Long-Term Potentiation Induced by θ Frequency Stimulation Is Regulated by a Protein Phosphatase-1-Operated Gate

George P. Brown; Robert D. Blitzer; John H. Connor; Tony Wong; Shirish Shenolikar; Ravi Iyengar; Emmanuel M. Landau

doi:10.1523/JNEUROSCI.20-21-07880.2000

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.20-21-07880.2000

PubMed

11050107

Published By

Society for Neuroscience

History

Received June 26, 2000
Revision received August 10, 2000
Accepted August 14, 2000
First published November 1, 2000.

Version of record published November 1, 2000.

Author Information

George P. Brown1,
Robert D. Blitzer2,3,
John H. Connor4,
Tony Wong2,
Shirish Shenolikar4,
Ravi Iyengar1, and
Emmanuel M. Landau1,2,3

¹Departments of Pharmacology and
²Psychiatry, Mount Sinai School of Medicine, New York, New York 10029,
³Psychiatry Service, Bronx Veterans Administration Medical Center, Bronx, New York 10468, and
⁴Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27712

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Author contributions

Disclosures

Received June 26, 2000.
Revision received August 10, 2000.
Accepted August 14, 2000.

This research was supported by National Institutes of Health Grants NS33646 to E.M.L., GM5408 to R.I., and DK5204 to S.S. and a Veterans Administration Merit Award to E.M.L. G.P.B. is a recipient of individual National Research Service Award GM 18887. We thank H. Schulman and A. P. Braun for samples of autocamtide-3 and control peptide.
Correspondence should be addressed to Dr. Robert D. Blitzer, Box 1215, Department of Pharmacology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029. E-mail: rb2{at}doc.mssm.edu.

