Hypocretin-1 Modulates Rapid Eye Movement Sleep through Activation of Locus Coeruleus Neurons

Patrice Bourgin; Salvador Huitrón-Reséndiz; Avron D. Spier; Véronique Fabre; Beatriz Morte; José R. Criado; J. Gregor Sutcliffe; Steven J. Henriksen; Luis de Lecea

doi:10.1523/JNEUROSCI.20-20-07760.2000

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.20-20-07760.2000

PubMed

11027239

Published By

Society for Neuroscience

History

Received February 4, 2000
Revision received July 28, 2000
Accepted July 28, 2000
First published October 15, 2000.

Version of record published October 15, 2000.

Author Information

Patrice Bourgin1,
Salvador Huitrón-Reséndiz2,
Avron D. Spier1,
Véronique Fabre2,
Beatriz Morte1,
José R. Criado2,
J. Gregor Sutcliffe1,
Steven J. Henriksen2, and
Luis de Lecea1,2

¹Departments of Molecular Biology and
²Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037

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Author contributions

Disclosures

Received February 4, 2000.
Revision received July 28, 2000.
Accepted July 28, 2000.

This work was supported by National Institutes of Health Grants MH58543 (L.d.L.), GM32355 (J.G.S.), DA12669 (J.R.C.), and DA08301 (S.J.H.). P.B. was supported by Fondation Simone et Cino del Duca and Fondation Phillippe. B.M. was supported by a fellowship from Comunidad de Madrid. We thank Angels Almenar for help with immunofluorescence and Juliette Hinsche for technical assistance.
Correspondence should be addressed to Dr. Luis de Lecea, Department of Molecular Biology, MB-10, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037. E-mail: llecea{at}scripps.edu.

