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ARTICLE, Cellular/Molecular

Enhanced Spinal Nociceptin Receptor Expression Develops Morphine Tolerance and Dependence

Hiroshi Ueda, Makoto Inoue, Hiroshi Takeshima and Yoshikazu Iwasawa
Journal of Neuroscience 15 October 2000, 20 (20) 7640-7647; https://doi.org/10.1523/JNEUROSCI.20-20-07640.2000
Hiroshi Ueda
1Department of Molecular Pharmacology and Neuroscience, Nagasaki University School of Pharmaceutical Sciences, Nagasaki 852–8521, Japan,
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Makoto Inoue
1Department of Molecular Pharmacology and Neuroscience, Nagasaki University School of Pharmaceutical Sciences, Nagasaki 852–8521, Japan,
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Hiroshi Takeshima
2Department of Pharmacology, Faculty of Medicine, The University of Tokyo, Tokyo 113–0033, Japan, and
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Yoshikazu Iwasawa
3Banyu Tsukuba Research Institute, 3 Okubo Tsukuba, 300–2611, Japan
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.20-20-07640.2000
PubMed 
11027224
Published By 
Society for Neuroscience
History 
  • Received May 15, 2000
  • Revision received July 17, 2000
  • Accepted August 3, 2000
  • First published October 15, 2000.
  • Version of record published October 15, 2000.
Copyright & Usage 
Copyright © 2000 Society for Neuroscience

Author Information

  1. Hiroshi Ueda1,
  2. Makoto Inoue1,
  3. Hiroshi Takeshima2, and
  4. Yoshikazu Iwasawa3
  1. 1Department of Molecular Pharmacology and Neuroscience, Nagasaki University School of Pharmaceutical Sciences, Nagasaki 852–8521, Japan,
  2. 2Department of Pharmacology, Faculty of Medicine, The University of Tokyo, Tokyo 113–0033, Japan, and
  3. 3Banyu Tsukuba Research Institute, 3 Okubo Tsukuba, 300–2611, Japan
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Author contributions

Disclosures

    • Received May 15, 2000.
    • Revision received July 17, 2000.
    • Accepted August 3, 2000.
  • This work was supported in part by Special Coordination funds of the Science and Technology Agency of the Japanese Government, a research grant from the Environmental Agency, Government of Japan, and grants-in-aid from the Ministry of Education, Science, Culture, and Sports of Japan. We thank Leslie Iversen, Alan North, and Carmine Coscia for reading and comments, and Shogo Tokuyama, Taku Yamaguchi, Ichiro Shimohira, Shinobu Matsunaga, Fumiko Fujiwara, and Ye Xun for technical help with RT-PCR and behavioral studies.

    Correspondence should be addressed to Dr. Hiroshi Ueda, Department of Molecular Pharmacology and Neuroscience, Nagasaki University School of Pharmaceutical Sciences, 1–14 Bunkyo-machi, Nagasaki 852–8521, Japan. E-mail: ueda{at}net.nagasaki-u.ac.jp.

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The Journal of Neuroscience: 20 (20)
Journal of Neuroscience
Vol. 20, Issue 20
15 Oct 2000
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Enhanced Spinal Nociceptin Receptor Expression Develops Morphine Tolerance and Dependence
Hiroshi Ueda, Makoto Inoue, Hiroshi Takeshima, Yoshikazu Iwasawa
Journal of Neuroscience 15 October 2000, 20 (20) 7640-7647; DOI: 10.1523/JNEUROSCI.20-20-07640.2000

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Enhanced Spinal Nociceptin Receptor Expression Develops Morphine Tolerance and Dependence
Hiroshi Ueda, Makoto Inoue, Hiroshi Takeshima, Yoshikazu Iwasawa
Journal of Neuroscience 15 October 2000, 20 (20) 7640-7647; DOI: 10.1523/JNEUROSCI.20-20-07640.2000
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Keywords

  • nociceptin/orphanin FQ
  • morphine
  • tolerance
  • dependence
  • plasticity
  • nonpeptidic antagonist

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