In the article “Increased Binding Activity at an Antioxidant-Responsive Element in the Metallothionein-1 Promoter and Rapid Induction of Metallothionein-1 and -2 in Response to Cerebral Ischemia and Reperfusion,” by Menno van Lookeren Campagne, Harold Thibodeaux, Nick van Bruggen, Belinda Cairns, and David G. Lowe, which appeared on pages 5200–5207 of the July 15, 2000 issue, the Y-axis legend was omitted for Figure 2. The correct version of the figure, as well as the legend, is printed here.
Increased expression of MT-1 and -2 mRNA in the ischemic cortex precedes the formation of cerebral edema. A, T2 relaxation time increased in the ipsilateral cerebral cortex by 24 hr and further increased at 72 hr after reperfusion. B,C, mRNA levels of both MT-1 (B) and MT-2 (C) were significantly increased in the ipsilateral (ischemic) cerebral cortex 6 hr after reperfusion and peaked at 24 hr after reperfusion. D, E, In contrast, no significant changes in MT-3 or GAPDH mRNA were found. Values are expressed as the mean ± SD of samples obtained from five to six animals (*, p < 0.05; **, p < 0.01, pairedt test). a.u., Arbitrary units; con, control; T2W, T2-weighted.