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	Abstract	Full	Pdf
Oct 2000	317	322	340
Nov 2000	36	112	61
Dec 2000	17	60	28
Total 2000	370	494	429
Jan 2001	11	72	37
Feb 2001	5	39	15
Mar 2001	8	56	31
Apr 2001	9	44	21
May 2001	10	32	24
Jun 2001	4	28	21
Jul 2001	7	30	19
Aug 2001	3	30	13
Sep 2001	2	43	29
Oct 2001	5	20	10
Nov 2001	24	20	13
Dec 2001	3	23	17
Total 2001	91	437	250
Jan 2002	7	42	31
Feb 2002	6	40	23
Mar 2002	2	36	24
Apr 2002	7	34	33
May 2002	4	21	19
Jun 2002	4	20	21
Jul 2002	2	17	20
Aug 2002	3	30	35
Sep 2002	7	22	22
Oct 2002	7	28	23
Nov 2002	2	17	21
Dec 2002	7	33	16
Total 2002	58	340	288
Jan 2003	4	31	17
Feb 2003	3	31	37
Mar 2003	3	22	27
Apr 2003	5	18	25
May 2003	2	30	23
Jun 2003	9	21	19
Jul 2003	30	35	19
Aug 2003	14	27	19
Sep 2003	22	22	14
Oct 2003	80	34	11
Nov 2003	115	37	27
Dec 2003	59	28	18
Total 2003	346	336	256
Jan 2004	27	26	8
Feb 2004	21	45	19
Mar 2004	18	31	18
Apr 2004	16	24	15
May 2004	18	46	13
Jun 2004	17	29	15
Jul 2004	10	24	9
Aug 2004	50	53	17
Sep 2004	45	59	36
Oct 2004	27	41	20
Nov 2004	24	35	15
Dec 2004	23	49	17
Total 2004	296	462	202
Jan 2005	27	43	22
Feb 2005	16	33	23
Mar 2005	34	58	32
Apr 2005	16	30	14
May 2005	13	26	10
Jun 2005	12	25	22
Jul 2005	6	18	14
Aug 2005	17	41	15
Sep 2005	6	21	6
Oct 2005	19	33	16
Nov 2005	27	23	14
Dec 2005	10	27	10
Total 2005	203	378	198
Jan 2006	7	26	17
Feb 2006	11	36	11
Mar 2006	8	37	15
Apr 2006	12	33	16
May 2006	29	36	26
Jun 2006	20	23	11
Jul 2006	19	28	14
Aug 2006	28	33	29
Sep 2006	25	30	20
Oct 2006	19	21	18
Nov 2006	31	18	14
Dec 2006	14	20	14
Total 2006	223	341	205
Jan 2007	20	16	15
Feb 2007	7	17	15
Mar 2007	28	13	10
Apr 2007	22	22	17
May 2007	18	18	21
Jun 2007	8	25	20
Jul 2007	14	14	15
Aug 2007	11	16	14
Sep 2007	12	14	12
Oct 2007	9	33	30
Nov 2007	30	21	22
Dec 2007	8	22	17
Total 2007	187	231	208
Jan 2008	3	11	15
Feb 2008	11	19	18
Mar 2008	13	6	10
Apr 2008	12	28	32
May 2008	29	24	16
Jun 2008	27	29	17
Jul 2008	11	26	12
Aug 2008	10	19	14
Sep 2008	18	11	22
Oct 2008	48	9	15
Nov 2008	30	12	22
Dec 2008	19	12	11
Total 2008	231	206	204
Jan 2009	8	17	17
Feb 2009	18	15	13
Mar 2009	37	18	24
Apr 2009	17	26	19
May 2009	15	20	17
Jun 2009	13	22	22
Jul 2009	13	18	13
Aug 2009	9	10	30
Sep 2009	13	14	16
Oct 2009	10	12	11
Nov 2009	15	15	19
Dec 2009	16	14	18
Total 2009	184	201	219
Jan 2010	9	6	12
Feb 2010	12	10	12
Mar 2010	18	14	13
Apr 2010	17	15	11
May 2010	8	21	20
Jun 2010	12	35	18
Jul 2010	16	23	18
Aug 2010	14	13	12
Sep 2010	13	20	20
Oct 2010	12	22	15
Nov 2010	25	35	18
Dec 2010	10	20	17
Total 2010	166	234	186
Jan 2011	14	23	21
Feb 2011	14	19	28
Mar 2011	33	23	18
Apr 2011	15	17	20
May 2011	13	14	17
Jun 2011	9	17	13
Jul 2011	19	13	13
Aug 2011	31	17	16
Sep 2011	40	20	14
Oct 2011	37	16	15
Nov 2011	32	19	14
Dec 2011	26	23	11
Total 2011	283	221	200
Jan 2012	30	19	7
Feb 2012	40	14	16
Mar 2012	64	39	9
Apr 2012	40	28	22
May 2012	37	19	14
Jun 2012	37	10	9
Jul 2012	16	10	16
Aug 2012	20	16	18
Sep 2012	23	20	10
Oct 2012	38	9	10
Nov 2012	52	9	19
Dec 2012	39	24	11
Total 2012	436	217	161
Jan 2013	38	12	19
Feb 2013	44	10	12
Mar 2013	36	14	12
Apr 2013	38	24	25
May 2013	29	10	19
Jun 2013	37	17	16
Jul 2013	26	10	11
Aug 2013	23	6	14
Sep 2013	18	10	16
Oct 2013	50	13	18
Nov 2013	35	13	15
Dec 2013	43	7	17
Total 2013	417	146	194
Jan 2014	28	21	27
Feb 2014	30	18	17
Mar 2014	27	10	35
Apr 2014	24	19	26
May 2014	39	18	32
Jun 2014	29	45	16
Jul 2014	32	12	11
Aug 2014	14	10	15
Sep 2014	15	11	13
Oct 2014	46	12	25
Nov 2014	40	17	14
Dec 2014	36	5	10
Total 2014	360	198	241
Jan 2015	30	13	7
Feb 2015	23	24	11
Mar 2015	35	11	8
Apr 2015	40	13	9
May 2015	71	16	9
Jun 2015	59	27	8
Jul 2015	41	30	13
Aug 2015	18	5	7
Sep 2015	46	10	5
Oct 2015	29	17	9
Nov 2015	45	26	13
Dec 2015	30	12	4
Total 2015	467	204	103
Jan 2016	66	19	21
Feb 2016	57	14	18
Mar 2016	46	18	19
Apr 2016	19	10	2
May 2016	38	18	2
Jun 2016	24	15	10
Jul 2016	12	8	4
Aug 2016	17	23	12
Sep 2016	27	12	12
Oct 2016	19	20	9
Nov 2016	20	23	10
Dec 2016	9	14	7
Total 2016	354	194	126
Jan 2017	15	12	8
Feb 2017	12	24	7
Mar 2017	8	53	11
Apr 2017	17	21	13
May 2017	14	77	9
Jun 2017	12	14	9
Jul 2017	9	10	5
Aug 2017	3	12	8
Sep 2017	9	15	3
Oct 2017	13	12	5
Nov 2017	11	20	18
Dec 2017	6	19	6
Total 2017	129	289	102
Jan 2018	5	16	3
Feb 2018	11	24	5
Mar 2018	11	13	5
Apr 2018	6	20	10
May 2018	12	34	11
Jun 2018	10	27	9
Jul 2018	4	20	5
Aug 2018	7	21	9
Sep 2018	2	37	8
Oct 2018	19	65	18
Nov 2018	5	53	12
Dec 2018	6	26	5
Total 2018	98	356	100
Jan 2019	11	23	13
Feb 2019	5	24	10
Mar 2019	11	21	22
Apr 2019	6	26	11
May 2019	8	16	16
Jun 2019	7	20	17
Jul 2019	2	14	8
Aug 2019	4	90	17
Sep 2019	7	75	9
Oct 2019	7	109	12
Nov 2019	24	18	16
Dec 2019	8	18	9
Total 2019	100	454	160
Jan 2020	5	20	11
Feb 2020	5	27	11
Mar 2020	9	16	13
Apr 2020	8	9	5
May 2020	6	14	10
Jun 2020	12	15	15
Jul 2020	3	7	8
Aug 2020	9	18	8
Sep 2020	5	21	3
Oct 2020	13	30	22
Nov 2020	8	30	22
Dec 2020	7	33	8
Total 2020	90	240	136
Jan 2021	11	39	21
Feb 2021	7	34	10
Mar 2021	11	40	21
Apr 2021	12	26	20
Total 2021	41	139	72
Total	5130	6318	4240