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	Abstract	Full	Pdf
Oct 2000	234	229	240
Nov 2000	84	165	111
Dec 2000	11	39	43
Total 2000	329	433	394
Jan 2001	8	40	20
Feb 2001	7	33	16
Mar 2001	6	33	16
Apr 2001	6	42	25
May 2001	8	42	24
Jun 2001	3	36	18
Jul 2001	2	27	15
Aug 2001	2	36	16
Sep 2001	3	36	18
Oct 2001	5	23	17
Nov 2001	7	32	20
Dec 2001	4	29	11
Total 2001	61	409	216
Jan 2002	2	39	22
Feb 2002	3	19	14
Mar 2002	4	14	8
Apr 2002	1	11	17
May 2002	4	14	11
Jun 2002	1	16	19
Jul 2002	1	14	21
Aug 2002	4	21	20
Sep 2002	2	16	22
Oct 2002	4	26	23
Nov 2002	1	15	17
Dec 2002	0	17	17
Total 2002	27	222	211
Jan 2003	2	13	12
Feb 2003	1	27	18
Mar 2003	2	22	17
Apr 2003	2	12	7
May 2003	2	23	17
Jun 2003	3	7	3
Jul 2003	7	17	15
Aug 2003	6	21	10
Sep 2003	7	28	18
Oct 2003	13	28	18
Nov 2003	20	33	9
Dec 2003	9	29	8
Total 2003	74	260	152
Jan 2004	21	25	14
Feb 2004	9	18	8
Mar 2004	16	30	10
Apr 2004	17	18	12
May 2004	26	26	14
Jun 2004	14	22	9
Jul 2004	17	18	9
Aug 2004	44	54	18
Sep 2004	32	42	17
Oct 2004	12	26	6
Nov 2004	10	32	10
Dec 2004	14	30	12
Total 2004	232	341	139
Jan 2005	14	49	10
Feb 2005	12	26	10
Mar 2005	16	30	9
Apr 2005	9	19	8
May 2005	6	23	9
Jun 2005	13	24	6
Jul 2005	11	16	6
Aug 2005	9	22	8
Sep 2005	8	22	8
Oct 2005	9	17	4
Nov 2005	9	26	2
Dec 2005	8	25	8
Total 2005	124	299	88
Jan 2006	5	13	8
Feb 2006	6	20	12
Mar 2006	4	14	5
Apr 2006	6	17	8
May 2006	5	10	10
Jun 2006	5	7	4
Jul 2006	3	9	6
Aug 2006	2	12	7
Sep 2006	3	19	9
Oct 2006	2	15	7
Nov 2006	10	9	3
Dec 2006	5	16	8
Total 2006	56	161	87
Jan 2007	3	11	10
Feb 2007	2	15	5
Mar 2007	7	18	8
Apr 2007	5	16	9
May 2007	6	15	9
Jun 2007	2	17	10
Jul 2007	2	18	4
Aug 2007	1	17	12
Sep 2007	3	16	8
Oct 2007	1	19	9
Nov 2007	4	16	13
Dec 2007	3	12	5
Total 2007	39	190	102
Jan 2008	0	12	8
Feb 2008	3	12	5
Mar 2008	6	13	5
Apr 2008	15	12	11
May 2008	11	4	7
Jun 2008	9	10	2
Jul 2008	4	17	13
Aug 2008	17	17	5
Sep 2008	14	18	11
Oct 2008	21	12	8
Nov 2008	11	10	3
Dec 2008	8	8	4
Total 2008	119	145	82
Jan 2009	4	5	5
Feb 2009	36	10	7
Mar 2009	52	14	5
Apr 2009	6	8	5
May 2009	7	11	9
Jun 2009	3	6	3
Jul 2009	5	6	3
Aug 2009	7	8	4
Sep 2009	0	4	8
Oct 2009	5	11	10
Nov 2009	4	5	1
Dec 2009	4	10	4
Total 2009	133	98	64
Jan 2010	5	7	6
Feb 2010	3	6	2
Mar 2010	3	6	4
Apr 2010	2	8	1
May 2010	2	6	4
Jun 2010	2	4	4
Jul 2010	23	30	7
Aug 2010	3	7	3
Sep 2010	2	7	5
Oct 2010	5	14	3
Nov 2010	3	12	11
Dec 2010	3	11	12
Total 2010	56	118	62
Jan 2011	6	22	16
Feb 2011	1	22	10
Mar 2011	22	37	13
Apr 2011	4	23	7
May 2011	8	13	7
Jun 2011	11	17	7
Jul 2011	9	16	11
Aug 2011	6	16	5
Sep 2011	6	10	5
Oct 2011	17	9	8
Nov 2011	2	15	15
Dec 2011	9	6	8
Total 2011	101	206	112
Jan 2012	6	12	9
Feb 2012	14	6	11
Mar 2012	22	6	11
Apr 2012	6	9	13
May 2012	7	3	7
Jun 2012	8	3	3
Jul 2012	10	7	11
Aug 2012	13	5	11
Sep 2012	2	2	6
Oct 2012	4	2	5
Nov 2012	20	7	7
Dec 2012	27	7	10
Total 2012	139	69	104
Jan 2013	10	10	8
Feb 2013	15	8	8
Mar 2013	12	2	16
Apr 2013	17	6	11
May 2013	11	4	17
Jun 2013	3	4	12
Jul 2013	1	4	14
Aug 2013	5	3	8
Sep 2013	3	6	12
Oct 2013	10	4	10
Nov 2013	10	3	13
Dec 2013	2	2	13
Total 2013	99	56	142
Jan 2014	17	1	7
Feb 2014	1	1	10
Mar 2014	4	2	12
Apr 2014	7	7	11
May 2014	8	4	17
Jun 2014	12	8	7
Jul 2014	20	9	17
Aug 2014	4	9	15
Sep 2014	6	2	9
Oct 2014	7	7	9
Nov 2014	5	9	21
Dec 2014	4	4	34
Total 2014	95	63	169
Jan 2015	4	3	8
Feb 2015	5	3	6
Mar 2015	3	9	15
Apr 2015	4	5	16
May 2015	2	5	12
Jun 2015	3	2	10
Jul 2015	5	10	27
Aug 2015	5	8	28
Sep 2015	8	11	12
Oct 2015	9	3	17
Nov 2015	6	12	19
Dec 2015	4	12	19
Total 2015	58	83	189
Jan 2016	15	3	15
Feb 2016	17	13	16
Mar 2016	7	5	16
Apr 2016	4	5	21
May 2016	12	6	19
Jun 2016	3	11	24
Jul 2016	7	10	19
Aug 2016	6	6	19
Sep 2016	6	8	19
Oct 2016	3	8	23
Nov 2016	3	6	34
Dec 2016	5	9	35
Total 2016	88	90	260
Jan 2017	3	15	23
Feb 2017	4	26	18
Mar 2017	2	22	24
Apr 2017	4	10	46
May 2017	7	38	30
Jun 2017	4	15	33
Jul 2017	1	11	18
Aug 2017	0	11	8
Sep 2017	1	3	2
Oct 2017	3	31	8
Nov 2017	2	22	7
Dec 2017	3	10	8
Total 2017	34	214	225
Jan 2018	2	17	5
Feb 2018	2	18	6
Mar 2018	2	9	5
Apr 2018	2	25	5
May 2018	2	22	8
Jun 2018	2	29	4
Jul 2018	3	21	3
Aug 2018	2	9	0
Sep 2018	5	25	4
Oct 2018	8	27	4
Nov 2018	2	10	7
Dec 2018	0	12	3
Total 2018	32	224	54
Jan 2019	1	11	13
Feb 2019	0	18	5
Mar 2019	0	11	6
Apr 2019	2	18	6
May 2019	2	19	14
Jun 2019	4	17	8
Jul 2019	2	13	2
Aug 2019	3	10	6
Sep 2019	0	29	0
Oct 2019	3	52	3
Nov 2019	3	25	12
Dec 2019	2	21	10
Total 2019	22	244	85
Jan 2020	5	16	5
Feb 2020	1	15	4
Mar 2020	2	10	3
Apr 2020	0	36	2
May 2020	1	63	5
Jun 2020	4	16	6
Jul 2020	0	12	1
Aug 2020	0	14	3
Sep 2020	1	17	2
Oct 2020	1	33	5
Nov 2020	4	23	7
Dec 2020	6	25	3
Total 2020	25	280	46
Jan 2021	0	23	4
Feb 2021	0	17	1
Total 2021	0	40	5
Total	1943	4245	2988