aug 2003	11	20	13
Sep 2003	10	17	9
Oct 2003	14	28	9
Nov 2003	13	39	17
Dec 2003	15	24	11
Total 2003	82	224	138
Jan 2004	21	25	5
Feb 2004	15	30	15
Mar 2004	16	22	14
Apr 2004	17	29	20
May 2004	13	29	11
Jun 2004	13	26	21
Jul 2004	12	21	4
Aug 2004	34	37	4
Sep 2004	31	38	11
Oct 2004	18	34	5
Nov 2004	7	18	6
Dec 2004	11	31	5
Total 2004	208	340	121
Jan 2005	23	16	5
Feb 2005	17	19	13
Mar 2005	17	21	14
Apr 2005	5	22	7
May 2005	3	18	10
Jun 2005	11	19	7
Jul 2005	8	14	8
Aug 2005	5	22	11
Sep 2005	7	27	3
Oct 2005	12	16	7
Nov 2005	8	22	15
Dec 2005	8	24	21
Total 2005	124	240	121
Jan 2006	5	19	13
Feb 2006	3	20	8
Mar 2006	1	17	6
Apr 2006	4	20	12
May 2006	4	13	6
Jun 2006	4	24	11
Jul 2006	9	12	5
Aug 2006	4	12	10
Sep 2006	2	6	10
Oct 2006	2	11	6
Nov 2006	2	8	9
Dec 2006	1	16	9
Total 2006	41	178	105
Jan 2007	4	18	7
Feb 2007	3	11	10
Mar 2007	7	24	10
Apr 2007	3	16	7
May 2007	5	13	5
Jun 2007	2	14	6
Jul 2007	1	8	5
Aug 2007	4	7	12
Sep 2007	1	12	4
Oct 2007	8	30	16
Nov 2007	1	16	5
Dec 2007	0	11	8
Total 2007	39	180	95
Jan 2008	3	5	5
Feb 2008	3	6	2
Mar 2008	7	3	5
Apr 2008	8	15	6
May 2008	9	12	11
Jun 2008	3	8	4
Jul 2008	5	3	4
Aug 2008	9	11	5
Sep 2008	13	5	5
Oct 2008	11	9	5
Nov 2008	7	13	2
Dec 2008	7	9	7
Total 2008	85	99	61
Jan 2009	7	9	7
Feb 2009	10	16	1
Mar 2009	18	12	6
Apr 2009	6	9	5
May 2009	5	10	8
Jun 2009	4	13	2
Jul 2009	7	12	3
Aug 2009	2	8	3
Sep 2009	5	10	9
Oct 2009	2	4	10
Nov 2009	7	4	4
Dec 2009	3	4	3
Total 2009	76	111	61
Jan 2010	5	3	5
Feb 2010	1	9	3
Mar 2010	9	11	8
Apr 2010	2	11	11
May 2010	5	9	5
Jun 2010	3	7	2
Jul 2010	3	20	4
Aug 2010	3	6	3
Sep 2010	2	9	6
Oct 2010	4	8	9
Nov 2010	8	13	6
Dec 2010	2	4	3
Total 2010	47	110	65
Jan 2011	9	6	5
Feb 2011	7	8	10
Mar 2011	10	14	10
Apr 2011	8	15	10
May 2011	7	15	10
Jun 2011	2	7	8
Jul 2011	4	10	8
Aug 2011	8	5	4
Sep 2011	5	3	8
Oct 2011	7	10	8
Nov 2011	8	10	11
Dec 2011	9	9	7
Total 2011	84	112	99
Jan 2012	9	15	15
Feb 2012	4	6	6
Mar 2012	7	6	6
Apr 2012	12	6	5
May 2012	15	7	5
Jun 2012	9	4	6
Jul 2012	10	5	2
Aug 2012	8	6	7
Sep 2012	5	1	3
Oct 2012	16	9	12
Nov 2012	19	9	11
Dec 2012	27	5	2
Total 2012	141	79	80
Jan 2013	23	9	12
Feb 2013	10	12	2
Mar 2013	13	5	7
Apr 2013	8	16	8
May 2013	14	7	6
Jun 2013	11	2	6
Jul 2013	9	5	8
Aug 2013	3	3	4
Sep 2013	4	4	4
Oct 2013	16	6	7
Nov 2013	8	7	3
Dec 2013	11	3	8
Total 2013	130	79	75
Jan 2014	8	4	9
Feb 2014	5	5	8
Mar 2014	8	4	6
Apr 2014	8	3	1
May 2014	43	13	10
Jun 2014	24	7	7
Jul 2014	35	17	4
Aug 2014	9	2	3
Sep 2014	16	14	8
Oct 2014	5	7	10
Nov 2014	8	12	11
Dec 2014	8	7	5
Total 2014	177	95	82
Jan 2015	11	5	3
Feb 2015	9	6	2
Mar 2015	8	7	5
Apr 2015	5	43	3
May 2015	6	5	3
Jun 2015	10	3	6
Jul 2015	9	6	4
Aug 2015	15	6	4
Sep 2015	16	4	5
Oct 2015	5	6	4
Nov 2015	4	10	4
Dec 2015	14	10	2
Total 2015	112	111	45
Jan 2016	14	7	4
Feb 2016	19	8	6
Mar 2016	18	3	8
Apr 2016	9	3	5
May 2016	18	7	7
Jun 2016	7	9	2
Jul 2016	12	14	4
Aug 2016	15	5	4
Sep 2016	20	6	6
Oct 2016	11	9	3
Nov 2016	5	38	4
Dec 2016	1	46	5
Total 2016	149	155	58
Jan 2017	1	43	3
Feb 2017	0	35	2
Mar 2017	1	50	4
Apr 2017	0	51	5
May 2017	0	50	3
Jun 2017	2	17	7
Jul 2017	0	20	5
Aug 2017	0	14	3
Sep 2017	0	5	6
Oct 2017	1	21	5
Nov 2017	0	19	7
Dec 2017	0	3	2
Total 2017	5	328	52
Jan 2018	0	7	2
Feb 2018	3	7	3
Mar 2018	2	18	16
Apr 2018	3	18	7
May 2018	1	25	7
Jun 2018	0	22	6
Jul 2018	1	12	3
Aug 2018	1	19	1
Sep 2018	0	18	3
Oct 2018	0	13	3
Nov 2018	0	23	6
Dec 2018	1	13	4
Total 2018	12	195	61
Jan 2019	3	20	6
Feb 2019	1	15	3
Mar 2019	5	38	8
Apr 2019	0	18	5
May 2019	4	16	6
Jun 2019	8	13	12
Jul 2019	2	5	3
Aug 2019	3	42	6
Sep 2019	1	110	3
Oct 2019	5	252	2
Nov 2019	3	16	7
Dec 2019	2	10	4
Total 2019	37	555	65
Jan 2020	4	24	3
Feb 2020	2	13	1
Mar 2020	1	9	2
Apr 2020	15	18	3
May 2020	4	9	6
Jun 2020	1	9	4
Jul 2020	1	4	4
Aug 2020	4	6	3
Sep 2020	6	23	5
Oct 2020	1	25	7
Nov 2020	1	17	5
Dec 2020	4	16	6
Total 2020	44	173	49
Jan 2021	0	19	4
Feb 2021	5	18	4
Total 2021	5	37	8
Total	1846	4241	1985